How do the pharmacokinetics of drugs change in astronauts in space?
Open accessAbstract
By the beginning of 2020, over 560 individuals have flown in space, with duration ranging from 15 min to 437 days. Among these were seven ‘space tourists’, some with known medical problems, who typ...
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This phenomenon could alter the pharmacokinetics and pharmacodynamics of antioxidants by changing absorptivity.
“As a result, this phenomenon could alter the pharmacokinetics and pharmacodynamics of antioxidants by changing absorptivity108.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [108]
Section 3 says microgravity may change drug pharmacokinetics through effects on absorption. It does not address antioxidants specifically or establish that altered absorption changes their pharmacodynamics. The indexed passages provide no page numbers. (LLM, conf=0.84)
Experimental — accuracy not yet measuredHLU models are affordable and viable alternatives to explore the differences in pharmacokinetics and pharmacodynamics.
“The HLU models are affordable and viable alternatives to explore the differences in pharmacokinetics and pharmacodynamics.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [108]
Section 3 (page unavailable) says terrestrial bed-rest and rodent analog models have been used to study spaceflight effects on drug disposition, supporting the general idea of models for pharmacokinetic research. It does not identify HLU models, describe them as affordable, or say they are used to explore pharmacodynamic differences; it also cautions that analog models do not capture many features of spaceflight. (LLM, conf=0.84)
Experimental — accuracy not yet measuredFew studies have been conducted taking into account the pharmacokinetics and pharmacodynamics of both antioxidants and other drugs.
“Currently, few studies have been conducted taking into account the pharmacokinetics and pharmacodynamics of both antioxidants and other drugs.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [108]
Section 3 (page not provided) says evidence on drug pharmacokinetics during spaceflight is limited and essential pharmacodynamic data are scarce. Section 5 likewise describes scarce data on drug disposition in astronauts. The paper does not establish the claim specifically for antioxidants, or for drugs outside the spaceflight setting. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe studies that have taken into account pharmacokinetics and pharmacodynamics of antioxidants and other drugs had a small sample size and did not have a consistent methodology.
“Furthermore, the studies that have done so had a small sample size and did not have a consistent methodology108.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [108]
Section 3 (page unavailable) says the astronaut drug-pharmacokinetic studies had small subject numbers and varied in sampling time, administration route, formulation, and other methods. It does not establish the same limitation for studies of antioxidants or pharmacodynamics, which the claim also includes. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMany spaceflight conditions cannot be replicated and some changes in space may not be consistent with Earth models.
“However, many spaceflight conditions cannot be replicated and some changes in space may not be consistent with Earth models108.”
There is no evidence about pharmacogenetics in space.
“Unfortunately, there is no evidence about pharmacogenetics in space108.”
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Cites
Venous Thrombosis during Spaceflight
Auñón-Chancellor, S. M., Pattarini, J. M., Moll, S., & Sargsyan, A. (2020) · New England Journal of Medicine · doi:10.1056/nejmc1905875 · Cited by 179 · see citing works
Flagged first, then by citations
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- Zhang Y, Lu T, Wong M, et al. Transient gene and microRNA expression profile changes of confluent human fibroblast cells in spaceflight. Faseb J. 2016 Jun;30(6):2211-2224.
- Stingl JC, Welker S, Hartmann G, et al. Where failure is not an option -personalized medicine in astronauts. PloS One. 2015;10 (10):e0140764. • An analysis of potential sources for pharmacogenetic variabil- ity with regard to drugs available onbord the ISS.
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Cited by
Sorted by citations
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92 · see citing works
- Authors
- Eyal, S.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Eyal, Sara
- ORCID
- Eyal, Sara
- Venue
- Expert Opinion on Drug Metabolism & Toxicology
- Publisher
- Informa UK Limited
- Published
- 2020-03-29
- Volume
- 16
- Issue
- 5
- Pages
- 353-356
- ISSN
- 1742-5255 (ISSN-L)
- 1744-7607
- OpenAlex
- W3013432597
- Cited by
- 33
- References
- 1
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 10 · 2021: 4 · 2020: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Opinion on Drug Metabolism & Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Space exploration and regulation
- Keywords
- pharmacokinetics, astronauts, spaceflight, drug metabolism, microgravity, long-duration spaceflight
- MeSH terms
- Animals, Pharmaceutical Preparations, Humans, Pharmacokinetics, Space Flight, Astronauts
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