The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Romosozumab for the treatment of osteoporosis
Abstract
Introduction Sclerostin, a glycoprotein produced primarily by osteocytes, blocks the canonical Wnt signaling bone formation pathway. Romosozumab is a humanized monoclonal antibody to sclerostin that binds to sclerostin, permitting the engagement of Wnt ligands with their co-receptors, resulting in an increase in bone formation and bone mineral density (BMD). Clinical studies with romosozumab have shown dramatic improvements in BMD at the spine and hip. Romosozumab is associated with improvement in bone strength through mechanisms that include increases in bone formation and, different from classical osteoanabolic agents, suppression of bone resorption. Areas covered: Herein, the authors highlight the available data on romosozumab for the treatment of osteoporosis. This includes the latest data on the efficacy, pharmacokinetics and pharmacodynamics as well as safety and tolerability data. Expert opinion: Monthly subcutaneous dosing of romosozumab reduces the risk of vertebral and clinical fractures in women with postmenopausal osteoporosis, with a favorable balance of benefits and risks. Romosozumab is a promising emerging anabolic agent with a novel mechanism of action that may expand the options for treating osteoporotic patients at high risk of fracture.
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“monthly subcutaneous injections of romosozumab are effective in increasing bone formation and density and decreasing bone resorption”
From Osteoclasts and Microgravity (2020) · cites this paper as [73]
Citations
Cites
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Items 101–101 of 101
Metadata
- Authors
- Bandeira, L., Lewiecki, E. M., & Bilezikian, J. P.
- Affiliations
- Columbia University Irving Medical Center (US)
- New Mexico Clinical Research & Osteoporosis Center (US)
- Corresponding author
- Lewiecki, E. Michael
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa UK Limited
- Published
- 2017-01-19
- Volume
- 17
- Issue
- 2
- Pages
- 255-263
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- OpenAlex
- W2571025776
- Cited by
- 101
- References
- 75
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 15 · 2020: 21 · 2019: 9 · 2018: 3 · 2017: 3
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Biological Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- romosozumab, sclerostin, osteoporosis, postmenopausal osteoporosis, Wnt signaling, bone formation, bone mineral density, bone resorption, fracture risk, anabolic therapy, monoclonal antibodies, pharmacokinetics, pharmacodynamics, safety and tolerability
- MeSH terms
- Animals, Antibodies, Monoclonal, Clinical Trials as Topic, Female, Humans, Osteogenesis, Osteoporosis, Bone Density, Osteoporosis, Postmenopausal, Treatment Outcome, Bone Density Conservation Agents, Antibodies, Monoclonal, Humanized
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