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Oleanolic acid and related derivatives as medicinally important compounds
Open accessAbstract
Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity, anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on the properties of oleanolic acid and its derivatives.
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Cited by
Molecular activities, biosynthesis and evolution of triterpenoid saponins
Augustin, J. M., Kuzina, V., Andersen, S. B., & Bak, S. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.015 · Cited by 799
Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications
Singh, B., & Sharma, R. A. (2015) · 3 Biotech · doi:10.1007/s13205-014-0220-2 · Cited by 562
Pollier, J., & Goossens, A. (2012) · Phytochemistry · doi:10.1016/j.phytochem.2011.12.022 · Cited by 499
Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
Bishayee, A. (2011) · Frontiers in Bioscience · doi:10.2741/3730 · Cited by 330
Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea(Olive)
Hashmi, M. A., Khan, A., Hanif, M., Farooq, U., & Perveen, S. (2015) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2015/541591 · Cited by 275
Metadata
- Authors
- Sultana, N., & Ata, A.
- Venue
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2008-01-01
- Volume
- 23
- Issue
- 6
- Pages
- 739-756
- ISSN
- 1475-6366 (ISSN-L)
- 1475-6374
- OpenAlex
- W2143497433
- Cited by
- 211
- References
- 0
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sultana, N., & Ata, A. (2008). Oleanolic acid and related derivatives as medicinally important compounds. Journal of Enzyme Inhibition and Medicinal Chemistry. https://doi.org/10.1080/14756360701633187
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
