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Nano-silver – a review of available data and knowledge gaps in human and environmental risk assessment
Abstract
Nano-silver is used in an increasing number of products. Some of the applications have resulted in the concern of governments and the public, since little is known about the potential risks of nano-silver. In this review, an inventory is made to identify knowledge gaps that have to be filled before risks for both man and the environment can be assessed as reliable as for ‘non-nanosized’ chemicals. It is hypothesized that the toxic effects of nano-silver are due to a combination of the specific properties of silver nanoparticles and the generation of ions from them. The main topic for future research is validation of our ‘0-hypothesis’ that toxic effects of nano-silver are proportional to the activity of free silver ions released by the nanoparticles. Furthermore, it must be determined whether – or to what extent – nano-silver particles will enter the body. The outcomes of these tests will determine the requirements for further toxicity testing.
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Citations
Cited by
Schirinzi, G. F., Pérez-Pomeda, I., Sanchís, J., Rossini, C., Farré, M., & Barceló, D. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.043 · Cited by 902
Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps
Bergin, I. L., & Witzmann, F. A. (2013) · International Journal of Biomedical Nanoscience and Nanotechnology · doi:10.1504/ijbnn.2013.054515 · Cited by 412
Nanoparticles skin absorption: New aspects for a safety profile evaluation
Larese Filon, F., Mauro, M., Adami, G., Bovenzi, M., & Crosera, M. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.05.005 · Cited by 390
Greulich, C., Braun, D., Peetsch, A., Diendorf, J., Siebers, B., Epple, M., & Köller, M. (2012) · RSC Advances · doi:10.1039/c2ra20684f · Cited by 389
Shape matters: effects of silver nanospheres and wires on human alveolar epithelial cells
Stoehr, L. C., Gonzalez, E., Stampfl, A., Casals, E., Duschl, A., Puntes, V., & Oostingh, G. J. (2011) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-8-36 · Cited by 266
Metadata
- Authors
- Wijnhoven, S. W. P., Peijnenburg, W. J. G. M., Herberts, C. A., Hagens, W. I., Oomen, A. G., Heugens, E. H. W., Roszek, B., Bisschops, J., Gosens, I., Van De Meent, D., Dekkers, S., De Jong, W. H., van Zijverden, M., Sips, A. J. A. M., & Geertsma, R. E.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 3
- Issue
- 2
- Pages
- 109-138
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W1970411171
- Cited by
- 1,321
- References
- 0
- FWCI
- 29.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wijnhoven, S. W. P., Peijnenburg, W. J. G. M., Herberts, C. A., Hagens, W. I., Oomen, A. G., Heugens, E. H. W., Roszek, B., Bisschops, J., Gosens, I., Van De Meent, D., Dekkers, S., De Jong, W. H., van Zijverden, M., Sips, A. J. A. M., & Geertsma, R. E. (2009). Nano-silver – a review of available data and knowledge gaps in human and environmental risk assessment. Nanotoxicology. https://doi.org/10.1080/17435390902725914
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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