Phytoecdysteroids-containing extract from Stachys hissarica plant and its wound-healing activity
Abstract
A number of phytoecdysteroid compounds, such as ecdysterone, polipodin V, 2-deoxy-20-hydroxyecdysone, integristeron A and 2-deoxydizon were isolated from Stachys hissarica plant and their structures were confirmed by NMR, mass and IR spectroscopy. In addition, the biological activity of the S. hissarica plant's extract was tested on rats for wound healing activity. It was shown that the extract at repeated oral (per os) administration at a dose of 10 mg/kg speeds up the healing process of linear skin wounds in rats. The wound-healing activity of S. hissarica extract is confirmed to be effective and exceeds known drug methyluracil (2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine), especially in case of alloxan induced diabetic animals.
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In mice/rat excretion, 14-deoxy-20-hydroxyecdysone, poststerone and 14-deoxypoststerone were reported.
“in mice/rat excretion: 14‐deoxy‐20‐hydroxyecdysone, poststerone and 14‐deoxypoststerone. 7 , 13”
The PE-rich plant Stachys hissarica exhibited in vivo wound-healing activity in rats, more effective than methyluracil, especially in alloxan-induced diabetic animals.
“A PE-rich plant, Stachys hissarica, has exhibited in vivo wound-healing activity in rats. The wound-healing activity of this plant is more effective than the known drug methyluracil (2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine), especially in the case of alloxan-induced diabetic animals168.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [168]
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References 13 · Cited by 24
- Authors
- Ramazanov, N. S., Bobayev, I. D., Yusupova, U. Y., Aliyeva, N. K., Egamova, F. R., Yuldasheva, N. K., & Syrov, V. N.
- Affiliations
- Academy of Sciences Republic of Uzbekistan (UZ)
- Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan
- Kokand State Pedagogical Institute named after Mukimi (UZ)
- Corresponding author
- Ramazanov, Nurmurod Sh.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2016-07-11
- Volume
- 31
- Issue
- 5
- Pages
- 593-597
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2468032879
- Cited by
- 24
- References
- 13
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Keywords
- phytoecdysteroids, 20-hydroxyecdysone, wound healing, skin wounds, alloxan-induced diabetes, methyluracil, medicinal plants, natural product isolation
- MeSH terms
- Alloxan, Animals, Diabetes Mellitus, Experimental, Plant Extracts, Wound Healing, Ecdysteroids, Stachys, Rats
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