Label-Free Plasmonic Biosensors for Point-of-Care Diagnostics: A Review
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Introduction: Optical biosensors, particularly those based on nanoplasmonics technology, have emerged in recent decades as a potential solution for disease diagnostics and therapy follow-up at the point-of-care (POC). These biosensor platforms could overcome some of the challenges faced in conventional diagnosis techniques offering label-free assays with immediate results and employing small and user-friendly devices.Areas covered: In this review, we will provide a critical overview of the recent advances in the development of nanoplasmonic biosensors for the POC diagnostics. We focus on those systems with demonstrated capabilities for integration in portable platforms, highlighting some of the most relevant diagnostics applications targeting proteins, nucleic acids, and cells as disease biomarkers.Expert commentary: Despite the attractive features of label-free nanoplasmonic sensors in terms of miniaturization and analytical robustness, the route toward an effective clinical implementation involves the integration of fully automated microfluidic systems for sample processing and analysis, and the optimization of surface biofunctionalization procedures. Additionally, the development of multiplexed sensors for high-throughput analysis and including specific neoantigens and novel biomarkers in detection panels will provide the means for delivering a powerful analytical technology for an accurate and improved medical diagnosis.
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Label-free biosensors rely on the combination of specific bioreceptors with transducing elements that detect in real-time the presence of analytes in liquid samples.
“They rely on the combination of specific bioreceptors with transducing elements that detect in real-time the presence of analytes in the liquid samples (176).”
From Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis (2021) · cites this paper as [176]
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- Authors
- Soler, M., Huertas, C. S., & Lechuga, L. M.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST and CIBER-BBN, Bellaterra, Barcelona, Spain
- Corresponding author
- Soler, Maria
- Venue
- Expert Review of Molecular Diagnostics
- Publisher
- Informa UK Limited
- Published
- 2018-12-05
- Volume
- 19
- Issue
- 1
- Pages
- 71-81
- ISSN
- 1473-7159 (ISSN-L)
- 1744-8352
- OpenAlex
- W2902810208
- Cited by
- 236
- References
- 66
- Citations by year
- 2026: 18 · 2025: 31 · 2024: 32 · 2023: 31 · 2022: 34 · 2021: 51 · 2020: 31 · 2019: 8
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
- ddd.uab.cat
- Licence
- public-domain
- Locations
- Expert Review of Molecular Diagnostics (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, public-domain)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, public-domain)
- Figshare (submittedVersion, cc-by)
- Funders
- Centres de Recerca de Catalunya
- Institut Català de Nanociència i Nanotecnologia
- Generalitat de Catalunya
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España (SEV-2013-0295)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
- Keywords
- label-free biosensor, plasmonic biosensors, nanoplasmonics, point-of-care testing, portable diagnostic device, microfluidics, surface biofunctionalization, multiplexed sensors, disease biomarkers, protein detection, nucleic acid detection, cell detection, neoantigens
- MeSH terms
- Humans, Biosensing Techniques, Biomarkers, Point-of-Care Systems, Surface Plasmon Resonance, Molecular Diagnostic Techniques, Nanotechnology
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