The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Life and death of circulating cell-free DNA
Open accessAbstract
Tumor-specific, circulating cell-free DNA in liquid biopsies is a promising source of biomarkers for minimally invasive serial monitoring of treatment responses in cancer management. We will review the current understanding of the origin of circulating cell-free DNA and different forms of DNA release (including various types of cell death and active secretion processes) and clearance routes. The dynamics of extracellular DNA in blood during therapy and the role of circulating DNA in pathophysiological processes (tumor-associated inflammation, NETosis, and pre-metastatic niche development) provide insights into the mechanisms that contribute to tumor development and metastases formation. Better knowledge of circulating tumor-specific cell-free DNA could facilitate the development of new therapeutic and diagnostic options for cancer management.
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Cited by
Tumor microenvironment complexity and therapeutic implications at a glance
Baghban, R., Roshangar, L., Jahanban-Esfahlan, R., Seidi, K., Ebrahimi-Kalan, A., Jaymand, M., Kolahian, S., Javaheri, T., & Zare, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0530-4 · Cited by 1,784
“Liquid biopsy, intended to monitor cancer treatment responses has recently been considered to be a promising noninvasive cancer-related test that puts cell-free tumor DNA to use [213, 214].”
BackgroundClinical relevance of blood-based ctDNA analysis: mutation detection and beyond
Keller, L., Belloum, Y., Wikman, H., & Pantel, K. (2021) · British Journal of Cancer · doi:10.1038/s41416-020-01047-5 · Cited by 401
ctDNA as a cancer biomarker: A broad overview
Pessoa, L. S., Heringer, M., & Ferrer, V. P. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103109 · Cited by 298
Han, Y., & Kim, S. Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00906-w · Cited by 201
Krumbholz, M., Eiblwieser, J., Ranft, A., Zierk, J., Schmidkonz, C., Stütz, A. M., Peneder, P., Tomazou, E. M., Agaimy, A., Bäuerle, T., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1324 · Cited by 39
Metadata
- Authors
- Kustanovich, A., Schwartz, R., Peretz, T., & Grinshpun, A.
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2019-04-16
- Volume
- 20
- Issue
- 8
- Pages
- 1057-1067
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2937257353
- Cited by
- 606
- References
- 155
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kustanovich, A., Schwartz, R., Peretz, T., & Grinshpun, A. (2019). Life and death of circulating cell-free DNA. Cancer Biology & Therapy. https://doi.org/10.1080/15384047.2019.1598759
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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