Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents
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model of AD and ii) block mitophagy in a PRKN-independent manner, reinforcing the hypothesis of SGK1 inhibitors as neuroprotective chemical tools.
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Swiss ADME tool predicts SGK1 inhibitors GSK650394, EMD638683, and SI113 will be unlikely to cross BBB to access CNS.
“the Swiss ADME tool, predicts the SGK1 inhibitors GSK650394, EMD638683, and SI113 will be unlikely to cross the BBB to access the CNS”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Maestro et al., 2023
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EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency
Ackermann, T. F., Boini, K. M., Beier, N., Scholz, W., Fuchß, T., & Lang, F. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000331722 · Cited by 121 · see citing works
High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology
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Cited by
Sorted by citations
Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works
- Authors
- Maestro, I., Madruga, E., Boya, P., & Martínez, A.
- Affiliations
- Centro de Investigaciones, Biológicas Margarita Salas-CSIC
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2023-01-13
- Volume
- 38
- Issue
- 1
- Pages
- 2153841-2153841
- ISSN
- 1475-6366 (ISSN-L)
- 1475-6374
- PMC
- PMC9848319
- OpenAlex
- W4315928283
- Cited by
- 13
- References
- 3
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 1
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Enzyme Inhibition and Medicinal Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CB18/05/00040)
- Horizon 2020 Framework Programme (H2020-MSCA, 765912, PID2019, H2020-MSCA-ITN-2017, H2020-MSCA-ITN)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- SGK1 inhibitor, structural families, neuroprotection, Alzheimer's disease, mitophagy, kinase inhibitors
- MeSH terms
- Apoptosis, Protein Serine-Threonine Kinases, Neuroprotective Agents
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