THE AGE OF A NEUTRAL MUTANT PERSISTING IN A FINITE POPULATION
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Formulae for the mean and the mean square age of a neutral allele which is segregating with frequency x in a population of effective size Ne have been obtained using the diffusion equation method, for the case of 4Nev<1 where v is the mutation rate. It has been shown that the average ages of neutral alleles, even if their frequencies are relatively low, are quite old. For example, a neutral mutant whose current frequency is 10% has the expected age roughly equal to the effective population size Ne and the standard deviation 1.4Ne (in generations), assuming that this mutant has increased by random drift from a very low frequency. Also, formulae for the mean "first arrival time" of a neutral mutant to a certain frequency x have been presented. In addition, a new, approximate method has been developed which enables us to obtain the condition under which frequencies of "rare" polymorphic alleles among local populations are expected to be uniform if the alleles are selectively neutral.—It was concluded that exchange of only a few individuals on the average between adjacent colonies per generation is enough to bring about such a uniformity of frequencies.
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Humans have limited genetic variation: the heterozygosity rate for single-nucleotide polymorphisms (SNPs) is ~1 in 1000 bases.
“As predicted by classical theory (29), humans have limited genetic variation: The heterozygosity rate for single-nucleotide polymorphisms (SNPs) is ~1 in 1000 bases (30–32).”
From Genetic Mapping in Human Disease (2008) · cites this paper as [29]
Cites
THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION
Kimura, M., & Crow, J. F. (1964) · Genetics · doi:10.1093/genetics/49.4.725 · Cited by 2,690 · see citing works
Self-citationDiffusion models in population genetics
Kimura, M. (1964) · Journal of Applied Probability · doi:10.2307/3211856 · Cited by 771 · see citing works
Self-citationSELECTION FOR HETEROZYGOTES IN SMALL POPULATIONS
Robertson, A. (1962) · Genetics · doi:10.1093/genetics/47.9.1291 · Cited by 258 · see citing works
Pattern of neutral polymorphism in a geographically structured population
Kimura, M., & Maruyama, T. (1971) · Genetics Research · doi:10.1017/s0016672300012520 · Cited by 183 · see citing works
Self-citationDevelopment of associative overdominance through linkage disequilibrium in finite populations
Ohta, T., & Kimura, M. (1970) · Genetics Research · doi:10.1017/s0016672300002391 · Cited by 114 · see citing works
Self-citation
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Sorted by citations
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works
Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
Li, J. Z., Absher, D. M., Tang, H., Southwick, A. M., Casto, A. M., Ramachandran, S., Cann, H. M., Barsh, G. S., Feldman, M. W., Cavalli-Sforza, L. L., et al. (2008) · Science · doi:10.1126/science.1153717 · Cited by 1,947 · see citing works
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452 · see citing works
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
Fu, W., O’Connor, T. D., Jun, G., Kang, H. M., Abecasis, G. R., Leal, S. M., Gabriel, S., Rieder, M. J., Altshuler, D., Shendure, J., et al. (2012) · Nature · doi:10.1038/nature11690 · Cited by 951 · see citing works
Line-of-descent and genealogical processes, and their applications in population genetics models
Tavaré, S. (1984) · Theoretical Population Biology · doi:10.1016/0040-5809(84)90027-3 · Cited by 581 · see citing works
Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes
Stephens, J. C., Reich, D. E., Goldstein, D. B., Shin, H. D., Smith, M. W., Carrington, M., Winkler, C., Huttley, G. A., Allikmets, R., Schriml, L., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301867 · Cited by 520 · see citing works
Evidence of positive selection acting at the human dopamine receptor D4 gene locus
Ding, Y. C., Chi, H. C., Grady, D., Morishima, A., Kidd, J., Kidd, K., Flodman, P., Spence, M., Schuck, S., Swanson, J., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012464099 · Cited by 506 · see citing works
Linck, E. B., & Battey, C. J. (2019) · Molecular Ecology Resources · doi:10.1111/1755-0998.12995 · Cited by 395 · see citing works
Ancestral Inference in Population Genetics
Griffiths, R., & Tavaré, S. (1994) · Statistical Science · doi:10.1214/ss/1177010378 · Cited by 387 · see citing works
Probability Models for DNA Sequence Evolution
Durrett, R. (2002) · Probability and its applications · doi:10.1007/978-1-4757-6285-3 · Cited by 366 · see citing works
Inferring whole-genome histories in large population datasets
Kelleher, J., Wong, Y., Wohns, A. W., Fadil, C., Albers, P. K., & McVean, G. (2019) · Nature Genetics · doi:10.1038/s41588-019-0483-y · Cited by 313 · see citing works
Extent and Distribution of Linkage Disequilibrium in Three Genomic Regions
Abecasis, G. R., Noguchi, E., Heinzmann, A., Traherne, J. A., Bhattacharyya, S., Leaves, N. I., Anderson, G. G., Zhang, Y., Lench, N., Carey, A. H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/316944 · Cited by 328 · see citing works
Recombination initiation maps of individual human genomes
Pratto, F., Brick, K., Khil, P., Smagulova, F., Petukhova, G. V., & Camerini-Otero, R. D. (2014) · Science · doi:10.1126/science.1256442 · Cited by 295 · see citing works
Avise, J. C., Lansman, R. A., & Shade, R. O. (1979) · Genetics · doi:10.1093/genetics/92.1.279 · Cited by 281 · see citing works
Why Do Some Tropical Forests Have So Many Species of Trees?
Leigh, E. G., Davidar, P., Dick, C. W., John, T., Puyravaud, J., ter Steege, H., & Wright, S. J. (2004) · Biotropica · doi:10.1646/1607 · Cited by 288 · see citing works
Mapping of mitochondrial DNA of individual sheep and goats: Rapid evolution in the D loop region
Upholt, W. B., & Dawid, I. B. (1977) · Cell · doi:10.1016/0092-8674(77)90075-7 · Cited by 247 · see citing works
Gene Losses during Human Origins
Wang, X., Grus, W. E., & Zhang, J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040052 · Cited by 246 · see citing works
The age of a mutation in a general coalescent tree
Griffiths, R., & Tavaré, S. (1998) · Stochastic Models · doi:10.1080/15326349808807471 · Cited by 242 · see citing works
Inference from Gene Trees in a Subdivided Population
Bahlo, M., & Griffiths, R. (2000) · Theoretical Population Biology · doi:10.1006/tpbi.1999.1447 · Cited by 231 · see citing works
Slatkin, M., & Rannala, B. H. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.225 · Cited by 231 · see citing works
Mutations in KLHL40 Are a Frequent Cause of Severe Autosomal-Recessive Nemaline Myopathy
Ravenscroft, G., Miyatake, S., Lehtokari, V., Todd, E. J., Vornanen, P., Yau, K. S., Hayashi, Y. K., Miyake, N., Tsurusaki, Y., Doi, H., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.05.004 · Cited by 226 · see citing works
Distinguishing between selective sweeps from standing variation and from a de novo mutation
Peter, B. M., Huerta-Sanchez, E., & Nielsen, R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003011 · Cited by 193 · see citing works
Adaptation and Constraint at Toll-Like Receptors in Primates
Wlasiuk, G., & Nachman, M. W. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq104 · Cited by 176 · see citing works
The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
Rouzine, I. M., Brunet, É., & Wilke, C. O. (2007) · Theoretical Population Biology · doi:10.1016/j.tpb.2007.10.004 · Cited by 175 · see citing works
Demography and the Age of Rare Variants
Mathieson, I., & McVean, G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004528 · Cited by 146 · see citing works
Nakajima, T., Wooding, S., Sakagami, T., Emi, M., Tokunaga, K., Tamiya, G., Ishigami, T., Umemura, S., Munkhbat, B., Jin, F., et al. (2004) · American Journal of Human Genetics · doi:10.1086/420793 · Cited by 140 · see citing works
Estimating the age of rare disease mutations: the example of Triple-A syndrome
Génin, E., Pelet, A., Begeot, F., Lyonnet, S., & Abel, L. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.017962 · Cited by 125 · see citing works
Mosaic genome evolution in a recent and rapid avian radiation
Stryjewski, K. F., & Sorenson, M. D. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0364-7 · Cited by 119 · see citing works
How chromosomal inversions reorient the evolutionary process
Berdan, E. L., Barton, N., Butlin, R. K., Charlesworth, B., Faria, R., Fragata, I., Gilbert, K. J., Jay, P., Kapun, M., Lotterhos, K. E., et al. (2023) · Journal of Evolutionary Biology · doi:10.1111/jeb.14242 · Cited by 126 · see citing works
Llopart, A., Lachaise, D., & Coyne, J. A. (2005) · Genetics · doi:10.1534/genetics.104.033597 · Cited by 122 · see citing works
Dombroski, B. A., Scott, A. F., & Kazazian, H. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6513 · Cited by 119 · see citing works
Dick, C. W., Roubik, D. W., Gruber, K. F., & Bermingham, E. (2004) · Molecular Ecology · doi:10.1111/j.1365-294x.2004.02374.x · Cited by 113 · see citing works
Bergman, C., & Bensasson, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702552104 · Cited by 101 · see citing works
Genetic Structure of the Ancestral Population of Modern Humans
Ziętkiewicz, E., Yotova, V., Jarnik, M., Korab-Laskowska, M., Kidd, K., Modiano, D., Scozzari, R., Stoneking, M., Tishkoff, S., Batzer, M., et al. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006371 · Cited by 101 · see citing works
Chakravarti, A., Phillips, J. A., Mellits, K. H., Buetow, K. H., & SEEBURG, P. H. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6085 · Cited by 100 · see citing works
Dating Rare Mutations from Small Samples with Dense Marker Data
Gandolfo, L. C., Bahlo, M., & Speed, T. P. (2014) · Genetics · doi:10.1534/genetics.114.164616 · Cited by 95 · see citing works
A History of Recurrent Positive Selection at the Toll-Like Receptor 5 in Primates
Wlasiuk, G., Khan, S., Switzer, W. M., & Nachman, M. W. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp018 · Cited by 93 · see citing works
The frequency spectrum of a mutation, and its age, in a general diffusion model
Griffiths, R. (2003) · Theoretical Population Biology · doi:10.1016/s0040-5809(03)00075-3 · Cited by 93 · see citing works
Intron presence–absence polymorphism in Drosophila driven by positive Darwinian selection
Llopart, A., Comeron, J. M., Brunet, F., Lachaise, D., & Long, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122570299 · Cited by 92 · see citing works
Templeton, A. R., Weiss, K. M., Nickerson, D. A., Boerwinkle, E., & Sing, C. F. (2000) · Genetics · doi:10.1093/genetics/156.3.1259 · Cited by 91 · see citing works
Polymorphism in the activity of human crossover hotspots independent of local DNA sequence variation
Neumann, R., & Jeffreys, A. J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl063 · Cited by 90 · see citing works
Integrating the processes in the evolutionary system of domestication
Allaby, R. G. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erp382 · Cited by 89 · see citing works
Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate
Feng, C., Pettersson, M. E., Lamichhaney, S., Rubin, C., Rafati, N., Casini, M., Folkvord, A., & Andersson, L. (2017) · eLife · doi:10.7554/elife.23907 · Cited by 85 · see citing works
Rödelsperger, C., Neher, R. A., Weller, A. M., Eberhardt, G., Witte, H., Mayer, W. E., Dieterich, C., & Sommer, R. J. (2014) · Genetics · doi:10.1534/genetics.113.159855 · Cited by 82 · see citing works
Simulating genealogies of selected alleles in a population of variable size
Slatkin, M. (2001) · Genetics Research · doi:10.1017/s0016672301005183 · Cited by 82 · see citing works
Modes of speciation and the neutral theory of biodiversity
Etienne, R. S., Apol, M. E. F., Olff, H., & Weissing, F. J. (2007) · Oikos · doi:10.1111/j.0030-1299.2007.15438.x · Cited by 81 · see citing works
The age of an allele in a finite population
Maruyama, T. (1974) · Genetics Research · doi:10.1017/s0016672300014750 · Cited by 80 · see citing works
McClure, M. C., Ramey, H. R., Rolf, M. M., McKay, S., Decker, J. E., Chapple, R. H., Kim, J. W., Taxis, T. M., Weaber, R. L., Schnabel, R. D., et al. (2012) · Animal Genetics · doi:10.1111/j.1365-2052.2012.02323.x · Cited by 76 · see citing works
Lines-of-descent and genealogical processes, and their applications in population genetics models
Tavaré, S. (1984) · Advances in Applied Probability · doi:10.1017/s000186780002228x · Cited by 67 · see citing works
An Age-of-Allele Test of Neutrality for Transposable Element Insertions
Blumenstiel, J. P., Chen, X., He, M., & Bergman, C. (2013) · Genetics · doi:10.1534/genetics.113.158147 · Cited by 66 · see citing works
A variant-centric perspective on geographic patterns of human allele frequency variation
Biddanda, A., Rice, D. P., & Novembre, J. (2020) · eLife · doi:10.7554/elife.60107 · Cited by 64 · see citing works
A Method for Detecting Recent Selection in the Human Genome From Allele Age Estimates
Toomajian, C., Ajioka, R. S., Jorde, L. B., Kushner, J. P., & Kreitman, M. (2003) · Genetics · doi:10.1093/genetics/165.1.287 · Cited by 65 · see citing works
Choi, H. K., Zhu, Y., & Mount, D. B. (2010) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32833645e8 · Cited by 65 · see citing works
Conditional Genealogies and the Age of a Neutral Mutant
Wiuf, C., & Donnelly, P. (1999) · Theoretical Population Biology · doi:10.1006/tpbi.1998.1411 · Cited by 65 · see citing works
The Evolution of Isochores: Evidence From SNP Frequency Distributions
Lercher, M. J., Smith, N. G. C., Eyre‐Walker, A., & Hurst, L. D. (2002) · Genetics · doi:10.1093/genetics/162.4.1805 · Cited by 65 · see citing works
Empirical Distributions of FST from Large-Scale Human Polymorphism Data
Elhaik, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049837 · Cited by 57 · see citing works
Jaruzelska, J., Ziętkiewicz, E., Batzer, M. A., Cole, D. E. C., Moisan, J., Scozzari, R., Tavaré, S., & Labuda, D. (1999) · Genetics · doi:10.1093/genetics/152.3.1091 · Cited by 63 · see citing works
Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice
Storz, J. F., Baze, M. M., Waite, J. L., Hoffmann, F. G., Opazo, J. C., & Hayes, J. P. (2007) · Genetics · doi:10.1534/genetics.107.078550 · Cited by 62 · see citing works
Mismatch repair genes founder mutations and cancer susceptibility in Lynch syndrome
Ponti, G., Castellsagué, E., Ruini, C., Percesepe, A., & Tomasi, A. (2014) · Clinical Genetics · doi:10.1111/cge.12529 · Cited by 61 · see citing works
Aldrich, C., Wambebe, C. O., Odama, L. E., Rienzo, A. D., & Ober, C. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00377-4 · Cited by 61 · see citing works
The GenoChip: A New Tool for Genetic Anthropology
Elhaik, E., Greenspan, E., Staats, S., Krahn, T., Tyler‐Smith, C., Xue, Y., Tofanelli, S., Francalacci, P., Cucca, F., Pagani, L., et al. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt066 · Cited by 58 · see citing works
Glémin, S. (2010) · Genetics · doi:10.1534/genetics.110.116368 · Cited by 59 · see citing works
Reversibility and the age of an allele. I. Moran's infinitely many neutral alleles model
Watterson, G. A. (1976) · Theoretical Population Biology · doi:10.1016/0040-5809(76)90018-6 · Cited by 59 · see citing works
Population Genomics of Daphnia pulex
Lynch, M., Gutenkunst, R. N., Ackerman, M. S., Spitze, K., Ye, Z., Maruki, T., & Jia, Z. (2016) · Genetics · doi:10.1534/genetics.116.190611 · Cited by 58 · see citing works
Szöts, H., Riethmüller, G., Weiss, E. H., & Meo, T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1428 · Cited by 58 · see citing works
Lavretsky, P., DaCosta, J. M., Sorenson, M. D., McCracken, K. G., & Peters, J. L. (2019) · Molecular Ecology · doi:10.1111/mec.15091 · Cited by 56 · see citing works
Hünemeier, T., Amorim, C. E. G., de Azevedo, S., Contini, V., Acuña-Alonzo, V., Rothhammer, F., Dugoujon, J., Mazières, S., Barrantes, R., Villarreal-Molina, M. T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038862 · Cited by 55 · see citing works
The ages of mutations in gene trees
Griffiths, R., & Tavaré, S. (1999) · The Annals of Applied Probability · doi:10.1214/aoap/1029962804 · Cited by 55 · see citing works
Genetic approaches in comparative and evolutionary physiology
Storz, J. F., Bridgham, J. T., Kelly, S. A., & Garland, T. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00100.2015 · Cited by 53 · see citing works
Positional Cloning by Linkage Disequilibrium
Maniatis, N., Collins, A. R., Gibson, J., Zhang, W., Tapper, W., & Morton, N. E. (2004) · The American Journal of Human Genetics · doi:10.1086/383589 · Cited by 54 · see citing works
Linkage disequilibrium maps and association mapping
Morton, N. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25032 · Cited by 50 · see citing works
Sequence Variation and Haplotype Structure at the Human HFE Locus
Toomajian, C., & Kreitman, M. (2002) · Genetics · doi:10.1093/genetics/161.4.1609 · Cited by 50 · see citing works
Zhang, W., Collins, A., Gibson, J., Tapper, W. J., Hunt, S., Deloukas, P., Bentley, D. R., & Morton, N. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408251102 · Cited by 49 · see citing works
A NOTE ON THE SPEED OF GENE FREQUENCY CHANGES IN REVERSE DIRECTIONS IN A FINITE POPULATION
Maruyama, T., & Kimura, M. (1974) · Evolution · doi:10.1111/j.1558-5646.1974.tb00736.x · Cited by 49 · see citing works
Self-citationThe age of a rare mutant gene in a large population.
Maruyama, T. (1974) · Europe PMC (PubMed Central) · Cited by 48 · see citing works
The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection
Campos, J. L., & Charlesworth, B. (2019) · Genetics · doi:10.1534/genetics.119.301951 · Cited by 48 · see citing works
Measuring the Rates of Spontaneous Mutation From Deep and Large-Scale Polymorphism Data
Messer, P. W. (2009) · Genetics · doi:10.1534/genetics.109.105692 · Cited by 47 · see citing works
Yoshida, T., Ono, H., Kuchiba, A., Saeki, N., & Sakamoto, H. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01590.x · Cited by 49 · see citing works
González-Pérez, E., Esteban, E., Via, M., Gayà-Vidal, M., Athanasiadis, G., Dugoujon, J., Luna, F., Mesa, M., Fuster, V., Kandil, M., et al. (2010) · American Journal of Physical Anthropology · doi:10.1002/ajpa.21161 · Cited by 47 · see citing works
Fuller, Z. L., Haynes, G. D., Richards, S., & Schaeffer, S. W. (2017) · Molecular Ecology · doi:10.1111/mec.14381 · Cited by 43 · see citing works
Part I: Ancestral Inference in Population Genetics
Tavaré, S. (2004) · Lecture notes in mathematics · doi:10.1007/978-3-540-39874-5_1 · Cited by 43 · see citing works
Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data
Schrodi, S. J., DeBarber, A. E., He, M. M., Ye, Z., Peissig, P. L., Wormer, J. J. V., Haws, R. M., Brilliant, M. H., & Steiner, R. D. (2015) · Human Genetics · doi:10.1007/s00439-015-1551-8 · Cited by 42 · see citing works
How old are quantitative trait loci and how widely do they segregate?
Kemper, K. E., Hayes, B. J., Daetwyler, H. D., & Goddard, M. E. (2015) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12152 · Cited by 41 · see citing works
The first arrival time and mean age of a deleterious mutant gene in a finite population.
Li, W. (1975) · PubMed · Cited by 41 · see citing works
Assaf, Z. J. F., Tilk, S., Park, J., Siegal, M. L., & Petrov, D. A. (2017) · Genome Research · doi:10.1101/gr.219956.116 · Cited by 41 · see citing works
Species ages in neutral biodiversity models
Chisholm, R. A., & O’Dwyer, J. P. (2014) · Theoretical Population Biology · doi:10.1016/j.tpb.2014.02.002 · Cited by 40 · see citing works
Detecting emerging strains of tuberculosis by using spoligotypes
Tanaka, M. M., & Francis, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603130103 · Cited by 40 · see citing works
Estimating the Ages of Selection Signals from Different Epochs in Human History
Nakagome, S., Alkorta‐Aranburu, G., Amato, R., Howie, B., Peter, B. M., Hudson, R. R., & Rienzo, A. D. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv256 · Cited by 38 · see citing works
How Long Does It Take to Fix a Favorable Mutation, and Why Should We Care?
Charlesworth, B. (2020) · The American Naturalist · doi:10.1086/708187 · Cited by 38 · see citing works
Griffiths, R., & Lessard, S. (2005) · Theoretical Population Biology · doi:10.1016/j.tpb.2005.02.004 · Cited by 38 · see citing works
The Pattern of Polymorphism on Human Chromosome 21Preprint
印南, 秀., Padhukasahasram, B., & Nordborg, M. (2003) · Genome Research · doi:10.1101/gr.466303 · Cited by 38 · see citing works
Lachance, J. (2010) · BMC Medical Genomics · doi:10.1186/1755-8794-3-57 · Cited by 37 · see citing works
Linkage disequilibrium between rare mutations
Good, B. H. (2022) · Genetics · doi:10.1093/genetics/iyac004 · Cited by 36 · see citing works
Reversibility and the age of an allele II. Two-allele models, with selection and mutation
Watterson, G. A. (1977) · Theoretical Population Biology · doi:10.1016/0040-5809(77)90041-7 · Cited by 36 · see citing works
Wang, S., Lachance, J., Tishkoff, S. A., Hey, J., & Xing, J. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt160 · Cited by 34 · see citing works
Cruciani, F., Trombetta, B., Labuda, D., Modiano, D., Torroni, A., Costa, R., & Scozzari, R. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.105 · Cited by 33 · see citing works
Life history complementarity and the maintenance of biodiversity
Jops, K., & O’Dwyer, J. P. (2023) · Nature · doi:10.1038/s41586-023-06154-w · Cited by 33 · see citing works
A Bayesian method for jointly estimating allele age and selection intensity
SLATKIN, M. (2008) · Genetics Research · doi:10.1017/s0016672307008944 · Cited by 33 · see citing works
Jenkins, P. A., & Song, Y. S. (2011) · Theoretical Population Biology · doi:10.1016/j.tpb.2011.04.001 · Cited by 32 · see citing works
Allele age and a test for selection on rare alleles
Slatkin, M. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0729 · Cited by 32 · see citing works
- Authors
- Kimura, M., & Ohta, T.
- Affiliations
- National Institute of Genetics (JP)
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-09-01
- Volume
- 75
- Issue
- 1
- Pages
- 199-212
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2144162032
- Cited by
- 241
- References
- 5
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 7 · 2012: 10
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Physical Sciences › Mathematics › Mathematical Physics › Stochastic processes and statistical mechanics
- Keywords
- effective population size, mutation rate, genetic drift, diffusion equation, first arrival time, neutral selection
- MeSH terms
- Analysis of Variance, Gene Frequency, Genetics, Population, Mathematics, Mutation, Polymorphism, Genetic, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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