In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages
Abstract
Biological properties of clove have been reported, but little is known about its effect on the immune system. This work was aimed to investigate the effect in vivo of a water-soluble part of hydroalcoholic extract of clove on pro-inflammatory cytokines (IL-1beta and IL-6) production by macrophages of BALB/c mice. The action of the essential oil of clove on the production of these cytokines macrophages was also investigated in vitro. The chemical compositions of the extract and of the oil were also investigated. Treatment of mice with water extract of clove was found to inhibit macrophages to produce both IL-1beta and IL-6. The essential oil of clove also inhibited the production of these cytokines in vitro. Eugenol was found to be the major component of the clove extract and essential oil, and probably is the causative agent of cytokine inhibition. Taken together, these data suggest an anti-inflammatory action of this spice.
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Eugenol, the main component of Syzygium aromaticum essential oil, has similar cytokine-suppressing properties.
“The same authors attributed similar properties to the eugenol, the main component present in the essential oil of Syzygium aromaticum (L.) Merr. et Perry (clove) [118].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [118]
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References 25 · Cited by 69
- Authors
- Rodrigues, T. G., Fernandes, A., Sousa, J. P. B., Bastos, J. K., & Sforcin, J. M.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Sforcin, J.M.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2009-03-10
- Volume
- 23
- Issue
- 4
- Pages
- 319-326
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2115356077
- Cited by
- 69
- References
- 25
- Citations by year
- 2025: 4 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Syzygium aromaticum, inflammatory cytokines, IL-1β, interleukin-6, macrophages, anti-inflammatory activity, eugenol, essential oils, hydroalcoholic extract, immunomodulation, chemical composition
- MeSH terms
- Animals, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Eugenol, Lipopolysaccharides, Macrophages, Male, Mice, Inbred BALB C, Oils, Volatile, Plant Extracts, Interleukin-6, Cytokines, Syzygium, Mice, Interleukin-1beta
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