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Comparative deposition of inhaled aerosols in experimental animals and humans: A review
Abstract
The biological effects of inhaled aerosols are often related to their site(s) of deposition within the respiratory tract. However, deposition patterns may differ between humans and those experimental animals commonly used in inhalation toxicology studies, making cross-species risk extrapolations difficult. This paper reviews the factors that control deposition and synthesizes much of the available data on comparative regional deposition.
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Citations
Cited by
Influence of particle size on regional lung deposition – What evidence is there?
Carvalho, T. C., Peters, J. I., & Williams III, R. O. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.040 · Cited by 614
Intercomparison of experimental regional aerosol deposition data
STAHLHOFEN, W., RUDOLF, G., & JAMES, A. C. (1989) · Journal of Aerosol Medicine · doi:10.1089/jam.1989.2.285 · Cited by 423
Olfactory dysfunction in Parkinson's disease.
Hawkes, C. H., Shephard, B. C., & Daniel, S. E. (1997) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.5.436 · Cited by 396
Health Effects of Mycotoxins in Indoor Air: A Critical Review
Robbins, C. A., Swenson, L. J., Nealley, M. L., Kelman, B. J., & Gots, R. E. (2000) · Applied Occupational and Environmental Hygiene · doi:10.1080/10473220050129419 · Cited by 197
Metadata
- Authors
- Schlesinger, R. B.
- Venue
- Journal of Toxicology and Environmental Health
- Publisher
- Informa UK Limited
- Published
- 1985-01
- Volume
- 15
- Issue
- 2
- Pages
- 197-214
- ISSN
- 0098-4108 (ISSN-L)
- OpenAlex
- W2039427369
- Cited by
- 265
- References
- 0
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Comparative deposition of inhaled aerosols in experimental animals and humans: A review. https://app.cochat.ai/papers/10.1080/15287398509530647
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- Schlesinger, R. B. (1985). Comparative deposition of inhaled aerosols in experimental animals and humans: A review. Journal of Toxicology and Environmental Health. https://doi.org/10.1080/15287398509530647
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
