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BECN1 is a new driver of ferroptosis
Open accessAbstract
Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferroptosis through the regulation of activity of the cysteine and glutamate antiporter system xc− in cancer cells. BECN1-dependent autophagy requires the formation of the BECN1-containing class III phosphatidylinositol 3-kinase (PtdIns3K) complex, whereas BECN1-dependent ferroptosis requires the formation of a BECN1-SLC7A11 complex. Furthermore, AMP-activated protein kinase (AMPK) is required for BECN1 phosphorylation to trigger formation of the BECN1-SLC7A11 complex in the process of inhibiting system xc− activity and inducing lipid peroxidation. These findings suggest that the autophagy-dependent and -independent functions of BECN1 play distinct roles in regulated cell death.
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationGPX4 in cell death, autophagy, and disease
Xie, Y., Kang, R., Klionsky, D. J., & Tang, D. (2023) · Autophagy · doi:10.1080/15548627.2023.2218764 · Cited by 623
Self-citationDai, E., Han, L., Liu, J., Xie, Y., Kroemer, G., Klionsky, D. J., Zeh, H. J., Kang, R., Wang, J., & Tang, D. (2020) · Autophagy · doi:10.1080/15548627.2020.1714209 · Cited by 613
Self-citationLipid storage and lipophagy regulates ferroptosis
Bai, Y., Meng, L., Han, L., Jia, Y., Zhao, Y., Gao, H., Kang, R., Wang, X., Tang, D., & Dai, E. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.039 · Cited by 507
Self-citationZhang, Z., Guo, M., Li, Y., Shen, M., Kong, D., Shao, J., Ding, H., Tan, S., Chen, A., Zhang, F., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1687985 · Cited by 462
Metadata
- Authors
- Kang, R., Zhu, S., Zeh, H. J., Klionsky, D. J., & Tang, D.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2018-09-06
- Volume
- 14
- Issue
- 12
- Pages
- 2173-2175
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2889336787
- Cited by
- 189
- References
- 0
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kang, R., Zhu, S., Zeh, H. J., Klionsky, D. J., & Tang, D. (2018). BECN1 is a new driver of ferroptosis. Autophagy. https://doi.org/10.1080/15548627.2018.1513758
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