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Nanonization techniques to overcome poor water-solubility with drugs

Da Silva, Flávia Lidiane Oliveira, Marques, Maria Betânia De Freitas, Kato, Kelly Cristina, Carneiro, Guilherme·2020·Expert Opinion on Drug Discovery
DOI 10.1080/17460441.2020.1750591
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Abstract

Introduction Most drugs used in therapy have low water-solubility, a factor that could reduce their dissolution rate and oral bioavailability, representing a challenge in pharmaceutical development. Nanonization of drugs is the reduction of particles to nanoscale, increasing the surface area and consequently the saturation solubility and dissolution rate and resulting in higher bioavailability. Areas covered This review provides an overview of the consequences of the poor water-solubility and the main strategies applied to increase the solubility of poorly water-soluble drugs. The relationship between the biopharmaceutical classification system and the solubilization process of the drug is also considered. Finally, it includes how drug nanoparticles and nanocarriers, especially lipid-based nanosystems, can overcome these challenges and which of these approaches are already available on the market. Expert opinion Due to the growing importance of nanomedicines, especially for applications in poorly water-soluble drugs, it is important to clearly establish the specifications and quality criteria for nanonized drugs to ensure the quality and safety of nanoparticles.

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Metadata

Authors
Da Silva, F. L. O., Marques, M. B. D. F., Kato, K. C., & Carneiro, G.
Venue
Expert Opinion on Drug Discovery
Publisher
Informa UK Limited
Published
2020-04-15
Volume
15
Issue
7
Pages
853-864
ISSN
  • 1746-0441
  • 1746-045X
DOI
10.1080/17460441.2020.1750591
Cited by
136
References
4
Language
en
Funders
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil

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