Bioactive caffeic acid esters from Glycyrrhiza glabra
Abstract
Thin layer chromatography bioautography (using DPPH spray reagent) guided fractionation of Glycyrrhiza glabra led to the isolation of two caffeic acid derivative esters, viz. eicosanyl caffeate (1) and docosyl caffeate (2). The two compounds exhibited potent elastase inhibitory activity, with IC(50) values of 0.99 microg mL(-1) and 1.4 microg mL(-1) for 1 and 2, respectively. The compounds also showed moderate antioxidant activity in DPPH and ABTS scavenging assays. The results indicate a possible role of caffeic acid derivatives, in addition to flavonoids in the anti-ulcer properties of G. glabra.
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Eicosanyl caffeate and docosyl caffeate from G. glabra roots have potent elastase inhibitory activity with IC50 values of 0.99 μg/mL and 1.4 μg/mL, respectively.
“Moreover, eicosanyl caffeate and docosyl caffeate, two long-chain caffeoyl esters isolated by ethyl acetate extract of G. glabra roots displayed by a spectrophotometric assay a potent elastase inhibitory activity, an additional target to prevent aging and wrinkles formation [60], with IC 50 values of 0.99 µg/mL and 1.4 µg/mL, respectively [61].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [61]
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Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
- Authors
- Dey, S., Deepak, M., Setty, M., D’Souza, P., Agarwal, A., & Sangli, G. K.
- Affiliations
- Natural Remedies (India) (IN)
- R&D Centre, Natural Remedies Pvt. Ltd.
- Manipal Academy of Higher Education (IN)
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2009-11-17
- Volume
- 23
- Issue
- 18
- Pages
- 1657-1663
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W1991250985
- Cited by
- 21
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- licorice, caffeic acid esters, elastase inhibition, antioxidant activity, antiulcer activity, natural product isolation
- MeSH terms
- Antioxidants, Caffeic Acids, Enzyme Activation, Enzyme Inhibitors, Esters, Glycyrrhiza, Pancreatic Elastase, Plant Extracts, Molecular Structure, Inhibitory Concentration 50
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