Transcriptional control of human p53-regulated genes

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Surfing the p53 network

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Profile hidden Markov models

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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Maximum Entropy Modeling of Short Sequence Motifs with Applications to RNA Splicing Signals

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Definition of a consensus binding site for p53

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The p53 pathway: positive and negative feedback loops

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Hidden Markov Models in Computational Biology

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DNA binding sites: representation and discovery

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Biological sequence analysis

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Assessing computational tools for the discovery of transcription factor binding sites

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A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

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Is a p53-Regulated Inhibitor of G2/M Progression

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The coordinate regulation of the p53 and mTOR pathways in cells

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Applied bioinformatics for the identification of regulatory elements

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p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

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A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome

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DNA sequence-dependent deformability deduced from protein–DNA crystal complexes

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Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

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Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

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Regulation of PTEN Transcription by p53

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

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Induction of the growth inhibitor IGF-binding protein 3 by p53

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Regulation of p53 activity through lysine methylation

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

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A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

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Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

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The ubiquitin ligase COP1 is a critical negative regulator of p53

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The Regulation of Exosome Secretion: a Novel Function of the p53 Protein

Yu, X., Harris, S. L., & Levine, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4579 · Cited by 688 · see citing works

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcriptionPreprint

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The P53 pathway: what questions remain to be explored?

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The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

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Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint

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Synergistic activation of transcription by CBP and p53

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Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

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Wild-type p53 binds to the TATA-binding protein and represses transcription.

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REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3aPreprint

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p53 regulates maternal reproduction through LIF

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Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

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p53 Transcriptional Activation Mediated by Coactivators TAF II 40 and TAF II 60

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BID regulation by p53 contributes to chemosensitivity

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

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Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

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Specificity, free energy and information content in protein–DNA interactions

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Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

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Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

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Inhibition of Cyclooxygenase-2 Gene Expression by p53

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p53DINP1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis

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The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

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Activation of the p53 tumor suppressor protein

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PML Is a Direct p53 Target that Modulates p53 Effector Functions

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The p53MH algorithm and its application in detecting p53-responsive genes

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Regulation of the Human hsp70 Promoter by p53

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p53 Regulates the Expression of the Tumor Suppressor Gene Maspin

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A functional p53-responsive intronic promoter is contained within the human<i>mdm2</i>gene

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A polymorphic microsatellite that mediates induction of PIG3 by p53

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Transcriptional Activation by p53 of the Human Type IV Collagenase (Gelatinase A or Matrix Metalloproteinase 2) Promoter

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PTGF-β , a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway

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Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor

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PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

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ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway

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p53 alterations in human cancer: more questions than answers

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Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

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p21/CDKN1A Mediates Negative Regulation of Transcription by p53

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A Biophysical Approach to Transcription Factor Binding Site DiscoveryPreprint

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Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity

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Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.

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Targets and mechanisms for the regulation of translation in malignant transformation

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NDRG1 Is Necessary for p53-dependent Apoptosis

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Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells

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The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

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Comparative Binding of p53 to its Promoter and DNA Recognition Elements

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Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters

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Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

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Modeling dependencies in protein-DNA binding sites

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Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence

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Wild‐type p53 adopts a ‘mutant’‐like conformation when bound to DNA.

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APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.

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p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site

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Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

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Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53

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p53 tagged sites from human genomic DNA

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Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

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p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding

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p53 Binds and Activates the Xeroderma Pigmentosum <i>DDB2</i> Gene in Humans but Not Mice

Tan, T., & Chu, G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3247-3254.2002 · Cited by 167 · see citing works

Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches

Wang, L., Wu, Q. J., Qiu, P., Mirza, A., McGuirk, M., Kirschmeier, P. T., Greene, J. R., Wang, Y., Pickett, C. B., & Liu, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106570200 · Cited by 164 · see citing works

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

Shou, J., Ali‐Osman, F., Multani, A. S., Pathak, S., Fedi, P., & Srivenugopal, K. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205138 · Cited by 164 · see citing works

Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53

Mori, T., Anazawa, Y., Iiizumi, M., Fukuda, S., Nakamura, Y., & Arakawa, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205459 · Cited by 164 · see citing works

DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms

Clair, S. S., Giono, L. E., Varmeh, S., Resnick‐Silverman, L., Liu, W.-J., Padi, A., Dastidar, J., DaCosta, A., Mattia, M., & Manfredi, J. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.002 · Cited by 162 · see citing works

Apoptotic threshold is lowered by p53 transactivation of caspase-6

MacLachlan, T. K., & El‐Deiry, W. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132241599 · Cited by 162 · see citing works

Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element

Johnson, R. A., Ince, T. A., & Scotto, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100121200 · Cited by 158 · see citing works

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

Ohlsson, C., Kley, N., Werner, H., & LeRoith, D. (1998) · Endocrinology · doi:10.1210/endo.139.3.5832 · Cited by 157 · see citing works

Further characterisation of the p53 responsive element – identification of new candidate genes for trans-activation by p53

Bourdon, J., Chambon, V., Lelong, J., Dessen, P., May, P., Debuire, B., & May, E. (1997) · Oncogene · doi:10.1038/sj.onc.1200804 · Cited by 156 · see citing works

p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor

Yun, J., Chae, H., Choy, H. E., Chung, J., Yoo, H., Han, M.-H., & Shin, D. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29677 · Cited by 155 · see citing works

Histone Deacetylase 2 Modulates p53 Transcriptional Activities through Regulation of p53-DNA Binding Activity

Harms, K. L., & Chen, X. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4397 · Cited by 152 · see citing works

Interaction of p53 with Its Consensus DNA-Binding Site

Wang, Y., Schwedes, J. F., Parks, D., Mann, K., & Tegtmeyer, P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2157 · Cited by 149 · see citing works

The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53

Mashimo, T., Watabe, M., Hirota, S., Hosobe, S., Miura, K., Tegtmeyer, P., Rinker-Schaeffer, C. W., & Watabe, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11307 · Cited by 149 · see citing works

Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis

Dohn, M. R., Jiang, J., & Chen, X. (2001) · Oncogene · doi:10.1038/sj.onc.1204816 · Cited by 146 · see citing works

Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

McKinney, K. M., & Prives, C. L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6797-6808.2002 · Cited by 146 · see citing works

Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites

Golubovskaya, V., Kaur, A. S., & Cance, W. G. (2004) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2004.03.002 · Cited by 145 · see citing works

Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53

Kunz, C., Pebler, S., Otte, J., & von der Ahe, D. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.18.3710 · Cited by 144 · see citing works

p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor

Budhram-Mahadeo, V., Morris, P. J., Smith, M. D., Midgley, C. A., Boxer, L. M., & Latchman, D. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15237 · Cited by 144 · see citing works

Negative regulation of Rb expression by the p53 gene product.

Shiio, Y., Yamamoto, T., & Yamaguchi, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5206 · Cited by 136 · see citing works

Upregulation of Major Histocompatibility Complex Class I on Liver Cells by Hepatitis C Virus Core Protein via p53 and TAP1 Impairs Natural Killer Cell Cytotoxicity

Herzer, K., Falk, C. S., Encke, J., Eichhorst, S. T., Ulsenheimer, A., Seliger, B., & Krammer, P. H. (2003) · Journal of Virology · doi:10.1128/jvi.77.15.8299-8309.2003 · Cited by 134 · see citing works

Differential Recognition of Response Elements Determines Target Gene Specificity forp53 and p63

Osada, M., Park, H. L., Nagakawa, Y., Yamashita, K., Fomenkov, A. I., Kim, M. S., Wu, G., Nomoto, S., Trink, B., & Sidransky, D. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6077-6089.2005 · Cited by 134 · see citing works

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

Thornborrow, E. C., Patel, S., Mastropietro, A. E., Schwartzfarb, E. M., & Manfredi, J. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205069 · Cited by 132 · see citing works

p53 oligomerization and DNA looping are linked with transcriptional activation.

Stenger, J. E., Tegtmeyer, P., Mayr, G. A., Reed, M. J., Wang, Y., Wang, P., Hough, P. V. C., & Mastrangelo, I. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06947.x · Cited by 131 · see citing works

Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.

Morris, G. F., Bischoff, J. R., & Mathews, M. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.895 · Cited by 130 · see citing works

The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

Passer, B. J., Nancy-Portebois, V., Amzallag, N., Prieur, S., Cans, C., de Climens, A. R., Fiucci, G., Bouvard, V., Tuynder, M., Susini, L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530298100 · Cited by 130 · see citing works

Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53

Ueda, K., Arakawa, H., & Nakamura, Y. (2003) · Oncogene · doi:10.1038/sj.onc.1206845 · Cited by 126 · see citing works

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

Feng, Z., Jin, S. V., Zupnick, A., Hoh, J., de Stanchina, E., Lowe, S. W., Prives, C. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1209021 · Cited by 120 · see citing works

Identification of Novel p53 Target Genes in Ionizing Radiation Response

Jen, K., & Cheung, V. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1039 · Cited by 119 · see citing works

Comparative Genome Analysis Identifies the Vitamin D Receptor Gene as a Direct Target of p53-Mediated Transcriptional Activation

Maruyama, R., Aoki, F., Toyota, M., Sasaki, Y., Akashi, H., Mita, H., Suzuki, H., Akino, K., Ohe-Toyota, M., Maruyama, Y., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2562 · Cited by 115 · see citing works

Functional Interaction between p53, the TATA-Binding Protein (TBP), and TBP-Associated Factors In Vivo

Farmer, G., Colgan, J. D., Nakatani, Y., Manley, J. L., & Prives, C. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4295 · Cited by 113 · see citing works

Identification of the mismatch repair genes <i>PMS2</i> and <i>MLH1</i> as p53 target genes by using serial analysis of binding elements

Chen, J., & Sadowski, I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407069102 · Cited by 111 · see citing works

CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress

Han, H. J. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.6.1039 · Cited by 105 · see citing works

p53 Regulates Caveolin Gene Transcription, Cell Cholesterol, and Growth by a Novel Mechanism

Bist, A., Fielding, C. J., & Fielding, P. E. (2000) · Biochemistry · doi:10.1021/bi991721h · Cited by 104 · see citing works

The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation

Li, M., Zhou, J.-Y., Ge, Y., Matherly, L. H., & Wu, G. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307149200 · Cited by 103 · see citing works

Profile of gene expression regulated by induced p53: connection to the TGF‐β family

Kannan, K., Amariglio, N., Rechavi, G., & Givol, D. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01291-6 · Cited by 103 · see citing works

p53 and c-Jun Functionally Synergize in the Regulation of the DNA Repair Gene hMSH2 in Response to UV

Scherer, S. J., Maier, S. M., Seifert, M., Hanselmann, R. G., Zang, K. D., Müller‐Hermelink, H. K., Angel, P. E., Welter, C., & Schartl, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006990200 · Cited by 102 · see citing works

Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53

Gupta, S., Radha, V., Furukawa, Y., & Swarup, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100025200 · Cited by 98 · see citing works

MCG10, a Novel p53 Target Gene That Encodes a KH Domain RNA-Binding Protein, Is Capable of Inducing Apoptosis and Cell Cycle Arrest in G2-M

Zhu, J., & Chen, X. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5602-5618.2000 · Cited by 98 · see citing works

p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53

Ori, A., Zauberman, A., Doitsh, G., Paran, N., Oren, M., & Shaul, Y. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.544 · Cited by 97 · see citing works

Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response

Nylander, K., Bourdon, J., Bray, S. E., Gibbs, N. K., Kay, R. A., Hart, I. R., & Hall, P. A. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200001)190:1 · Cited by 96 · see citing works

Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53

Yoon, H., Liyanarachchi, S., Wright, F. A., Davuluri, R. V., Lockman, J. C., de la Chapelle, A., & Pellegata, N. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242597299 · Cited by 94 · see citing works

p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor

Jung, M.-S., Yun, J., Chae, H., Kim, J., Kim, S., Choi, T.-S., & Shin, D. Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204748 · Cited by 93 · see citing works

p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding.

Peterson, E. J., Bögler, O., & Taylor, S. M. (2003) · PubMed · Cited by 93 · see citing works

p73 is transcriptionally regulated by DNA damage, p53, and p73

Chen, X., Zheng, Y., Zhu, J., Jiang, J., & Wang, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204149 · Cited by 92 · see citing works

Decoy Receptor 2 ( DcR2 ) Is a p53 Target Gene and Regulates Chemosensitivity

Liu, X., Yue, P., Khuri, F. R., & Sun, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0939 · Cited by 92 · see citing works

Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells

Obad, S., Brunnström, H., Vallon-Christersson, J., Borg, Å., Drott, K., & Gullberg, U. (2004) · Oncogene · doi:10.1038/sj.onc.1207524 · Cited by 90 · see citing works

p53 is a NF‐Y‐ and p21‐independent, Sp1‐dependent repressor of cyclin B1 transcription

Innocente, S. A., & Lee, J. M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.12.073 · Cited by 87 · see citing works

Positive and negative regulation of ΔN-p63 promoter activity by p53 and ΔN-p63-α contributes to differential regulation of p53 target genes

Harmes, D. C., Bresnick, E., Lubin, E. A., Watson, J. K., Heim, K. E., Curtin, J. C., Suskind, A. M., Lamb, J., & DiRenzo, J. (2003) · Oncogene · doi:10.1038/sj.onc.1207129 · Cited by 85 · see citing works

A Genomic Map of p53 Binding Sites Identifies Novel p53 Targets Involved in an Apoptotic Network

Miled, C., Pontoglio, M., Garbay, S., Yaniv, M., & Weitzman, J. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4232 · Cited by 85 · see citing works

The Tumor Suppressor Protein p53 Requires a Cofactor to Activate Transcriptionally the Human BAX Promoter

Thornborrow, E. C., & Manfredi, J. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011643200 · Cited by 85 · see citing works

Cloning of P2XM, a novel human P2X receptor gene regulated by p53.

Urano, T., Nishimori, H., Han, H., Furuhata, T., Kimura, Y., Nakamura, Y., & Tokino, T. (1997) · PubMed · Cited by 83 · see citing works

Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53

Zhang, C., Gao, C., Kawauchi, J., Hashimoto, Y., Tsuchida, N., & Kitajima, S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02382-3 · Cited by 80 · see citing works

p53 Stimulates Transcription from the Human Transforming Growth Factor α Promoter: a Potential Growth-Stimulatory Role for p53

Shin, T. H., Paterson, A. J., & Kudlow, J. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4694 · Cited by 78 · see citing works

RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest

Saigusa, K., Imoto, I., Tanikawa, C., Aoyagi, M., Ohno, K., Nakamura, Y., & Inazawa, J. (2006) · Oncogene · doi:10.1038/sj.onc.1210148 · Cited by 77 · see citing works

Endogenous Endothelial Cell Nitric-oxide Synthase Modulates Apoptosis in Cultured Breast Cancer Cells and Is Transcriptionally Regulated by p53

Mortensen, K., Skouv, J., HOUGAARD, D. M., & Larsson, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37679 · Cited by 77 · see citing works

BLIMP1 regulates cell growth through repression of p53 transcription

Yan, J., Jiang, J., Lim, C. A., Wu, Q., Ng, H., & Chin, K.-C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605562104 · Cited by 75 · see citing works

DNA Damage Promotes Histone Deacetylase 4 Nuclear Localization and Repression of G2/M Promoters, via p53 C-terminal Lysines

Basile, V., Mantovani, R., & Imbriano, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507712200 · Cited by 75 · see citing works

Proteomics for the early detection and treatment of hepatocellular carcinoma

Feng, J.-T., Shang, S., & Beretta, L. (2006) · Oncogene · doi:10.1038/sj.onc.1209551 · Cited by 74 · see citing works

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

Farmer, G. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4281 · Cited by 74 · see citing works

The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene

Duriez, C., Falette, N., Audoynaud, C., Moyret-Lalle, C., Bensaad, K., Courtois, S., Wang, Q., Soussi, T., & Puisieux, A. (2002) · Gene · doi:10.1016/s0378-1119(01)00825-3 · Cited by 73 · see citing works

Identification of SCN3B as a novel p53-inducible proapoptotic gene

Adachi, K., Toyota, M., Sasaki, Y., Yamashita, T., Ishida, S., Ohe-Toyota, M., Maruyama, R., Hinoda, Y., Saito, T., Imai, K., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208067 · Cited by 72 · see citing works

A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1

Rozenfeld-Granot, G., Krishnamurthy, J., Kannan, K., Toren, A., Amariglio, N., Givol, D., & Rechavi, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205218 · Cited by 72 · see citing works

<i>p53CSV</i>, a Novel p53-Inducible Gene Involved in the p53-Dependent Cell-Survival Pathway

Park, W.-R., & Nakamura, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3339 · Cited by 72 · see citing works

Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: importance for the regulation of genes involved in cell-cycle arrest and apoptosis

Koutsodontis, G., Vasilaki, E., Chou, W., Papakosta, P., & Kardassis, D. (2005) · Biochemical Journal · doi:10.1042/bj20041980 · Cited by 70 · see citing works

p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers

Zhang, D. W., Jeang, K.-T., & Lee, C. G. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209220 · Cited by 69 · see citing works

Transcriptional activation of the human S100A2 promoter by wild‐type p53

Tan, M., Heizmann, C. W., Guan, K., Schäfer, B. W., & Sun, Y. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00135-0 · Cited by 69 · see citing works

Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadasivam, S., Gupta, S., Radha, V., Batta, K., Kundu, T. K., & Swarup, G. (2004) · Oncogene · doi:10.1038/sj.onc.1208201 · Cited by 63 · see citing works

p53 and Apoptosis: It's Not Just in the Nucleus Anymore

Manfredi, J. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00106-0 · Cited by 63 · see citing works

Transcriptional Regulation of Mitotic Checkpoint Gene MAD1 by p53

Chun, A. C. S., & Jin, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307185200 · Cited by 60 · see citing works

Identification of fractalkine, a CX3C-type chemokine, as a direct target of p53.

Shiraishi, K., Fukuda, S., Mori, T., Matsuda, K., Yamaguchi, T., Tanikawa, C., Ogawa, M., Nakamura, Y., & Arakawa, H. (2000) · PubMed · Cited by 59 · see citing works

Identification of a p53 Response Element in the Promoter Region of the hMSH2 Gene Required for Expression in A2780 Ovarian Cancer Cells

Warnick, C. T., Dabbas, B., Ford, C. D., & Strait, K. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103088200 · Cited by 59 · see citing works

Divergent Regulation of the Growth-promoting GeneIEX-1 by the p53 Tumor Suppressor and Sp1

Im, H., Pittelkow, M. R., & Kumar, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109414200 · Cited by 58 · see citing works

Dynamics of the p53 Acetylation Pathway

Gu, W., Luo, J., Brooks, C. L., Nikolaev, A. Y., & Li, M. (2004) · Novartis Foundation symposium · doi:10.1002/0470862637.ch14 · Cited by 57 · see citing works

p53 down‐regulates matrix metalloproteinase‐1 by targeting the communications between AP‐1 and the basal transcription complex

Sun, Y., Zeng, X., Wenger, L., Firestein, G. S., & Cheung, H. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20044 · Cited by 57 · see citing works

Chromatin Immunoprecipitation-Based Screen To Identify Functional Genomic Binding Sites for Sequence-Specific Transactivators

Hearnes, J. M., Mays, D. J., Schavolt, K. L., Tang, L., Jiang, X. J., & Pietenpol, J. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10148-10158.2005 · Cited by 57 · see citing works

AMID is a p53-inducible gene downregulated in tumors

Wu, M., Xu, L., Su, T., Tian, Y., Zhai, Z., & Shu, H. (2004) · Oncogene · doi:10.1038/sj.onc.1207909 · Cited by 56 · see citing works

Repression of hsp90β Gene by p53 in UV Irradiation-induced Apoptosis of Jurkat Cells

Zhang, Y., Wang, J., Chen, L., Zhang, Y., Cheng, X.-K., Heng, F.-Y., Wu, N., & Shen, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314213200 · Cited by 56 · see citing works

The second intron of the human galectin‐3 gene has a strong promoter activity down‐regulated by p53

Raimond, J., Rouleux‐Bonnin, F., Monsigny, M. L. P., & Legrand, A. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00310-6 · Cited by 55 · see citing works

p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1

Ng, C.-C., Arakawa, H., Fukuda, S., Kondoh, H., & Nakamura, Y. (2003) · Oncogene · doi:10.1038/sj.onc.1206586 · Cited by 54 · see citing works

Translational control of gene expression: Role of IRESs and consequences for cell transformation and angiogenesis

Prats, A., & Prats, H. (2002) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(02)72075-8 · Cited by 53 · see citing works

Additive effect between NF-κB subunits and p53 protein for transcriptional activation of human p53 promoter

Benoît, V., Hellin, A., Huygen, S., GIELEN, J. E., Bours, V., & Merville, M.-P. (2000) · Oncogene · doi:10.1038/sj.onc.1203831 · Cited by 52 · see citing works

Regulation of the c-met Proto-oncogene Promoter by p53

Seol, D., Chen, Q., Smith, M. L., & Zarnegar, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3565 · Cited by 51 · see citing works

BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma

Margalit, O., Amram, H. W., Amariglio, N., Simon, A. J., Shaklai, S., Granot, G., Minsky, N., Shimoni, A., Harmelin, A., Givol, D., et al. (2005) · Blood · doi:10.1182/blood-2005-04-1629 · Cited by 51 · see citing works

p53 Represses CAAT Enhancer-binding Protein (C/EBP)-dependent Transcription of the Albumin Gene

Kubicka, S., Kühnel, F., Zender, L., Rudolph, K. L., Plümpe, J., Manns, M. P., & Trautwein, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32137 · Cited by 50 · see citing works

Upregulation of the Elongation Factor-1α Gene by p53 in Association With Death of an Erythroleukemic Cell Line

Kato, M. V., Sato, H., Nagayoshi, M., & Ikawa, Y. (1997) · Blood · doi:10.1182/blood.v90.4.1373 · Cited by 50 · see citing works

IL-6 Rescues Enterocytes from Hemorrhage Induced Apoptosisin Vivoandin Vitroby abcl-2Mediated Mechanism

Rollwagen, F. M., Yu, Z.-Y., Li, Y., & Pacheco, N. D. (1998) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1998.4600 · Cited by 49 · see citing works

p53-dependent Transcriptional Regulation of theAPC Promoter in Colon Cancer Cells Treated with DNA Alkylating Agents

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