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Interactive effects of fluoride and aluminum uptake and accumulation in bones of rabbits administered both agents in their drinking water
Abstract
Fluoride (F) and aluminum (Al), which are known to form a strong complex, are both present in finished drinking water. The effect of F and AI on one another's tissue accumulation was determined using adult male New Zealand white rabbits. Thirty-six rabbits (three per group) were given Purina Rabbit Chow and drinking water containing no F or AI, F alone (1, 4, or 50 ppm F as NaF), Al alone, (100 or 500 ppm Al as AlCl3), or a combination of F and Al, ad libitum for 10 wk. None of these treatments altered food intake or weight gain in these rabbits. However, rabbits treated with 1 ppm F and 500 ppm Al consumed significantly less water than control rabbits. The F accumulation in plasma, urine, incisors, and tibia was increased as the F addition to the drinking water increased within groups receiving a single concentration of Al. In contrast, F accumulation in plasma, urine, incisors, and tibia decreased as the Al concentration increased within groups receiving a single F concentration, indicative of decreased intestinal absorption. Importantly, Al levels in tibia were significantly increased by the addition of F to the drinking water, even in animals receiving no Al in their drinking water. The effect of F on Al accumulation in bone was confirmed by our evaluating Al levels in sterna harvested from rats treated with 0 or 79 ppm F (as NaF in the drinking water) in a study conducted by the National Toxicology Program (Bucher et al., 1991). Therefore, some of the osteotoxicity seemi…
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“Long-term oral exposure to Al results in an increase in Al levels in the bone (Ahn et al., 1995; Konishi et al., 1996) that is responsible for the bone disease.”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Ahn et al., 1995
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Longterm oral exposure to Al results in an increase in Al levels in the bone (Ahn et al., 1995; Konishi et al., 1996) that is responsible for the bone disease.”
Background
Metadata
- Authors
- Ahn, H., Fulton, B., Moxon, D., & Jeffery, E. H.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Venue
- Journal of Toxicology and Environmental Health
- Publisher
- Informa UK Limited
- Published
- 1995-03
- Volume
- 44
- Issue
- 3
- Pages
- 337-350
- ISSN
- 0098-4108 (ISSN-L)
- OpenAlex
- W2092894960
- Cited by
- 33
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 2
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Toxicology and Environmental Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- fluoride, aluminum, bone accumulation, drinking water contamination, osteotoxicity, tibia, sterna, intestinal absorption, rabbits, rats
- MeSH terms
- Aluminum Chloride, Aluminum, Animals, Biological Availability, Body Weight, Chlorides, Dose-Response Relationship, Drug, Drinking, Drug Interactions, Eating, Female, Fluorides, Incisor, Liver, Male, Rabbits, Sodium Fluoride, Sternum, Tibia, Tissue Distribution, Aluminum Compounds
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