The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses
Open accessAbstract
The p53 tumor suppressor is a multifaceted polypeptide that impedes tumorigenesis by regulating a diverse array of cellular processes. Triggered by a wide variety of stress stimuli, p53 transcriptionally regulates genes involved in the canonical tumor suppression pathways of apoptosis, cell-cycle arrest, and senescence. We recently discovered a novel mechanism whereby p53 inhibits cystine uptake through repression of the SLC7A11 gene to mediate ferroptosis. Importantly, this p53-SLC7A11 axis is preserved in the p53(3KR) mutant, and contributes to its ability to suppress tumorigenesis in the absence of the classical tumor suppression mechanisms. Here, we report that wild type p53 can induce both apoptosis and ferroptosis upon reactive oxygen species (ROS)-induced stress. Furthermore, we demonstrate that p53's functional N-terminal domain is required for its capacity to regulate oxidative stress responses and ferroptosis. Notably, activated p53 dynamically modulates intracellular ROS, causing an initial reduction and a subsequent increase of ROS levels. Taken together, these data implicate ferroptosis as an additional component of the cell death program induced by wild type p53 in human cancer cells, and reveal a complex and dynamic role of p53 in oxidative stress responses.
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Cites
p53 Mutations in Human Cancers
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
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Ferroptosis as a p53-mediated activity during tumour suppression
Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398
Self-citationBlinded by the Light: The Growing Complexity of p53
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Transcriptional control of human p53-regulated genes
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Cited by
Ferroptosis: past, present and future
Li, J., Cao, F., Yin, H.-L., Huang, Z.-J., Lin, Z.-T., Mao, N., Sun, B., & Wang, G. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2298-2 · Cited by 4,171
Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy
Latunde-Dada, G. O. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.05.019 · Cited by 892
Reactive oxygen species and cancer paradox: To promote or to suppress?
Galadari, S., Rahman, A., Pallichankandy, S., & Thayyullathil, F. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.004 · Cited by 893
Zhou, N., & Bao, J. (2020) · Database · doi:10.1093/database/baaa021 · Cited by 788
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
Yu, H., Guo, P., Xie, X., Wang, Y., & Chen, G. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13008 · Cited by 710
Metadata
- Authors
- Jiang, L., Hickman, J. H., Wang, S.-J., & Gu, W.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2015-09-17
- Volume
- 14
- Issue
- 18
- Pages
- 2881-2885
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1943418449
- Cited by
- 231
- References
- 8
- Type
- journal article
- Language
- en
- Open access
- bronze
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