The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Bacosides enrichment does not improve the anti-amnesic effect of Bacopa monnieri: behavioural and biochemical evidences
Abstract
Bacopa monnieri (L.) Wettst. (BM) has been traditionally used in Ayurveda for improving memory and cognitive deficits which is also evidenced through experimental and clinical studies. The neuropharmacological properties of BM are attributed to “bacosides”, a complex mixture of saponin compounds. BM extracts enriched with bacosides offers commercial advantage due to perceived higher efficacy. However, there is no scientific data to support the same. In the present study, methanolic extract of BM (BME) was compared with bacosides enriched (BME-EF) vis a vis bacosides free fraction (BME-FF). Potential antioxidant and cholinesterase inhibitory activity has been evaluated using in vitro and in vivo methods. BME showed not only the highest anti-amnesic efficacy but also antioxidant and cholinesterase inhibitory activity, followed by either BME-FF or BME-EF. Interestingly, no significant differences were found in between the groups. These findings dispel the notion that bacosides enrichment enhances anti-amnesic efficacy and also suggests the contribution of other components.
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Bacopa monnieri and Olax subscorpioidea significantly inhibited AChE activity and oxidative stress and improved memory and neuronal integrity.
“Bacopa monnieri and Olax subscorpioidea have demonstrated significant inhibition of AChE activity and oxidative stress alongside improvements in memory and neuronal integrity [38,39].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [38]
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Cites
Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
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Protective activity of Bacopa monniera Linn. on nicotine‐induced toxicity in mice
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Artocarpin-enriched extract reverses collagen metabolism in UV-exposed fibroblasts
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- Kishore K, 2005, Indian J Exp Biol, 43, 640
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ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35
Metadata
- Authors
- Arora, R., Kumar, R., Agarwal, A., & Gupta, Y. K.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Natural Remedies (India) (IN)
- Corresponding author
- Gupta, Y. K.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2020-09-14
- Volume
- 35
- Issue
- 24
- Pages
- 6054-6057
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W3085025809
- Cited by
- 0
- References
- 10
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- Bacopa monnieri, bacosides, anti-amnesic effect, memory enhancement, antioxidant activity, cholinesterase inhibition, methanol extract, saponins, cognitive impairment, Ayurveda
- MeSH terms
- Medicine, Ayurvedic, Plant Extracts, Saponins, Triterpenes, Bacopa
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