Cited by 101Bone health and osteoporosis researchBone Metabolism and DiseasesBone health and treatments

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Romosozumab for the treatment of osteoporosis

Bandeira, Leonardo, Lewiecki, E. Michael, Bilezikian, John P.·2017·Expert Opinion on Biological Therapy

DOI 10.1080/14712598.2017.1280455

Open this paper in CoChat — free account

Abstract

Introduction Sclerostin, a glycoprotein produced primarily by osteocytes, blocks the canonical Wnt signaling bone formation pathway. Romosozumab is a humanized monoclonal antibody to sclerostin that binds to sclerostin, permitting the engagement of Wnt ligands with their co-receptors, resulting in an increase in bone formation and bone mineral density (BMD). Clinical studies with romosozumab have shown dramatic improvements in BMD at the spine and hip. Romosozumab is associated with improvement in bone strength through mechanisms that include increases in bone formation and, different from classical osteoanabolic agents, suppression of bone resorption. Areas covered: Herein, the authors highlight the available data on romosozumab for the treatment of osteoporosis. This includes the latest data on the efficacy, pharmacokinetics and pharmacodynamics as well as safety and tolerability data. Expert opinion: Monthly subcutaneous dosing of romosozumab reduces the risk of vertebral and clinical fractures in women with postmenopausal osteoporosis, with a favorable balance of benefits and risks. Romosozumab is a promising emerging anabolic agent with a novel mechanism of action that may expand the options for treating osteoporotic patients at high risk of fracture.

Integrity signals

Registry

Crossref · 10.1080/14712598.2017.1280455

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Osteoporosis Prevention, Diagnosis, and Therapy
NIH Consensus Development Panel on Osteoporosis Prevention, D. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.6.785 · Cited by 5,529
Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis
Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J.-Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441904 · Cited by 4,602
Clinician’s Guide to Prevention and Treatment of Osteoporosis
Cosman, F., de Beur, S. J., LeBoff, M. S., Lewiecki, E. M., Tanner, B., Randall, S., & Lindsay, R. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2794-2 · Cited by 4,149
Self-citation
The diagnosis of osteoporosis
Professor Kanis, J. A., Melton, L. J., Christiansen, C., Johnston, C. C., & Khaltaev, N. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090802 · Cited by 3,849
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Kanis, J. A., McCloskey, E. V., Johansson, H., Cooper, C. C., Rizzoli, R., & Reginster, J. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2074-y · Cited by 2,993
Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis
Black, D. M., Delmas, P. D., Eastell, R., Reid, I. R., Boonen, S., Cauley, J. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067312 · Cited by 2,986
Effects of Risedronate Treatment on Vertebral and Nonvertebral Fractures in Women With Postmenopausal Osteoporosis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Harris, S. T. (1999) · JAMA · doi:10.1001/jama.282.14.1344 · Cited by 2,475
Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American Society for Bone and Mineral Research
Shane, E., Burr, D., Abrahamsen, B., Adler, R. A., Brown, T. D., Cheung, A. M., Cosman, F., Curtis, J. R., Dell, R., Dempster, D. W., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1998 · Cited by 2,147
WNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093

Show all 75 references

Research works printed but not linked: 3

Holanda NCP, 2015, Endocrinologia e Diabetes, 457
Truswell AS, 1958, J Bone Joint Surg Br, 40, 209
Genant HK, 2016, J Bone Miner Res, 1

Sorted by citations

Osteoporosis in Older Adults
Johnston, C. B., & Dagar, M. (2020) · Medical Clinics of North America · doi:10.1016/j.mcna.2020.06.004 · Cited by 666
Osteoporosis pathogenesis and treatment: existing and emerging avenues
Liang, B., Burley, G., Lin, S., & Shi, Y. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00371-3 · Cited by 250
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development
Li, H., Xiao, Z., Quarles, L. D., & Li, W. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867327666200330142432 · Cited by 226
Osteoporosis in patients with chronic kidney diseases: A systemic review
Hsu, C.-Y., Chen, L.-R., & Chen, K.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186846 · Cited by 162
Insights and implications of sexual dimorphism in osteoporosis
Zhang, Y., Xie, N., Sun, X., Nice, E. C., Liou, Y., Huang, C., Zhu, H., & Shen, Z. (2024) · Bone Research · doi:10.1038/s41413-023-00306-4 · Cited by 164
Regulation of bone homeostasis: signaling pathways and therapeutic targets
Wu, Z., Li, W., Jiang, K., Lin, Z., Qian, C., Wu, M., Xia, Y., Li, N., Zhang, H., Xiao, H.-X., et al. (2024) · MedComm · doi:10.1002/mco2.657 · Cited by 129
Ovariectomy Activates Chronic Low-Grade Inflammation Mediated by Memory T Cells, Which Promotes Osteoporosis in Mice
Cline-Smith, A., Axelbaum, A., Shashkova, E., Chakraborty, M., Sanford, J., Panesar, P., Peterson, M., Cox, L., Baldan, A., Veis, D., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3966 · Cited by 108
The prevention of osteoporosis and sarcopenia in older adults
Coll, P. P., Phu, S., Hajjar, S. H., Kirk, B., Duque, G., & Taxel, P. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17043 · Cited by 101
Osteoporosis, bone mineral density and CKD–MBD: treatment considerations
Bover, J., Bailone, L., López‐Báez, V., Benito, S., Ciceri, P., Galassi, A., & Cozzolino, M. G. (2017) · Journal of Nephrology · doi:10.1007/s40620-017-0404-z · Cited by 87
Deciphering the Relevance of Bone ECM Signaling
Alcorta-Sevillano, N., Macías, I., Infante, A., & Rodrı́guez, C. I. (2020) · Cells · doi:10.3390/cells9122630 · Cited by 89
Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial
Edwards, W. B., Simonian, N., Haider, I. T., Anschel, A. S., Chen, D., Gordon, K. E., Gregory, E. K., Kim, K. H., Parachuri, R., Troy, K. L., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3525 · Cited by 72
Anabolic therapy for osteoporosis: update on efficacy and safety
Bandeira, L., & Lewiecki, E. M. (2022) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000566 · Cited by 66
Self-citation
Advances in the occurrence and biotherapy of osteoporosis
Zi, Z., Liu, W. X., Cao, L., Liu, Y., He, T., Peng, S., & Shuai, C. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200005 · Cited by 59
Dietary phlorizin enhances osteoblastogenic bone formation through enhancing β-catenin activity via GSK-3β inhibition in a model of senile osteoporosis
Antika, L. D., Lee, E., Kim, Y., Kang, M., Park, S., Kim, D. Y., Oh, H., Choi, Y. J., & Kang, Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.07.014 · Cited by 57
Osteoclasts and Microgravity
Smith, J. K. (2020) · Life · doi:10.3390/life10090207 · Cited by 52
Early clinical effects, safety, and predictors of the effects of romosozumab treatment in osteoporosis patients: one-year study
Tominaga, A., Wada, K., Okazaki, K., Nishi, H., Terayama, Y., & Kato, Y. (2021) · Osteoporosis International · doi:10.1007/s00198-021-05925-3 · Cited by 50
Romosozumab: A Novel Agent in the Treatment for Postmenopausal Osteoporosis
Miller, S. A., St. Onge, E. L., & Whalen, K. L. (2021) · Journal of Pharmacy Technology · doi:10.1177/8755122520967632 · Cited by 46
Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis
Gambari, L., Grassi, F., Roseti, L., Grigolo, B., & Desando, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176001 · Cited by 46
Comprehensive circular RNA profiling reveals circ_0002060 as a potential diagnostic biomarkers for osteoporosis
Huang, Y.-P., Xie, J., & Li, E. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28838 · Cited by 44
Targeting SOST using a small-molecule compound retards breast cancer bone metastasis
Sun, L., Zhang, Y., Chen, G., Ji, Y., Ma, Q., Qiao, X., Wu, S., Zhou, L. M., Bu, J., Zhu, X., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01697-4 · Cited by 40
Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
Gould, N. R., Williams, K. M., Joca, H. C., Torre, O. M., Lyons, J. S., Leser, J. M., Srikanth, M. P., Hughes, M., Khairallah, R. J., Feldman, R. A., et al. (2021) · eLife · doi:10.7554/elife.64393 · Cited by 40
Secreted Frizzled‐related proteins (sFRPs) in osteo‐articular diseases: much more than simple antagonists of Wnt signaling?
Claudel, M., Jouzeau, J., & Cailotto, F. (2019) · FEBS Journal · doi:10.1111/febs.15119 · Cited by 39
Aberrant BMP2 Signaling in Patients Diagnosed with Osteoporosis
Durbano, H. W., Halloran, D. R., Nguyen, J., Stone, V., McTague, S., Eskander, M. S., & Nohe, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186909 · Cited by 38
Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis
Wang, Y., Xie, J. W., Ai, Z., & Su, J. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s213724 · Cited by 36
CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression
Li, M.-Y., Li, C., Zheng, H., Zhou, Z., Yang, W., Gong, Y., Wu, X., & Li, L.-Y. (2022) · Bioengineered · doi:10.1080/21655979.2021.2022074 · Cited by 27
Evaluation and Management of Osteoporosis and Sarcopenia in Patients with Distal Radius Fractures
Shah, G. M., Gong, H. S., Chae, Y. J., Kim, Y. S., Kim, J., & Baek, G. H. (2020) · Clinics in Orthopedic Surgery · doi:10.4055/cios.2020.12.1.9 · Cited by 35
Orthodontic retention: what's on the horizon?
Littlewood, S., Dalci, O., Dolce, C., Holliday, L. S., & Naraghi, S. (2021) · BDJ · doi:10.1038/s41415-021-2937-8 · Cited by 36
Sphingosine‐1‐phosphate (S1P) receptors: Promising drug targets for treating bone‐related diseases
Zhang, L., Dong, Y., Wang, Y., Hu, W., Dong, S., & Chen, Y. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15155 · Cited by 34
Effect of the duration of previous osteoporosis treatment on the effect of romosozumab treatment
Tominaga, A., Wada, K., Okazaki, K., Nishi, H., Terayama, Y., Kodama, Y., & Kato, Y. (2022) · Osteoporosis International · doi:10.1007/s00198-021-06261-2 · Cited by 32
Osteoporosis in Inflammatory Arthritides: New Perspective on Pathogenesis and Treatment
Rotta, D., Fassio, A., Rossini, M., Giollo, A., Viapiana, O., Orsolini, G., Bertoldo, E., Gatti, D., & Adami, G. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.613720 · Cited by 29
The pathophysiology of immunoporosis: innovative therapeutic targets
Ferbebouh, M., Vallières, F., Benderdour, M., & Fernandes, J. (2021) · Inflammation Research · doi:10.1007/s00011-021-01484-9 · Cited by 31
Circ‐SLC8A1 regulates osteoporosis through blocking the inhibitory effect of miR‐516b‐5p on AKAP2 expression
Lin, C., Zhong, W., Yan, W., Yang, J., Zheng, W., & Wu, Q. (2020) · Journal of Gene Medicine · doi:10.1002/jgm.3263 · Cited by 22
Efficacy of romosozumab for osteoporosis in a patient with osteogenesis imperfecta: A case report
Uehara, M., Nakamura, Y., Nakano, M., Miyazaki, A., Suzuki, T., & Takahashi, J. (2021) · Modern Rheumatology Case Reports · doi:10.1093/mrcr/rxab018 · Cited by 25
Medical optimization of osteoporosis for adult spinal deformity surgery: a state-of-the-art evidence-based review of current pharmacotherapy
Zhang, A. S., Khatri, S., Balmaceno-Criss, M., Alsoof, D., & Daniels, A. H. (2022) · Spine Deformity · doi:10.1007/s43390-022-00621-6 · Cited by 25
Increased Serum Sclerostin Levels in Patients With Active Acromegaly
Pekkolay, Z., Kılınç, F., Gözel, N., Etem, E. Ö., & Tuzcu, A. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz254 · Cited by 23
Early clinical effects, safety, and appropriate selection of bone markers in romosozumab treatment for osteoporosis patients: a 6-month study
Tominaga, A., Wada, K., Kato, Y., Nishi, H., Terayama, Y., & Okazaki, K. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05639-y · Cited by 22
Cyclooxygenase-2/sclerostin mediates TGF-β1-induced calcification in vascular smooth muscle cells and rats undergoing renal failure
He, F., Li, L., Li, P., Deng, Y., Yang, Y., Deng, Y., Luo, H., Yao, X., Su, Y., Gan, H., et al. (2020) · Aging · doi:10.18632/aging.103827 · Cited by 20
Open-label clinical trial of alendronate after teriparatide therapy in people with spinal cord injury and low bone mineral density
Haider, I. T., Simonian, N., Saini, A. S., Leung, F. M., Edwards, W. B., & Schnitzer, T. J. (2019) · Spinal Cord · doi:10.1038/s41393-019-0303-3 · Cited by 22
Oral Administration of Isovitexin, a Naturally Occurring Apigenin Derivative Showed Osteoanabolic Effect in Ovariectomized Mice: A Comparative Study with Teriparatide
Pal, S., Sharma, S., Porwal, K., Riyazuddin, M., Kulkarni, C., Chattopadhyay, S., Sanyal, S., Gayen, J. R., & Chattopadhyay, N. (2022) · Calcified Tissue International · doi:10.1007/s00223-022-00979-9 · Cited by 19
Examining the role of cannabinoids on osteoporosis: a review
Clouse, G., Penman, S. L., Hadjiargyrou, M., Komatsu, D. E., & Thanos, P. K. (2022) · Archives of Osteoporosis · doi:10.1007/s11657-022-01190-x · Cited by 19
Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality
Shao, Y., Zielinski, E., Childress, P., Adaway, M., Misra, J., Klunk, A. J., Burr, D. B., Wek, R. C., Mosley, A. L., Liu, Y., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00343.2018 · Cited by 20
Sclerostin: clinical insights in muscle–bone crosstalk
Moretti, A., & Iolascon, G. (2023) · Journal of International Medical Research · doi:10.1177/03000605231193293 · Cited by 18
Leonurine hydrochloride promotes osteogenic differentiation and increases osteoblastic bone formation in ovariectomized mice by Wnt/β-catenin pathway
Yang, L., Liu, S., Mu, S., Man, X., Ba, G., Guo, R., Li, Y., Zhou, L., Yang, L., & Fu, Q. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.008 · Cited by 17
BMP delivery systems for bone regeneration: Healthy vs osteoporotic population. Review
Segredo-Morales, E., García‐García, P., Évora, C., & Delgado, A. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.05.014 · Cited by 17
Monitoring and maintaining bone health in patients with Turner syndrome
Chiarito, M., Brunetti, G., D’Amato, G., & Faienza, M. F. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1834846 · Cited by 16
Carfilzomib alleviated osteoporosis by targeting PSME1/2 to activate Wnt/β-catenin signaling
Zhang, F., Attarilar, S., Xie, K., Han, C., Liang, Q., Huang, K., Lan, C., Wang, C., Yang, C., Wang, L., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111520 · Cited by 15
Prevention of Osteoporotic Fractures in Residential Aged Care: Updated Consensus Recommendations
Duque, G., Iuliano, S., Close, J., Fatima, M., Ganda, K., Bird, S., Kirk, B., Levidiotis, M. L., Said, C. M., Παπαϊωάννου, Α., et al. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.12.041 · Cited by 15
Clinical Characteristics and Controllable Risk Factors of Osteoporosis in Elderly Men with Diabetes Mellitus
Li, C., Wang, S., Du, M.-R., Wei, Y., & Jiang, S. (2021) · Orthopaedic Surgery · doi:10.1111/os.12957 · Cited by 13
Does Aging Activate T-cells to Reduce Bone Mass and Quality?
Aurora, R., & Novack, D. V. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00745-8 · Cited by 13
Microgravity, Bone Homeostasis, and Insulin-Like Growth Factor-1
Smith, J. K. (2020) · Applied Sciences · doi:10.3390/app10134433 · Cited by 10
The Dietary and Non-Dietary Management of Osteoporosis in Adult-Onset Celiac Disease: Current Status and Practical Guidance
Al-Toma, A. A., Herman, A., Lems, W. F., & Mulder, C. J. J. (2022) · Nutrients · doi:10.3390/nu14214554 · Cited by 13
An update on the pharmacotherapy of osteoporosis
Shashidhara, A., Tahir, S. H., Syed, Z. A., Lee, J., & Tahir, H. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2489122 · Cited by 11
The miR-187 induced bone reconstruction and healing in a mouse model of osteoporosis, and accelerated osteoblastic differentiation of human multipotent stromal cells by targeting BARX2
Zhang, J., Zhang, T., Tang, B., Li, J., & Zha, Z. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153340 · Cited by 10
Novel transplant of combined platelet-rich fibrin Releasate and bone marrow stem cells prevent bone loss in Ovariectomized osteoporotic mice
Wong, C.-C., Liao, J.-H., Sheu, S.-Y., Lin, P.-Y., Chen, C., & Kuo, T. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03549-y · Cited by 10
Controversies in the treatment of postmenopausal osteoporosis: How long to treat with bisphosphonates?
Bandeira, F., Dantas, W., & Bilezikian, J. P. (2020) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000275 · Cited by 9
Self-citation
Osteoporosis Improved by Romosozumab Therapy in a Patient With Type I Osteogenesis Imperfecta
Dattagupta, A., & Petak, S. M. (2023) · AACE Clinical Case Reports · doi:10.1016/j.aace.2023.10.002 · Cited by 9
Osteoporosis in Adult Patients Undergoing Spinal Reconstructive Surgery: Associated Complications and Management
Sardar, Z. M., Coury, J. R., Polly, D. W., Cheung, K., Lewis, S. J., & Deformity, A. S. K. F. (2025) · Global Spine Journal · doi:10.1177/21925682241289899 · Cited by 8
Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design
Yu, S., Huang, W., Zhang, H., Guo, Y., Zhang, B., Zhang, G., & Lei, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116414 · Cited by 9
Role of biophysical stimulation in multimodal management of vertebral compression fractures
Martino, A. C. D., Villari, E., Poluzzi, R., Brunello, M., Rossomando, V., D’Agostino, C., Ruta, F., & Faldini, C. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.11.023 · Cited by 7
Aortic carboxypeptidase‐like protein, a putative myokine, stimulates the differentiation and survival of bone‐forming osteoblasts
Kim, H., Kim, M. J., Moon, S. A., Cho, H. J., Lee, Y., Park, S. J., Kim, Y., Baek, I., Kim, B., Lee, S. H., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202300140r · Cited by 6
Nanomaterials‐Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis
Shi, D., Li, Y., Tian, M., Xue, M., Wang, J., & An, H. (2025) · Advanced Biology · doi:10.1002/adbi.202400721 · Cited by 7
Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other
Nilsson, K. H., Wu, J., Gustafsson, K. L., Shahawy, M. E., Koskela, A., Tuukkanen, J., Tuckermann, J. P., Henning, P., Lerner, U. H., Ohlsson, C., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00383.2021 · Cited by 7
Differential bone remodeling mechanism in hindlimb unloaded rats and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse
Gao, X., Wang, S., Zhang, J., Wang, S., Bai, F., Liang, J., Wu, J., Wang, H., Gao, Y., & Chang, H. (2021) · Journal of Comparative Physiology B · doi:10.1007/s00360-021-01375-9 · Cited by 6
Recent advances in biomimetic nanodelivery systems for the treatment of osteoporosis
Ren, Z., Xiao, W., Yang, T., Han, Y., Bai, L., Feng, L., Guo, J., & Liu, S. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102373 · Cited by 6
Small-Molecule Inhibition of SOST Suppresses Breast Cancer Bone Metastasis
Khalil, Y. H., & Nassar, O. S. (2025) · Archive of International Journal of Cancer and Allied Science · doi:10.51847/xr3tpazzri · Cited by 5
A clinician's guide to the management of geriatric musculoskeletal disease: Part 1 - Osteoporosis
Feehan, J., Tripodi, N., Fleischmann, M., Zanker, J., & Duque, G. (2021) · International journal of osteopathic medicine · doi:10.1016/j.ijosm.2021.12.003 · Cited by 5
Eldecalcitol Induces Minimodeling-Based Bone Formation and Inhibits Sclerostin Synthesis Preferentially in the Epiphyses Rather than the Metaphyses of the Long Bones in Rats
Hasegawa, T., Yamamoto, T., Hongo, H., Yamamoto, T., Haraguchi‐Kitakamae, M., Ishizu, H., Shimizu, T., Saitô, H., Sakai, S., Yogo, K., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084257 · Cited by 5
LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression
Li, L., Zheng, B., Zhang, F., Luo, X. Q., Li, F., Xu, T., Zhao, H. C., Shi, G., Guo, Y., Shi, J., et al. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104505 · Cited by 7
Postmenopausal Osteoporosis
Mesquita, P. N., Maia, J. M. C., Andrade, S. R. D. L., & Bandeira, F. A. F. (2022) · Springer eBooks · doi:10.1007/978-3-030-90684-9_24 · Cited by 5
Clinical challenges and considerations in pharmacotherapy of osteoporosis due to menopause
Palacios, S., Rodríguez, S. P. G., Prieto, M. S., & Fasero, M. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2383639 · Cited by 4
Osteoporosis management in primary care
Jarrell, L. (2023) · The Nurse Practitioner · doi:10.1097/01.npr.0000000000000090 · Cited by 3
Bone turnover markers
Garnero, P., & Cremers, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00078-6 · Cited by 3
The role of anti-osteoporosis drugs in fall risk
Voltan, G., & Veronese, N. (2024) · International Journal of Bone Fragility · doi:10.57582/ijbf.240401.002 · Cited by 3
Deep Learning-Based Self-Efficacy X-Ray Images in the Evaluation of Rheumatoid Arthritis Combined with Osteoporosis Nursing
Geng, Y., Liu, T., Ding, Y., Liu, W., Ye, J., Hu, L., & Ruan, L. (2021) · Scientific Programming · doi:10.1155/2021/9959617 · Cited by 4
The Effects of Oral Administration of Deer Antler Extracts on an Osteoporosis-induced Animal Model: A Systematic Review and Meta-analysis
Lee, J. M., Kim, N. H., & Lee, D. W. (2022) · Journal of Korean Medicine Rehabilitation · doi:10.18325/jkmr.2022.32.2.65 · Cited by 3
Correlation between Body Composition and Bone Mineral Density Differs by Sex and Skeletal Site in Overweight and Obese Chinese Subjects
Chen, X., Guo, Y., Zhou, F., Wang, X., Wang, S., Zhang, C., Li, M., & Wu, Y. (2024) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2024.101526 · Cited by 2
Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw
Park, H.-S., Kim, S., An, S.-Y., Kim, R. H., Choi, J., & Kim, M. Y. (2026) · Oral Diseases · doi:10.1111/odi.70331 · Cited by 2
Indirect Decompression of Osteoporotic Vertebral Compression Fracture Using Intraoperative Motor Evoked Potential Monitoring-Guided Ligamentotaxis
Kweon, S., Kwon, S. M., Kim, C., Lee, C.-Y., Kim, I., & Ko, Y. S. (2023) · Korean Journal of Neurotrauma · doi:10.13004/kjnt.2023.19.e21 · Cited by 2
Does Zoledronic Acid Provide a Good Clinical Outcome in Patients With Chronic Back Pain Associated With Vertebral Osteoporosis?
Umesh, M., Ethiraj, P., Nazar, S. M., Agarawal, S. S., & Shanthappa, A. H. (2023) · Cureus · doi:10.7759/cureus.33328 · Cited by 2
Clinical research–When it matters
Yao, M., Wang, H., & Chen, W. (2022) · Injury · doi:10.1016/j.injury.2022.01.049 · Cited by 1
Progress in Prevention and Treatment of Acute Bone Loss in Orthopedics
Wang, H., Wu, J., Wang, B., Qin, H., Fan, L., Wang, Y.-H., & He, B. (2023) · International Journal of Endocrinology · doi:10.1155/2023/9373043 · Cited by 1
Monoclonal antibodies in patients with osteoporosis and renal insufficiency: An updated systematic review and meta-analysis
Defante, M. L. R., Alzogaray, V., Celso, D. S. G., Torres, L. A. F., Bearse, M., & Lopes, A. C. F. M. D. M. (2024) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2024.05.004 · Cited by 1
Effects of Piper sarmentosum on Bone Health and Fracture Healing: A Scoping Review
Chin, K., Ekeuku, S. O., & Ramli, E. S. M. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666221130152737 · Cited by 1
The Effects of Switch Therapy in Osteoporosis Treatment after Romosozumab after Comparing with Prior Treatment
Horikawa, A., Kasukawa, Y., Hongo, M., Sano, A., & Miyakoshi, N. (2024) · Journal of Osteoporosis · doi:10.1155/2024/2144527 · Cited by 1
Bone-Muscle Crosstalk in Advanced Cancer and Chemotherapy
Waning, D. L. (2022) · Springer eBooks · doi:10.1007/978-3-031-09518-4_9 · Cited by 1
Detection of Branching in Trabecular Bone Using Multiscale COSFIRE Filter for Osteoporosis Identification
Wihandika, R. C., Arifin, A. Z., & Yuniarti, A. (2018) · International Conference on Frontiers of Educational Technologies (ICFET) · doi:10.1145/3233347.3233381
Impacto funcional de polimorfismos del gen de la esclerostina sobre la metilación de ADN y la expresión génica
del Real, Á., Sañudo, C., García‐Ibarbia, C., Santurtún, A., Zarrabeitia, M. T., Pérez‐Núñez, M. I., Laguna-Bercero, E., López-Delgado, L., Fernández, A. F., Fraga, M. F., et al. (2019) · Revista de Osteoporosis y Metabolismo Mineral · doi:10.4321/s1889-836x2019000400004
Is Romosozumab better than Teriparatide for the treatment of osteoporosis? A meta-analysis through a grade analysis of evidencePreprint
Liu, Z.-H., Ma, J., Sun, X., Zhang, S., Kuang, M., & Ma, X. (2019) · Research Square · doi:10.21203/rs.2.13598/v1
Pharmacological therapies for the prevention of fractures in men
Bråten, L. C. H., Johnston, R. V., Suter, C., Saku, S. A., Järvinen, T. L. N., & Buchbinder, R. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014707
Current pharmacotherapy of osteoporosis and its future
Kukowka, A., Pluskota, M., Arciszewski, M., & Sroczyński, T. (2021) · Farmacja Polska · doi:10.32383/farmpol/145401
Condition still critical: compliance and persistence with osteoporosis medications
Gold, D. T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00072-1
Osteoporosis
Cochran, T., & Thacker, H. L. (2022) · Springer eBooks · doi:10.1007/978-3-030-99596-6_10
Antibodies as Therapeutic Agents
Rawat, R. S., & Kumar, S. (2023) · Springer eBooks · doi:10.1007/978-981-19-8249-1_5
Parathyroid Gland and Bone Therapies
Quarde, A. (2023) · doi:10.1002/9781119863564.ch5
Drugs associated with medication-related osteonecrosis of the jaw
Teoh, L., Moses, G., & McCullough, M. J. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009057950.011
Production and Therapeutic Applications of Monoclonal Antibodies in Cancer and Other Diseases
Shahi, A., Patel, G. K., Kumar, S., Singh, M., Varshney, A., & Ghoshal, U. C. (2024) · Wiley eBooks · doi:10.1002/9783527844340.ch26
In silico identification of sclerostin inhibitors
Şımşek, Y., Baran, S. S., Ergünol, E., Uludamar, A., Dinçel, A. S., & Erkoç, Ş. (2025) · Molecular Diversity · doi:10.1007/s11030-025-11298-0
Additional file 1 of Targeting SOST using a small-molecule compound retards breast cancer bone metastasis
Sun, L., Zhang, Y., Chen, G., Ji, Y., Ma, Q., Qiao, X., Wu, S., Zhou, L., Bu, J., Zhu, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26558123
ALKBH5/YTHDF2 Axis Regulates Osteogenic Differentiation Through Mediating the m 6 A Modification of ELK1
Yu, H., Ruan, T., & Peng, Y. (2026) · International Journal of Endocrinology · doi:10.1155/ije/2669506
Unveiling Hope: A Snapshot of CDSCO- Approved Monoclonal Antibodies in India
Bhardwaj, S., Chauhan, R. S., Tomar, A. S., Pachori, S., Mishra, H., Mourya, H., Sahu, T., & Garud, N. (2026) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2026.00208

Authors: Bandeira, L., Lewiecki, E. M., & Bilezikian, J. P.
Affiliations: Columbia University Irving Medical Center (US)
New Mexico Clinical Research & Osteoporosis Center (US)
Corresponding author: Lewiecki, E. Michael
ORCID: Bandeira, Leonardo
Lewiecki, E. Michael
Bilezikian, John P.
Venue: Expert Opinion on Biological Therapy
Publisher: Informa UK Limited
Published: 2017-01-19
Volume: 17
Issue: 2
Pages: 255-263
ISSN: 1471-2598 (ISSN-L)
1744-7682
DOI: 10.1080/14712598.2017.1280455
OpenAlex: W2571025776
Cited by: 101
References: 75
Citations by year: 2026: 3 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 15 · 2020: 21 · 2019: 9 · 2018: 3 · 2017: 3
FWCI: 10.83
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Biological Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords: romosozumab, sclerostin, osteoporosis, postmenopausal osteoporosis, Wnt signaling, bone formation, bone mineral density, bone resorption, fracture risk, anabolic therapy, monoclonal antibodies, pharmacokinetics, pharmacodynamics, safety and tolerability
MeSH terms: Animals, Antibodies, Monoclonal, Clinical Trials as Topic, Female, Humans, Osteogenesis, Osteoporosis, Bone Density, Osteoporosis, Postmenopausal, Treatment Outcome, Bone Density Conservation Agents, Antibodies, Monoclonal, Humanized

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Romosozumab for the treatment of osteoporosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks