The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
Open accessAbstract
Breast cancer remains a major cause of death in the United States as well as the rest of the world. In view of the limited treatment options for patients with advanced breast cancer, preventive and novel therapeutic approaches play an important role in combating this disease. The plant-derived triterpenoids, commonly used for medicinal purposes in many Asian countries, posses various pharmacological properties. A large number of triterpenoids are known to exhibit cytotoxicity against a variety of tumor cells as well as anticancer efficacy in preclinical animal models. Numerous triterpenoids have been synthesized by structural modification of natural compounds. Some of these analogs are considered to be the most potent antiinflammatory and anticarcinogenic triterpenoids known. This review examines the potential role of natural triterpenoids and their derivatives in the chemoprevention and treatment of mammary tumors. Both in vitro and in vivo effects of these agents and related molecular mechanisms are presented. Potential challenges and future directions involved in the advancement of these promising compounds in the prevention and therapy of human breast cancer are also identified.
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2 retracted
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Cited by
Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
Hordyjewska, A., Ostapiuk, A., Horecka, A., & Kurzepa, J. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09623-1 · Cited by 298
Shanmugam, M. K., Dai, X., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.01.016 · Cited by 271
Self-citationBarreira, J. C. M., Arraibi, A. A., & Ferreira, I. C. F. R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.05.014 · Cited by 199
In-depth analysis of lupeol: delving into the diverse pharmacological profile
Dalimunthe, A., Carensia Gunawan, M., Dhiya Utari, Z., Dinata, M. R., Halim, P., Estherina S. Pakpahan, N., Sitohang, A. I., Sukarno, M. A., Yuandani, Harahap, Y., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1461478 · Cited by 50
Romero-Benavides, J. C., Bailon-Moscoso, N., Parra-Delgado, H., Ramirez, M. I., Villacis, J., Cabrera, H., Gonzalez-Arevalo, G., Cueva, R., Zentella-Dehesa, A., Ratovitski, E. A., et al. (2018) · Medicinal Chemistry Research · doi:10.1007/s00044-017-2106-4 · Cited by 17
Metadata
- Authors
- Bishayee, A.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2011
- Volume
- 16
- Issue
- 1
- Pages
- 980
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/3730
- OpenAlex
- W1996023050
- Cited by
- 330
- References
- 81
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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