Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum
Open accessAbstract
The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20 mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound anti-microbial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.
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Sarcophyton is one of the most widely distributed soft coral genera in the tropical and sub-tropical oceans, and approximately 30 species from this genus have been collected and tested for the presence of bioactive secondary metabolites.
“Sarcophyton is one of the most widely distributed soft coral genera in the tropical and sub-tropical oceans, and approximately 30 species from this genus have been collected and tested for the presence of bioactive secondary metabolites, i.e., fatty acids (arachidonic, eicosapentaenoic, docosahexaenoic acids) that showed cytotoxic activity against brine shrimp in dose-dependent manner (LC50 of 96.”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [153]
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
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- Authors
- Gomaa, M. N., Soliman, K., Ayesh, A., Abd El-Wahed, A., Hamza, Z., Mansour, H. M., Khalifa, S. A. M., Mohd Ali, H. B., & El-Seedi, H. R.
- Affiliations
- King Abdulaziz University (SA)
- Pharmacognosy Division, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Box 574, SE-751 24 Uppsala, Sweden
- National Research Centre (EG)
- University of Karachi (PK)
- Karolinska University Hospital (SE)
- Centre for Natural Products and Drug Discovery (CENAR), Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
- Uppsala University (SE)
- Corresponding author
- El-Seedi, Hesham R.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2015-07-17
- Volume
- 30
- Issue
- 6
- Pages
- 729-734
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2281222998
- Cited by
- 31
- References
- 17
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Greater South Information System
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Physical Sciences › Environmental Science › Ecology › Coral and Marine Ecosystems Studies
- Keywords
- Sarcophyton trocheliophorum, soft coral, marine natural products, antibacterial activity, terpenoids, secondary metabolites, bioassay-guided fractionation, minimum inhibitory concentration, Gram-positive bacteria, Gram-negative bacteria, Red Sea
- MeSH terms
- Alkynes, Animals, Anti-Bacterial Agents, Bacillus cereus, Escherichia coli, Furans, Gas Chromatography-Mass Spectrometry, Microbial Sensitivity Tests, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus, Terpenes, Indian Ocean, Anthozoa
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