Cited by 2,783Cancer Genomics and DiagnosticsAdvanced biosensing and bioanalysis techniquesCancer Diagnosis and Treatment

Detection and localization of surgically resectable cancers with a multi-analyte blood test

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Cohen, Joshua D., Li, Lu, Wang, Yuxuan, Thoburn, Christopher, Afsari, Bahman, Danilova, Ludmila, Douville, Christopher, Javed, Ammar A. +34 more·2018·Science

Abstract

SEEK and you may find cancer earlier: Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity. Science , this issue p. 926 ; see also p. 866

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  1. [25]Liotta LA Petricoin EF 3rd Clin Adv Hematol Oncol 1 460 462 2003 16258432
  2. [28]World Health Organization Treatment of Tuberculosis: Guidelines World Health Organization 2010 23741786
  3. [29]World Health Organization Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach World Health Organization 2016 27466667

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Authors
Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C. L., Goggins, M. G., Dal Molin, M., Wang, T.-L., Roden, R., Klein, A. P., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H.-L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Lennon, A. M., & Papadopoulos, N.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Johns Hopkins University (US)
  • Johns Hopkins Medicine (US)
  • Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • University of Pittsburgh (US)
  • The University of Melbourne (AU)
  • Walter and Eliza Hall Institute of Medical Research (AU)
  • Mayo Clinic (US)
  • The University of Texas MD Anderson Cancer Center (US)
  • IRCCS Ospedale San Raffaele (IT)
  • Memorial Sloan Kettering Cancer Center (US)
Corresponding author
  • Diaz, Luis A.
  • Tomasetti, Cristian
  • Kinzler, Kenneth W.
  • Vogelstein, Bert
  • Lennon, Anne Marie
  • Papadopoulos, Nickolas
Venue
Science
Published
2018-02-23
Volume
359
Issue
6378
Pages
926-930
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2783674487
Cited by
2,783
References
37
Citations by year
2026: 244 · 2025: 343 · 2024: 300 · 2023: 341 · 2022: 301 · 2021: 377 · 2020: 324 · 2019: 317 · 2018: 232 · 2017: 2
FWCI
96.25
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Funders
  • National Institutes of Health (P50-CA62924, P50-CA102701, CA06973, GM-07309, U01CA152753)
  • Doris Duke Charitable Foundation (2014107)
  • Commonwealth Fund
  • John Templeton Foundation
  • Lustgarten Foundation
  • Virginia and D.K. Ludwig Fund for Cancer Research
  • Billi and Bernie Marcus Foundation
  • Mayo Clinic Clinomics Program, Center for Individualized Medicine
  • Defense Sciences Office, DARPA (N66001-15-C-4041​)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Health Sciences › Medicine › Oncology › Cancer Diagnosis and Treatment
Keywords
early cancer detection, cancer screening, circulating proteins, tumor localization, ovarian cancer, liver cancer, gastric cancer, pancreatic cancer, esophageal cancer, colorectal cancer, lung cancer, breast cancer, sensitivity and specificity
MeSH terms
Circulating Tumor DNA, Costs and Cost Analysis, Hematologic Tests, Humans, Mutation, Neoplasm Proteins, Neoplasms, Polymerase Chain Reaction, Early Detection of Cancer

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