The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Inhibition of SARS-CoV 3CL protease by flavonoids
Open accessAbstract
There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, we applied a flavonoid library to systematically probe inhibitory compounds against SARS-CoV 3CLpro. Herbacetin, rhoifolin and pectolinarin were found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. The interaction of the three flavonoids was confirmed using a tryptophan-based fluorescence method, too. An induced-fit docking analysis indicated that S1, S2 and S3' sites are involved in binding with flavonoids. The comparison with previous studies showed that Triton X-100 played a critical role in objecting false positive or overestimated inhibitory activity of flavonoids. With the systematic analysis, the three flavonoids are suggested to be templates to design functionally improved inhibitors.
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Cites
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574
SARS and MERS: recent insights into emerging coronaviruses
de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.81 · Cited by 3,510
Donnelly, C. A., Ghani, A. C., Leung, G. M., Hedley, A. J., Fraser, C., Riley, S., Abu-Raddad, L. J., Ho, L.-M., Thach, T.-Q., Chau, P., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13410-1 · Cited by 940 · cited 2×
“In herbacetin, total of four hydrogen bonds are formed 5 .011.”
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Cited by
Kneller, D. W., Phillips, G., O’Neill, H. M., Jedrzejczak, R., Stols, L., Langan, P., Joachimiak, A., Coates, L., & Kovalevsky, A. (2020) · Nature Communications · doi:10.1038/s41467-020-16954-7 · Cited by 474
Das, S., Sarmah, S., Lyndem, S., & Singha Roy, A. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1763201 · Cited by 380
A role for quercetin in coronavirus disease 2019 (COVID‐19)
Derosa, G., Maffioli, P., D'Angelo, A., & Di Pierro, F. (2021) · Phytotherapy Research · doi:10.1002/ptr.6887 · Cited by 303
Shree, P., Mishra, P., Selvaraj, C., Singh, S. K., Chaube, R., Garg, N., & Tripathi, Y. B. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1810778 · Cited by 269
Metadata
- Authors
- Jo, S., Kim, S., Shin, D. H., & Kim, M.-S.
- Venue
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2019-11-14
- Volume
- 35
- Issue
- 1
- Pages
- 145-151
- ISSN
- 1475-6366 (ISSN-L)
- 1475-6374
- OpenAlex
- W2985346127
- Cited by
- 685
- References
- 3
- FWCI
- 88.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jo, S., Kim, S., Shin, D. H., & Kim, M.-S. (2020). Inhibition of SARS-CoV 3CL protease by flavonoids. Journal of Enzyme Inhibition and Medicinal Chemistry. https://doi.org/10.1080/14756366.2019.1690480
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