Functional biomimetic nanoparticles for drug delivery and theranostic applications in cancer treatment
Open accessAbstract
Nanotechnology has been extensively utilized in the design and development of powerful strategies for drug delivery and cancer theranostic. Nanoplatforms as a drug delivery system have many advantages such as in vivo imaging, combined drug delivery, extended circulation time, and systemic controlled release. The functional biomimetic drug delivery could be realized by incorporating stimuli-responsive (pH, temperature, redox potential, etc.) properties into the nanocarrier system, allowing them to bypass biological barriers and arrive at the targeted area. In this review, we discuss the role of internal stimuli-responsive nanocarrier system for imaging and drug delivery in cancer therapy. The development of internal stimuli-responsive nanoparticles is highlighted for precision drug delivery applications, with a particular focus on in vivo imaging, drug release performance, and therapeutic benefits.
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Many redox-responsive nanoparticles have been investigated for the delivery of chemotherapeutic drugs to treat cancer, including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.
“For the delivery of chemotherapeutic drugs to treat cancer, many redox-responsive nanoparticles have been investigated recently,166 including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.167,168”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [167]
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References 145 · Cited by 71
Research works printed but not linked: 2
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- Authors
- Li, L., Wang, J., Kong, H., Zeng, Y., & Liu, G.
- Affiliations
- Xiamen University (CN)
- Xiamen Medical College (CN)
- Corresponding author
- Liu, Gang
- Venue
- Science and Technology of Advanced Materials
- Publisher
- Informa UK Limited
- Published
- 2018-10-26
- Volume
- 19
- Issue
- 1
- Pages
- 771-790
- ISSN
- 1468-6996 (ISSN-L)
- 1878-5514
- PMC
- PMC6383616
- OpenAlex
- W2898586647
- Cited by
- 71
- References
- 145
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 13 · 2019: 11 · 2018: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-02-18)
- Open access
- gold
- doi.org
- Locations
- Science and Technology of Advanced Materials (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81801817, 81422023, 81371596, 51273165, U1705281, and U1505221)
- Fundamental Research Funds for the Central Universities, China (20720150206 and 20720150141)
- Major State Basic Research Development Program of China (2017YFA0205201, 2014CB744503, and 2013CB733802)
- Program for New Century Excellent Talents in University (NCET-13-0502)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- biomimetic nanoparticles, drug delivery, cancer theranostics, stimuli-responsive nanocarriers, internal stimuli, in vivo imaging, controlled drug release, targeted drug delivery, cancer therapy
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