Association of normal body mass index and weight loss with long-term major cardiovascular events after PCI for myocardial infarction
Open accessAbstract
Objectives: To investigate whether normal body mass index (BMI) shortly after percutaneous coronary intervention (PCI) for myocardial infarction is associated with increased risk of long-term major cardiovascular events (MACE), and to explore potential clinical determinants of long-term weight loss (WL) after PCI. Methods: Single-center cohort study with 5-year follow-up of patients treated with PCI for myocardial infarction between 2016 and 2018. Categorical WL was defined as > 0 kg body weight reduction from baseline to end of follow-up. Results: Of 236 patients (24% women), mean age was 64.9 ± 10.2 years and mean BMI within 4 days after PCI was 27.1 ± 4.3 kg/m2. Seventy-five patients (32%) had at least one MACE, equally distributed between those with normal weight (31%), overweight (32%), and obesity (31%). Patients with overweight or obesity had a lower crude mortality rate than their normal weight counterparts (7.4% vs 16.4%, p = 0.049), but the relative hazard of death did not differ from those with normal weight, HR 0.50, 95% CI 0.22-1.15. Patients with either a long-term WL (n = 112) or no WL (n = 95) had a comparable incidence of non-fatal MACE (27% vs 22%, p = 0.518). The proportion of patients reporting unintentional weight loss was significantly higher in the normal weight group (82%) compared with those with overweight (41%) or obesity (28%), p < 0.001. Conclusion: Our results did not confirm any association between normal BMI after PCI and long-term MACE. However, patients with normal BMI at baseline had a higher incidence of unintentional WL than those with elevated BMI. Trial registration: Current research information system in Norway (CRISTIN): ID 542528
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In the placebo group, substantial weight loss may have been unintentional in some patients and driven by comorbid conditions that also influenced MACE risk.
“suggesting that substantial weight loss may have been unintentional in some of those patients and driven by comorbid conditions that also influenced the risk of MACE.20”
From Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial (2025) · cites this paper as [20]
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- Authors
- Otterstad, J. E., Munkhaugen, J., Ruddox, V., Edvardsen, T., & Hjelmesæth, J.
- Affiliations
- Sykehuset i Vestfold (NO)
- University of Oslo (NO)
- Oslo University Hospital (NO)
- Department of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tønsberg, Norway
- Corresponding author
- Otterstad, Jan Erik
- Venue
- Scandinavian Cardiovascular Journal
- Publisher
- Informa UK Limited
- Published
- 2024-08-06
- Volume
- 58
- Issue
- 1
- Pages
- 2386984-2386984
- ISSN
- 1401-7431 (ISSN-L)
- 1651-2006
- OpenAlex
- W4401360499
- Cited by
- 4
- References
- 17
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Scandinavian Cardiovascular Journal (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- body mass index, weight loss, myocardial infarction, percutaneous coronary intervention, major adverse cardiovascular events, unintentional weight loss, obesity, overweight, mortality, long-term follow-up
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Myocardial Infarction, Obesity, Retrospective Studies, Risk Factors, Time Factors, Weight Loss, Body Mass Index, Treatment Outcome, Risk Assessment, Percutaneous Coronary Intervention
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