EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency

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Impaired Regulation of Renal K+ Elimination in the sgk1-Knockout Mouse

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Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity

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Targeting SGK1 in diabetes

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Insulin receptors and renal sodium handling in hypertensive fructose-fed rats

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Androgens Are Necessary for the Development of Fructose-Induced Hypertension

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Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1

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Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship

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Salt, sodium channels, and SGK1

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SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess

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Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet

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Cloning of sgk serine-threonine protein kinase from shark rectal gland - a gene induced by hypertonicity and secretagogues

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Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure

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Molecular requirements for the regulation of the renal outer medullary K+ channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1

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Association of SGK1 Gene Polymorphisms with Type 2 Diabetes

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The Serum and Glucocorticoid Inducible Kinases SGK1-3 Stimulate the Neutral Amino Acid Transporter SLC6A19

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Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1

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Gene Therapy With Human Tissue Kallikrein Reduces Hypertension and Hyperinsulinemia in Fructose-Induced Hypertensive Rats

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Regulation of the Glutamate Transporter EAAT2 by PIKfyve

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Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na+ channels

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AF17 Competes with AF9 for Binding to Dot1a to Up-regulate Transcription of Epithelial Na+ Channel α

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Insulin-induced phosphorylation of ENaC correlates with increased sodium channel function in A6 cells

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Regulation of the Glutamate Transporter EAAT4 by PIKfyve

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The C-Terminal PDZ-Binding Motif in the Kv1.5 Potassium Channel Governs its Modulation by the Na+/H+ Exchanger Regulatory Factor 2

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The Metabolic Syndrome X And Peripheral Cortisol Synthesis

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Role of Serum- and Glucocorticoid-Inducible Kinase SGK1 in Glucocorticoid Regulation of Renal Electrolyte Excretion and Blood Pressure

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Salt-loading elevates blood pressure and aggravates insulin resistance in Wistar fatty rats: a possible role for enhanced Na+-H+exchanger activity

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Verapamil prevents insulin antinatriuresis in euglycemic rats

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Sgk1-Dependent Stimulation of Cardiac Na+/H+Exchanger Nhe1 by Dexamethasone

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PI3K signaling in cancer: beyond AKT

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Collecting Duct Principal Cell Transport Processes and Their Regulation

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The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

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AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

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SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling

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Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies

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The SGK1 inhibitor EMD638683, prevents Angiotensin II–induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation

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Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

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SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models

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SGK1

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Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells

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Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

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Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth

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SGK1 in Human Cancer: Emerging Roles and Mechanisms

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Therapeutic potential of serum and glucocorticoid inducible kinase inhibition

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The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

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SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition

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VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives

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Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683

Towhid, S. T., Liu, G., Ackermann, T. F., Beier, N., Scholz, W., Fuchß, T., Toulany, M., Rodemann, H. P., & Lang, F. J. W. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000354486 · Cited by 67 · see citing works

Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1

Lang, F., Stournaras, C., & Alesutan, I. (2014) · Molecular Membrane Biology · doi:10.3109/09687688.2013.874598 · Cited by 66 · see citing works

SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

Mason, J. A., Cockfield, J. A., Pape, D. J., Meissner, H., Sokolowski, M. T., White, T. C., Valentín López, J. C., Liu, J., Liu, X., Martínez-Reyes, I., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108821 · Cited by 64 · see citing works

Function and Regulation of the Epithelial Na + Channel ENaC

Rotin, D., & Staub, O. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200012 · Cited by 77 · see citing works

High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology

Elahi, M., Motoi, Y., Shimonaka, S., Ishida, Y., Hioki, H., Takanashi, M., Ishiguro, K., Imai, Y., & Hattori, N. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab115 · Cited by 57 · see citing works

Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease Models

Das, B., Sarkar, C., Rawat, V. S., Kalita, D., Deka, S., & Agnihotri, A. (2021) · Molecules · doi:10.3390/molecules26164996 · Cited by 58 · see citing works

AMP-activated kinase is a regulator of fibroblast growth factor 23 production

Glosse, P., Feger, M., Mutig, K., Chen, H., Hirche, F., Hasan, A. A., Gaballa, M. M. S., Hocher, B., Lang, F. J. W., & Föller, M. (2018) · Kidney International · doi:10.1016/j.kint.2018.03.006 · Cited by 56 · see citing works

The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star

Zhu, R., Yang, G., Cao, Z., Shen, K., Zheng, L., Xiao, J., You, L., & Zhang, T. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920940946 · Cited by 58 · see citing works

SGK1-FoxO1 Signaling Pathway Mediates Th17/Treg Imbalance and Target Organ Inflammation in Angiotensin II-Induced Hypertension

Du, Y.-N., Tang, X., Xu, L., Chen, W.-D., Gao, P., & Han, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01581 · Cited by 54 · see citing works

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Urich, R., Wishart, G., Kiczun, M., Richters, A., Tidten, N., Rauh, D., Sherborne, B. S., Wyatt, P. G., & Brenk, R. (2013) · ACS Chemical Biology · doi:10.1021/cb300729y · Cited by 52 · see citing works

Akt3 inhibits adipogenesis and protects from diet-induced obesity via WNK1/SGK1 signaling

Ding, L., Zhang, L., Biswas, S., Schugar, R. C., Brown, J. M., Byzova, T. V., & Podrez, E. A. (2017) · JCI Insight · doi:10.1172/jci.insight.95687 · Cited by 53 · see citing works

Targeting of SGK1 by miR-576-3p Inhibits Lung Adenocarcinoma Migration and Invasion

Greenawalt, E. J., Edmonds, M. D., Jain, N. M., Adams, C. M., Mitra, R., & Eischen, C. M. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0364 · Cited by 50 · see citing works

Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling

Ren, J., Han, X., Lohner, H., Liang, R., Liang, S., & Wang, H. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001455 · Cited by 49 · see citing works

Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention

Basnet, R., Gong, G. Q., Li, C., & Wang, M. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.07.001 · Cited by 46 · see citing works

SGK1 activation exacerbates diet-induced obesity, metabolic syndrome and hypertension

Sierra‐Ramos, C., Velázquez-García, S., Vastola-Mascolo, A., Hernández, G., Faresse, N., & de la Rosa, D. Á. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0275 · Cited by 42 · see citing works

Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy

Zhang, S., Wang, Y., Yu, M., Shang, Y., Chang, Y., Zhao, H. L., Kang, Y., Zhao, L., Xu, L., Zhao, X., et al. (2021) · Advanced Science · doi:10.1002/advs.202101485 · Cited by 44 · see citing works

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease

Singh, P. K., Singh, S., & Ganesh, S. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-05-0261 · Cited by 43 · see citing works

Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors

Jang, H., Park, Y. J., & Jang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1036844 · Cited by 43 · see citing works

Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure

Zhou, H., Gao, S., Duan, X., Liang, S., Scott, D. A., Lamont, R. J., & Wang, H. (2015) · The FASEB Journal · doi:10.1096/fj.15-270462 · Cited by 40 · see citing works

In Silico Identification and Biological Evaluation of Novel Selective Serum/Glucocorticoid-Inducible Kinase 1 Inhibitors Based on the Pyrazolo-Pyrimidine Scaffold

Ortuso, F., Amato, R., Artese, A., D’Antona, L., Costa, G., Talarico, C., Gigliotti, F., Bianco, C., Trapasso, F., Schenone, S., et al. (2014) · Journal of Chemical Information and Modeling · doi:10.1021/ci500235f · Cited by 37 · see citing works

Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population

Lang, F. J. W., Guelinckx, I., Lemetais, G., & Melander, O. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000479640 · Cited by 37 · see citing works

Role of SGK1 in the Osteogenic Transdifferentiation and Calcification of Vascular Smooth Muscle Cells Promoted by Hyperglycemic Conditions

Poetsch, F., Henze, L. A., Estepa, M., Moser, B., Pieske, B. M., Lang, F. J. W., Eckardt, K., Alesutan, I., & Voelkl, J. G. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197207 · Cited by 35 · see citing works

NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation

Liu, B., Zhang, J., Hong, Y., Li, N.-B., Liu, Y., Zhang, M., Wu, W., Zheng, H., Lampert, A., & Zhang, X. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02156-1 · Cited by 34 · see citing works

SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease

Lu, R., Zhang, Y., Zhao, H., Guo, R., Jiang, Z., & Guo, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.822303 · Cited by 35 · see citing works

Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders

Bezzerides, V. J., Zhang, A., Xiao, L., Simonson, B., Khedkar, S. A., Baba, S., Ottaviano, F. G., Lynch, S. N., Hessler, K., Rigby, A. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00413-3 · Cited by 34 · see citing works

Role of serum‐ and glucocorticoid‐inducible kinases in stroke

Inoue, K., Leng, T., Yang, T., Zeng, Z., Ueki, T., & Xiong, Z. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13650 · Cited by 30 · see citing works

Effect of Carbon Monoxide Donor CORM-2 on Vitamin D3 Metabolism

Feger, M., Fajol, A., Lebedeva, A., Meissner, A., Michael, D., Voelkl, J. G. J., Alesutan, I., Schleicher, E. D., Reichetzeder, C., Hocher, B., et al. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355730 · Cited by 29 · see citing works

Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced kidney injury

Sierra‐Ramos, C., Velázquez-García, S., Keşküş, A. G., Vastola-Mascolo, A., Rodríguez‐Rodríguez, A. E., Lima, S. L., Hernández, G., Navarro‐González, J. F., Porrini, E., Konu, Ö., et al. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00505.2020 · Cited by 28 · see citing works

SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity

Han, X., Ren, J., Lohner, H., Yakoumatos, L., Liang, R., & Wang, H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102036 · Cited by 28 · see citing works

Serum–Glucocorticoid Regulated Kinase 1 Regulates Macrophage Recruitment and Activation Contributing to Monocrotaline-Induced Pulmonary Arterial Hypertension

Xi, X., Liu, S., Shi, H., Yang, M. H., Qi, Y., Wang, J., & Du, J. (2014) · Cardiovascular Toxicology · doi:10.1007/s12012-014-9260-4 · Cited by 27 · see citing works

Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer

Liang, X., Lan, C. B., Zhou, J., Fu, W., Long, X., An, Y., Jiao, G., Wang, K., Li, Y., Xu, J., et al. (2017) · Journal of Cancer · doi:10.7150/jca.19566 · Cited by 28 · see citing works

Inhibition of SGK1 enhances mAR-induced apoptosis in MCF-7 breast cancer cells

Liu, G., Honisch, S., Liu, G., Schmidt, S., Pantelakos, S., Alkahtani, S. H., Toulany, M., Lang, F. J. W., & Stournaras, C. (2014) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.986982 · Cited by 27 · see citing works

Erratum To: The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

Bago, R., Sommer, E. M., Castel, P., Crafter, C., Bailey, F. P., Shpiro, N., Baselga, J. M., Cross, D. A. E., Eyers, P. A., & Alessi, D. R. (2016) · The EMBO Journal · doi:10.15252/embj.201670010 · Cited by 26 · see citing works

Janus kinase 3 regulates renal 25-hydroxyvitamin D 1α-hydroxylase expression, calcitriol formation, and phosphate metabolism

Umbach, A. T., Zhang, B., Daniel, C., Fajol, A., Velić, A., Hosseinzadeh, Z., Bhavsar, S. K., Bock, C. –., Kandolf, R., Pichler, B. J., et al. (2014) · Kidney International · doi:10.1038/ki.2014.371 · Cited by 25 · see citing works

SGK1 inhibitor reverses hyperglycemia partly through decreasing glucose absorption

Li, P., Hao, Y., Pan, F., Zhang, M., Ma, J.-Q., & Zhu, D. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0285 · Cited by 25 · see citing works

Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases

Maestro, I., Boya, P., & Martı́nez, A. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1730328 · Cited by 22 · see citing works

SGK1, autophagy and cancer: an overview

Ghani, M. J. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06836-6 · Cited by 22 · see citing works

Inhibition of Serum- and Glucocorticoid-Regulated Protein Kinase-1 Aggravates Imiquimod-Induced Psoriatic Dermatitis and Enhances Proinflammatory Cytokine Expression through the NF-kB Pathway

Meng, Q., Bai, M., Guo, M., Li, Z., Liu, W., Fan, X., Sun, R., Yang, X.-R., Ding-fen, Y., Shi, Y., et al. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.12.013 · Cited by 21 · see citing works

Function and Regulation of the Epithelial Na + Channel ENaC

Rotin, D., & Staub, O. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00172.x · Cited by 21 · see citing works

TGF 1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells

Schmidt, S., Schneider, S., Yang, W., Liu, G., Schmidt, E. M., Schmid, E., Mia, S., Brucker, S. Y., Stournaras, C., Wallwiener, D. R., et al. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat066 · Cited by 21 · see citing works

Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism

Rassi-Cruz, M., Maria, A. G., Faucz, F. R., London, E., Vilela, L. A. P., de Santana, L. S., Benedetti, A. F. F., Goldbaum, T. S., Tanno, F. Y., Srougi, V., et al. (2020) · Endocrine Related Cancer · doi:10.1530/erc-20-0384 · Cited by 21 · see citing works

Regulation of methylglyoxal-elicited leukocyte recruitment by endothelial SGK1/GSK3 signaling

Su, Y., Qadri, S. M., Cayabyab, F. S., Wu, L., & Liu, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.06.018 · Cited by 20 · see citing works

Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds

Gong, G. Q., Wang, K., Dai, X., Zhou, Y., Basnet, R., Chen, Y., Yang, D., Lee, W.-J., Buchanan, C. M., Flanagan, J. U., et al. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0087-6 · Cited by 19 · see citing works

ENaC Modulators and Renal Disease

de la Rosa, D. Á., Navarro‐González, J. F., & Giráldez, T. (2013) · Current Molecular Pharmacology · doi:10.2174/1874467211306010005 · Cited by 17 · see citing works

The functional duality of SGK1 in the regulation of hyperglycemia

Yang, C., Li, J., Sun, F., Zhou, H., Yang, J., & Yang, C. (2020) · Endocrine Connections · doi:10.1530/ec-20-0225 · Cited by 18 · see citing works

Up-Regulation of Kir2.1 (KCNJ2) by the Serum & Glucocorticoid Inducible SGK3

Muñoz, C., Pakladok, T., Almilaji, A., Elvira, B., Decher, N., Shumilina, E. V., & Lang, F. J. W. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358629 · Cited by 17 · see citing works

Serum‐ and glucocorticoid‐inducible kinase 1 promotes insulin resistance in adipocytes via degradation of insulin receptor substrate 1

Zhang, M., Chen, H., Liu, M., Zhu, K., Yan, H., Zhu, D., & Li, P. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3451 · Cited by 16 · see citing works

Common Variants in Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and Blood Pressure Responses to Dietary Sodium or Potassium Interventions: A family-Based Association Study

Chu, C., Wang, Y., Wang, M., Mu, J., Liu, F., Wang, L., Ren, K., Wang, D., & Yuan, Z. (2015) · Kidney & Blood Pressure Research · doi:10.1159/000368518 · Cited by 17 · see citing works

Intestinal Na+ Loss and Volume Depletion in JAK3-Deficient Mice

Umbach, A. T., Luo, D., Bhavsar, S. K., Hosseinzadeh, Z., & Lang, F. J. W. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355731 · Cited by 16 · see citing works

Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma

Jiang, F., Liu, H., Peng, F., Liu, Z., Ding, K., Song, J., Li, L., Chen, J., Shao, Q., Yan, S., et al. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0430 · Cited by 16 · see citing works

Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review

Noor, S., Mohammad, T., Ashraf, G. M., Farhat, J., Bilgrami, A. L., Eapen, M. S., Sohal, S. S., Yadav, D. K., & Hassan, M. I. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.10.165 · Cited by 16 · see citing works

Noncanonical Form of ERAD Regulates Cardiac Hypertrophy

Blackwood, E. A., MacDonnell, L. F., Thuerauf, D. J., Bilal, A. S., Murray, V. B., Bedi, K. C., Margulies, K. B., & Glembotski, C. C. (2022) · Circulation · doi:10.1161/circulationaha.122.061557 · Cited by 16 · see citing works

Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC Therapy

Guerriero, I., Monaco, G., Coppola, V., & Orlacchio, A. (2020) · Pharmaceuticals · doi:10.3390/ph13110413 · Cited by 16 · see citing works

Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes

Wester, M., Heller, A., Gruber, M. A., Maier, L. S., Schach, C., & Wagner, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222341 · Cited by 16 · see citing works

Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis

Halland, N., Schmidt, F., Weiß, T., Li, Z., Czech, J., Saas, J., Ding‐Pfennigdorff, D., Dreyer, M., Strübing, C., & Nazaré, M. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01601 · Cited by 15 · see citing works

Upregulation of Intestinal NHE3 Following Saline Ingestion

Pasham, V., Rotte, A., Gu, S., Yang, W., Bhandaru, M., Rexhepaj, R., Pathare, G., & Lang, F. J. W. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000343401 · Cited by 14 · see citing works

Upregulation of Store Operated Ca2+ Channel Orai1, Stimulation of Ca2+ Entry and Triggering of Cell Membrane Scrambling in Platelets by Mineralocorticoid DOCA

Liu, G., Liu, G., Alzoubi, K., Umbach, A. T., Pelzl, L., Borst, O., Gawaz, M., & Lang, F. J. W. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355750 · Cited by 14 · see citing works

Serum and Glucocorticoid Inducible Kinase 1-Sensitive Survival, Proliferation and Migration of Rhabdomyosarcoma Cells

Schmid, E., Stagno, M. J., Yan, J., Schleicher, S., Yu, W., Honisch, S., Lang, F. J. W., Fuchs, J., & Seitz, G. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000481842 · Cited by 14 · see citing works

Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain

Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works

Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents

Maestro, I., Madruga, E., Boya, P., & Martínez, A. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2022.2153841 · Cited by 13 · see citing works

SGK1 inhibition attenuated the action potential duration in patient- and genotype-specific re-engineered heart cells with congenital long QT syndrome

Kim, M., Das, S., Tester, D. J., Pradhananga, S., Hamrick, S. K., Gao, X., Srinivasan, D. K., Sager, P. T., & Ackerman, M. J. (2023) · Heart Rhythm O2 · doi:10.1016/j.hroo.2023.02.003 · Cited by 13 · see citing works

Endothelial Cell Serum and Glucocorticoid Regulated Kinase 1 (SGK1) Mediates Vascular Stiffening

Zhang, L., Sun, Z., Yang, Y., Mack, A., Rodgers, M., Aroor, A. R., Jia, G., Sowers, J. R., & Hill, M. A. (2023) · Metabolism · doi:10.1016/j.metabol.2024.155831 · Cited by 12 · see citing works

Aldosterone-induced protein kinase signalling and the control of electrolyte balance

Harvey, B. J., & Thomas, W. (2017) · Steroids · doi:10.1016/j.steroids.2017.10.009 · Cited by 12 · see citing works

Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics

Shi, G., Wang, Q., Zhou, X., Li, J., Liu, H., Gu, J., Wang, H., Wu, Y. Z., Ding, L., Ni, S., et al. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx006 · Cited by 12 · see citing works

Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord

Yasukochi, S., Kusunose, N., Matsunaga, N., Koyanagi, S., & Ohdo, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114411 · Cited by 12 · see citing works

Increased intracellular Cl− concentration mediates Trichomonas vaginalis-induced inflammation in the human vaginal epithelium

Xu, J.-B., Zhang, Y., Huang, J., Lu, S.-J., Sun, Q., Chen, P.-X., Jiang, P., Qiu, Z.-E., Jiang, F., Zhu, Y., et al. (2019) · International Journal for Parasitology · doi:10.1016/j.ijpara.2019.04.005 · Cited by 11 · see citing works

Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer’s patient-derived cortical neurons

Saleem, K., Xiao, Z., Zhu, B., Ren, Y., Yan, Z., & Feng, J. (2026) · Molecular Psychiatry · doi:10.1038/s41380-025-03225-4 · Cited by 10 · see citing works

Probing 2H‐Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

Schoene, J., Gazzi, T., Lindemann, P., Christmann, M., Volkamer, A., & Nazaré, M. (2019) · ChemMedChem · doi:10.1002/cmdc.201900328 · Cited by 10 · see citing works

Potential implication of SGK1-dependent activity change in BV-2 microglial cells.

Asai, H., Inoue, K., Sakuma, E., Shinohara, Y., & Ueki, T. (2018) · Europe PMC (PubMed Central) · Cited by 10 · see citing works

SGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFκB pathway

Zhang, Y., Zhang, D., Meng, T., Tian, P., Chen, J., Liu, A., Zheng, Y., & Su, G. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111151 · Cited by 9 · see citing works

The role of serum and glucocorticoid-regulated kinase 1 in cellular signaling: Implications for drug development

Gulzar, M., Noor, S., Hasan, G. M., & Hassan, M. I. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128725 · Cited by 9 · see citing works

SGK1: master and commander of the fate of helper T cells

Norton, M., & Screaton, R. A. (2014) · Nature Immunology · doi:10.1038/ni.2875 · Cited by 9 · see citing works

Serum- and glucocorticoid-inducible kinase 1 activity in ventral tegmental area dopamine neurons regulates cocaine conditioned place preference but not cocaine self-administration

Doyle, M. A., Bali, V., Eagle, A. L., Stark, A. R., Fallon, B., Neve, R. L., Robison, A. J., & Mazei-Robison, M. S. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01032-3 · Cited by 9 · see citing works

Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1

Patel, C. H., Heikamp, E., Xu, W., Sun, I., Oh, M. H., Sun, I.-M., Wen, J., Tam, A. J., Blosser, R. L., & Powell, J. D. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100669 · Cited by 8 · see citing works

SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms

Martín-Batista, E., Maglio, L. E., Armas-Capote, N., Hernández, G., de la Rosa, D. Á., & Giráldez, T. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105317 · Cited by 8 · see citing works

Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism

Fahkri, H., Zhang, B., Fajol, A., Hernando, N., Elvira, B., Mannheim, J. G., Pichler, B. J., Daniel, C., Amann, K., Hirao, A., et al. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1625-9 · Cited by 7 · see citing works

Identification of Novel Inhibitors Targeting SGK1 via Ensemble-Based Virtual Screening Method, Biological Evaluation and Molecular Dynamics Simulation

Zhang, H., Shen, C., Zhang, H.-R., Qi, H.-Z., Hu, M., & Luo, Q.-Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158635 · Cited by 6 · see citing works

Unlocking SGK1 inhibitor potential of bis-[1-N,7-N, pyrazolo tetraethoxyphthalimido{-4-(3,5-Dimethyl-4-(spiro-3-methylpyazolo)-1,7-dihydro-1H-dipyrazolo[3,4-b;4',3'-e]pyridin-8-yl)}]p-disubstituted phenyl compounds: a computational study

Verma, A. K., Ahmed, S. F., Hossain, M. S., Bhojiya, A. A., Upadhyay, S. K., Srivastava, A. K., Singh, N., Harina, H., Rahaman, M. M., & Bahadur, N. M. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1988711 · Cited by 6 · see citing works

AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms

Cabrera, J. C., Dang, H., Graves, A. C., Zhang, Z., Torres-Castillo, J. L., Li, K., King, Z. T., Liu, P., Aubé, J., Bear, J. E., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.10.008 · Cited by 5 · see citing works

Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2

Wu, Y., Wang, H., Li, Y., Li, Y., Liang, Y., Zhong, G., & Zhang, Q. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00990-3 · Cited by 4 · see citing works

Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats

Qian, J., Mummalaneni, S., Phan, T. T., Heck, G. L., DeSimone, J. A., West, D., Mahavadi, S., Hojati, D., Murthy, K. S., Rhyu, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171335 · Cited by 4 · see citing works

Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1

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Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet

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Abstract P036: Salt-inducible Kinase (SIK): A Pharmacological Target Of Salt-sensitive Hypertension

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Abstract P214: Serum Glucocorticoid Kinase 1 and Sympathetic Nerve Activity in Salt-Sensitive Hypertension.

Beusecum, J. P. V., Barbaro, N. R., Xiao, L., Pandey, A. K., Harrison, D. G., & Kirabo, A. (2018) · Hypertension · doi:10.1161/hyp.72.suppl_1.p214

Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced hypertension and kidney injuryPreprint

Sierra‐Ramos, C., Velázquez-García, S., Keşküş, A. G., Vastola-Mascolo, A., Rodríguez‐Rodríguez, A. E., Lima, S. L., Hernández, G., Navarro‐González, J. F., Porrini, E., Konu, Ö., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.08.191874