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The age of a mutation in a general coalescent tree
Abstract
Kimura and Ohta showed that the expected age of a neutral mutation observed to be of frequency x in a population is We put this classical result in a general coalescent process context that allows questions to be asked about mutations in a sample, as well as in the population. In the general context the population size may vary back in time. Assuming an infmitely-many-sites model of mutation, we find the distribution of the number of mutant genes at a particular site in a sample; the probability that an allele at that site of a given frequency is ancestral; the distribution of the age of a mutation given its frequency in a sample, or population; and the distribution of the time to the most recent common ancestor, given the frequency of a mutation in a sample, or in the population
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Citations
Cites
THE AGE OF A NEUTRAL MUTANT PERSISTING IN A FINITE POPULATION
Kimura, M., & Ohta, T. (1973) · Genetics · doi:10.1093/genetics/75.1.199 · Cited by 241
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Metadata
- Authors
- Griffiths, R. C., & Tavaré, S.
- Venue
- Communications in Statistics. Stochastic Models
- Publisher
- Informa UK Limited
- Published
- 1998-01
- Volume
- 14
- Issue
- 1-2
- Pages
- 273-295
- ISSN
- 0882-0287 (ISSN-L)
- OpenAlex
- W2146638375
- Cited by
- 241
- References
- 1
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Griffiths, R. C., & Tavaré, S. (1998). The age of a mutation in a general coalescent tree. Communications in Statistics. Stochastic Models. https://doi.org/10.1080/15326349808807471
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
