Cited by 133Muscle Physiology and DisordersCancer-related gene regulationMuscle metabolism and nutrition

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Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis

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Choi, Seri, Jeong, Hyeon-Ju, Kim, Hyebeen, Choi, Dahee, Cho, Sung-Chun, Seong, Je Kyung, Koo, Seung-Hoi, Kang, Jong-Sun·2019·Autophagy

DOI 10.1080/15548627.2019.1569931PMC PMC6526864

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Abstract

Protein arginine methyltransferases (PRMTs) have emerged as important regulators of skeletal muscle metabolism and regeneration. However, the direct roles of the various PRMTs during skeletal muscle remodeling remain unclear. Using skeletal muscle-specific prmt1 knockout mice, we examined the function and downstream targets of PRMT1 in muscle homeostasis. We found that muscle-specific PRMT1 deficiency led to muscle atrophy. PRMT1-deficient muscles exhibited enhanced expression of a macroautophagic/autophagic marker LC3-II, FOXO3 and muscle-specific ubiquitin ligases, TRIM63/MURF-1 and FBXO32, likely contributing to muscle atrophy. The mechanistic study reveals that PRMT1 regulates FOXO3 through PRMT6 modulation. In the absence of PRMT1, increased PRMT6 specifically methylates FOXO3 at arginine 188 and 249, leading to its activation. Finally, we demonstrate that PRMT1 deficiency triggers FOXO3 hyperactivation, which is abrogated by PRMT6 depletion. Taken together, PRMT1 is a key regulator for the PRMT6-FOXO3 axis in the control of autophagy and protein degradation underlying muscle maintenance.Abbreviations: Ad-RNAi: adenovirus-delivered small interfering RNA; AKT: thymoma viral proto-oncogene; AMPK: AMP-activated protein kinase; Baf A1: bafilomycin A1; CSA: cross-sectional area; EDL: extensor digitorum longus; FBXO32: F-box protein 32; FOXO: forkhead box O; GAS: gatrocnemieus; HDAC: histone deacetylase; IGF: insulin-like growth factor; LAMP: lysosomal-associated membrane protein; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; mKO: Mice with skeletal muscle-specific deletion of Prmt1; MTOR: mechanistic target of rapamycin kinase; MYH: myosin heavy chain; MYL1/MLC1f: myosin, light polypeptide 1; PRMT: protein arginine N-methyltransferase; sgRNA: single guide RNA; SQSTM1: sequestosome 1; SOL: soleus; TA: tibialis anterior; TRIM63/MURF-1: tripartite motif-containing 63; YY1: YY1 transcription factor

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Authors: Choi, S., Jeong, H.-J., Kim, H., Choi, D., Cho, S.-C., Seong, J. K., Koo, S.-H., & Kang, J.-S.
Affiliations: Korea University (KR)
Sungkyunkwan University (KR)
Samsung (South Korea) (KR)
Seoul National University (KR)
Corresponding author: Koo, Seung-Hoi
Kang, Jong-Sun
ORCID: Choi, Seri
Jeong, Hyeon-Ju
Kim, Hyebeen
Choi, Dahee
Seong, Je Kyung
Koo, Seung-Hoi
Venue: Autophagy
Publisher: Informa UK Limited
Published: 2019-02-05
Volume: 15
Issue: 6
Pages: 1069-1081
ISSN: 1554-8627 (ISSN-L)
1554-8635
DOI: 10.1080/15548627.2019.1569931
PMC: PMC6526864
OpenAlex: W2908751660
Cited by: 132
References: 61
Citations by year: 2026: 13 · 2025: 16 · 2024: 23 · 2023: 25 · 2022: 24 · 2021: 14 · 2020: 10 · 2019: 7
FWCI: 4.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Autophagy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: National Research Foundation of Korea (NRF-2016R1A2B2007179)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: PRMT1, PRMT6, FOXO3, skeletal muscle atrophy, protein arginine methyltransferase, ubiquitin ligase, atrogin-1, protein degradation, muscle homeostasis, arginine methylation, LC3-II, muscle regeneration, muscle metabolism
MeSH terms: Tripartite Motif Proteins, Forkhead Box Protein O3, Proto-Oncogene Mas, Histone Deacetylase 3, Animals, Autophagy, Histone Deacetylases, Humans, Methylation, Microtubule-Associated Proteins, Muscle Proteins, Muscular Atrophy, Phosphorylation, Protein-Arginine N-Methyltransferases, Signal Transduction, Mice, Knockout, Muscle, Skeletal, Ubiquitin-Protein Ligases, YY1 Transcription Factor, Mice, Histone Deacetylase 2, HEK293 Cells

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Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis

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