Dietary phytochemicals targeting Nrf2 for chemoprevention in breast cancer

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699 · see citing works

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works

Breast cancer

Harbeck, N., Penault-Llorca, F., Cortes, J., Gnant, M., Houssami, N., Poortmans, P., Ruddy, K., Tsang, J., & Cardoso, F. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0111-2 · Cited by 3,024 · see citing works

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works

Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals

Liu, R. H. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.517s · Cited by 2,186 · see citing works

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

Ambati, R., Phang, S. M., Ravi, S., & Ravishankar, G. A. (2014) · Marine Drugs · doi:10.3390/md12010128 · Cited by 1,993 · see citing works

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., Hayashi, M., Sekine, H., Tanaka, N., Moriguchi, T., Motohashi, H., Nakayama, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms11624 · Cited by 1,878 · see citing works

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607 · see citing works

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102 · see citing works

Kaempferol: A Key Emphasis to Its Anticancer Potential

Imran, M., Salehi, B., Sharifi-Rad, J., Aslam Gondal, T., Saeed, F., Imran, A., Shahbaz, M., Tsouh Fokou, P. V., Umair Arshad, M., Khan, H., et al. (2019) · Molecules · doi:10.3390/molecules24122277 · Cited by 819 · see citing works

Small Molecule Modulators of <scp>K</scp> eap1‐ <scp>N</scp> rf2‐ <scp>ARE</scp> Pathway as Potential Preventive and Therapeutic Agents

Magesh, S., Chen, Y., & Hu, L. (2012) · Medicinal Research Reviews · doi:10.1002/med.21257 · Cited by 760 · see citing works

Adjuvant Endocrine Therapy for Women With Hormone Receptor–Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update

Burstein, H. J., Lacchetti, C., Anderson, H., Buchholz, T. A., Davidson, N. E., Gelmon, K. A., Giordano, S. H., Hudis, C. A., Solky, A. J., Stearns, V., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.18.01160 · Cited by 648 · see citing works

Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

Nguyen, T., Sherratt, P. J., Huang, H.-C., Yang, C. S., & Pickett, C. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207293200 · Cited by 615 · see citing works

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Luo, H., Vong, C. T., Chen, H., Gao, Y., Lyu, P., Qiu, L., Zhao, M., Liu, Q., Cheng, Z., Zou, J., et al. (2019) · Chinese Medicine · doi:10.1186/s13020-019-0270-9 · Cited by 569 · see citing works

Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

Dehelean, C. A., Marcovici, I., Şoica, C., Mioc, M., Coricovac, D. E., Iurciuc, S., Cretu, O. M., & Pînzaru, I. (2021) · Molecules · doi:10.3390/molecules26041109 · Cited by 508 · see citing works

Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism

McMahon, M. J., Thomas, N., Itoh, K., Yamamoto, M. P., & Hayes, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601119200 · Cited by 489 · see citing works

Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism

Tong, K. I., Kobayashi, A., Katsuoka, F., & Yamamoto, M. (2006) · Biological Chemistry · doi:10.1515/bc.2006.164 · Cited by 473 · see citing works

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

Shaw, P., & Chattopadhyay, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29219 · Cited by 431 · see citing works

Oxidative Stress and Cancer: The Role of Nrf2

Sajadimajd, S., & Khazaei, M. (2017) · Current Cancer Drug Targets · doi:10.2174/1568009617666171002144228 · Cited by 424 · see citing works

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

Suzuki, T., & Yamamoto, M. P. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.800169 · Cited by 402 · see citing works

RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Li, Y., Luo, L., Hayes, J. D., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3386 · Cited by 382 · see citing works

The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review

Zhu, B., Zhang, Q., Hua, J.-W., Cheng, W., & Qin, L. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.08.023 · Cited by 333 · see citing works

NRF2 as a regulator of cell metabolism and inflammation in cancer

He, F., Antonucci, L., & Karin, M. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa039 · Cited by 318 · see citing works

Chemosensitization of tumors by resveratrol

Gupta, S. C., Kannappan, R., Reuter, S., Kim, J. H., & Aggarwal, B. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05852.x · Cited by 308 · see citing works

Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms

Sinha, D., Sarkar, N., Biswas, J., & Bishayee, A. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.11.001 · Cited by 262 · see citing works

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Hassanein, E. H. M., Sayed, A. M. M., Hussein, O. E., & Mahmoud, A. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1675957 · Cited by 257 · see citing works

Allyl isothiocyanate as a cancer chemopreventive phytochemical

Zhang, Y. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900323 · Cited by 249 · see citing works

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

Khor, T. O., Huang, Y. S., Wu, T., Shu, L., Lee, J. H., & Kong, A. T. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.065 · Cited by 245 · see citing works

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

Shu, L., Cheung, K., Khor, T. O., Chen, C., & Kong, A. T. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9239-y · Cited by 243 · see citing works

Molecular insight in the multifunctional activities of Withaferin A

Berghe, W. V., Sabbe, L., Kaileh, M., Haegeman, G., & Heyninck, K. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.027 · Cited by 241 · see citing works

Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action

Mense, S. M., Hei, T. K., Ganju, R. K., & Bhat, H. K. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10538 · Cited by 229 · see citing works

Comprehensive Review on Betulin as a Potent Anticancer Agent

Król, S. K., Kiełbus, M., Rivero‐Müller, A., & Stepulak, A. (2015) · BioMed Research International · doi:10.1155/2015/584189 · Cited by 221 · see citing works

Dietary vitamin C in human health

Granger, M., & Eck, P. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.11.006 · Cited by 217 · see citing works

Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?

Suraweera, T. L., Rupasinghe, H. P. V., Dellaire, G., & Xu, Z. (2020) · Antioxidants · doi:10.3390/antiox9100973 · Cited by 207 · see citing works

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Selvakumar, P., Badgeley, A., Murphy, P., Anwar, H., Sharma, U., Lawrence, K., & Lakshmikuttyamma, A. (2020) · Nutrients · doi:10.3390/nu12030761 · Cited by 205 · see citing works

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation

Zhang, C., Su, Z., Khor, T. O., Shu, L., & Kong, A. T. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.010 · Cited by 202 · see citing works

Medication Use to Reduce Risk of Breast Cancer

US Preventive Services Task Force, Owens, D. K., Davidson, K. W., Krist, A. H., Barry, M. J., Cabana, M. D., Caughey, A. B., Doubeni, C. A., Epling, J. W., Kubik, M., et al. (2019) · JAMA · doi:10.1001/jama.2019.11885 · Cited by 187 · see citing works

Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25

Zan, L., Chen, Q., Zhang, L., & Li, X. (2019) · Bioengineered · doi:10.1080/21655979.2019.1657327 · Cited by 184 · see citing works

Nrf2 promotes breast cancer cell migration via up‐regulation of G6PD/HIF‐1α/Notch1 axis

Zhang, H., Zhang, Z., Du, G., Sun, H., Liu, H., Zhou, Z., Gou, X., Wu, X., Yu, X., & Huang, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14241 · Cited by 180 · see citing works

Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis

Kundu, J. K., & Surh, Y. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0096-8 · Cited by 173 · see citing works

Enhancing Curcumin Oral Bioavailability Through Nanoformulations

Ipar, V. S., D’souza, A. A., & Devarajan, P. V. (2019) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-019-00545-z · Cited by 171 · see citing works

Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence

Saini, R. K., Keum, Y., Daglia, M., & Rengasamy, K. R. R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104830 · Cited by 169 · see citing works

Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways

Singh, B., Shoulson, R. L., Chatterjee, A., Ronghe, A. M., Bhat, N. K., Dim, D. C., & Bhat, H. K. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu120 · Cited by 155 · see citing works

Cysteine-based regulation of the CUL3 adaptor protein Keap1

Sekhar, K. R., Rachakonda, G., & Freeman, M. L. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.06.016 · Cited by 153 · see citing works

Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation by Sulforaphane

Su, Z., Zhang, C., Lee, J. H., Shu, L., Wu, T., Khor, T. O., Conney, A. H., Lu, Y.-P., & Kong, A. T. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0313-t · Cited by 143 · see citing works

Nanonization techniques to overcome poor water-solubility with drugs

da Silva, F. L. O., Marques, M. B. D. F., Kato, K. C., & Carneiro, G. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1750591 · Cited by 143 · see citing works

Evaluation of the potential in vivo genotoxicity of quercetin

Utesch, D., Feige, K., Dasenbrock, J., Broschard, T. H., Harwood, M., Danielewska-Nikiel, B., & Lines, T. C. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.04.008 · Cited by 140 · see citing works

Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery

Tang, L., Li, J., Zhao, Q., Pan, T., Zhong, H., & Wang, W. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081151 · Cited by 139 · see citing works

Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia

Syu, J.-P., Chi, J., & Kung, H. (2016) · Oncotarget · doi:10.18632/oncotarget.7406 · Cited by 133 · see citing works

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

Zhang, C., Wang, H.-J., Bao, Q., Wang, L., Guo, T.-K., Chen, W., Xu, L., Zhou, H.-S., Bian, J., Yang, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12435 · Cited by 127 · see citing works

Withania somnifera: From prevention to treatment of cancer

Palliyaguru, D. L., Singh, S. V., & Kensler, T. W. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500756 · Cited by 126 · see citing works

Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer

Singh, B. P., Chatterjee, A., Ronghe, A. M., Bhat, N. K., & Bhat, H. K. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-253 · Cited by 115 · see citing works

Chemopreventive and Chemotherapeutic Potential of Curcumin in Breast Cancer

Sinha, D., Biswas, J., Sung, B., Aggarwal, B. B., & Bishayee, A. (2012) · Current Drug Targets · doi:10.2174/138945012804545632 · Cited by 114 · see citing works

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez‐Félix, F., Del‐Toro‐Sánchez, C. L., Cinco-Moroyoqui, F. J., Juárez, J., Ruíz‐Cruz, S., López‐Ahumada, G. A., Carvajal‐Millán, E., Castro‐Enríquez, D. D., Barreras‐Urbina, C. G., & Tapia‐Hernández, J. A. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14803 · Cited by 114 · see citing works

Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species

Ullah, M. F., Ahmad, A., Zubair, H., Khan, H. Y., Wang, Z. P., Sarkar, F. H., & Hadi, S. M. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000329 · Cited by 113 · see citing works

Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer

Singh, B. P., & Bhat, H. K. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs300 · Cited by 108 · see citing works

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos, C., & Pippa, Ν. (2013) · Drug Delivery · doi:10.3109/10717544.2013.844745 · Cited by 105 · see citing works

Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells

Lee, S., Hallis, S. P., Jung, K.-A., Ryu, D.-Y., & Kwak, M. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101210 · Cited by 105 · see citing works

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

Kaspar, J. W., & Jaiswal, A. K. (2010) · The FASEB Journal · doi:10.1096/fj.10-171553 · Cited by 99 · see citing works

The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019

Xu, S., Liu, Y., Zhang, T., Zheng, J., Lin, W., Cai, J., Zou, J., Chen, Y., Xie, Y., Chen, Y., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.689562 · Cited by 99 · see citing works

Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies

Berretta, M., Quagliariello, V., Maurea, N., Francia, R. D., Sharifi, S., Facchini, G., Rinaldi, L., Piezzo, M., Manuela, C., Nunnari, G., et al. (2020) · Antioxidants · doi:10.3390/antiox9121182 · Cited by 91 · see citing works

Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer

Yao, Y., Brodie, A. M. H., Davidson, N. E., Kensler, T. W., & Zhou, Q. Y. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1023-8 · Cited by 89 · see citing works

Conference Scene: From Innovative Polymers to Advanced Nanomedicine: Key Challenges, Recent Progress and Future Perspectives

Feijén, J., Hennink, W. E., & Zhong, Z. (2013) · Nanomedicine · doi:10.2217/nnm.12.197 · Cited by 82 · see citing works

Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells

Wedge, D. E., Meepagala, K. M., Magee, J. B., Smith, S., Huang, G., & Larcom, L. L. (2001) · Journal of Medicinal Food · doi:10.1089/10966200152053703 · Cited by 79 · see citing works

Fresh Apples Suppress Mammary Carcinogenesis and Proliferative Activity and Induce Apoptosis in Mammary Tumors of the Sprague−Dawley Rat

Liu, J., Dong, H., Chen, B., Zhao, P., & Liu, R. H. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801826w · Cited by 77 · see citing works

Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection

Otsuki, A., Suzuki, M., Katsuoka, F., Tsuchida, K., Suda, H., Morita, M., Shimizu, R., & Yamamoto, M. P. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.005 · Cited by 70 · see citing works

A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells

Yao, Y., & Zhou, Q. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0547-2 · Cited by 65 · see citing works

Kidney-targeted astaxanthin natural antioxidant nanosystem for diabetic nephropathy therapy

Chen, Z., Li, W., Shi, L., Jiang, L., Li, M., Zhang, C., & Peng, H. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.09.005 · Cited by 61 · see citing works

Atractylenolide-I Suppresses Tumorigenesis of Breast Cancer by Inhibiting Toll-Like Receptor 4-Mediated Nuclear Factor-κB Signaling Pathway

Long, F., Lin, H., Zhang, X., Zhang, J., Xiao, H., & Wang, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.598939 · Cited by 57 · see citing works

The phytochemistry, pharmacokinetics, pharmacology and toxicity of Euphorbia semen

Zhu, A., Zhang, T., & Wang, Q. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.08.024 · Cited by 55 · see citing works

Disordered signaling governing ferroportin transcription favors breast cancer growth

Chen, Y., Zhang, S., Wang, X., Guo, W., Wang, L., Zhang, D., Yuan, L., Zhang, Z., Xu, Y., & Liu, S. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.11.002 · Cited by 54 · see citing works

Fabrication and characterization of solid lipid nano-formulation of astraxanthin against DMBA-induced breast cancer via Nrf-2-Keap1 and NF-kB and mTOR/Maf-1/PTEN pathway

Sun, T., Gao, J., Han, D., Shi, H., & Liu, X. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1667454 · Cited by 52 · see citing works

Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation

Zhou, X., Zhao, Y., Wang, J., Wang, X., Chen, C., Yin, D., Zhao, F., Yin, J., Guo, M., Zhang, L., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.006 · Cited by 50 · see citing works

Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer

Singh, B. P., Bhat, N. K., & Bhat, H. K. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr237 · Cited by 49 · see citing works

A loop involving NRF2, miR‐29b‐1‐5p and AKT, regulates cell fate of MDA‐MB‐231 triple‐negative breast cancer cells

BLASIO, A. D., Fiore, R. D., Pratelli, G., Drago‐Ferrante, R., Saliba, C., Baldacchino, S., Grech, G., Scerri, C. A., Vento, R., & Tesoriere, G. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29062 · Cited by 49 · see citing works

Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats

Rajakumar, T., Pugalendhi, P., & Thilagavathi, S. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.02.015 · Cited by 44 · see citing works

Disease Subtype–Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A

Samanta, S. K., Sehrawat, A., Kim, S., Hahm, E., Shuai, Y., Roy, R., Pore, S. K., Singh, K. B., Christner, S. M., Beumer, J. H., et al. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw293 · Cited by 44 · see citing works

Daphnetin ameliorates 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis through Nrf-2-Keap1 and NF-κB pathways

Kumar, A., Jha, S., & Pattanayak, S. P. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.05.028 · Cited by 43 · see citing works

Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?

Kuran, D., Pogorzelska, A., & Wiktorska, K. (2020) · Nutrients · doi:10.3390/nu12061559 · Cited by 43 · see citing works

Chemoprevention of Breast Cancer by Dietary Compounds

Vadodkar, A. S., Suman, S., Lakshmanaswamy, R., & Damodaran, C. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012803833008 · Cited by 41 · see citing works

Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells

Kang, H. J., Hong, Y. B., Kim, H. J., Wang, A., & Bae, I. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.12.002 · Cited by 40 · see citing works

Allyl isothiocyanate, a potent chemopreventive agent targets AhR/Nrf2 signaling pathway in chemically induced mammary carcinogenesis

Rajakumar, T., Pugalendhi, P., Thilagavathi, S., Ananthakrishnan, D., & Gunasekaran, K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3091-0 · Cited by 34 · see citing works

Chemopreventive effects of atractylenolide II on mammary tumorigenesis via activating Nrf2-ARE pathway

Wang, T., Long, F., Zhang, X., Yang, Y., Jiang, X., & Wang, L. (2017) · Oncotarget · doi:10.18632/oncotarget.20546 · Cited by 24 · see citing works

7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ERα, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway

Kumar, A., Sunita, P., Jha, S., & Pattanayak, S. P. (2018) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-018-0608-2 · Cited by 24 · see citing works

RNA‐seq reveals novel cancer‐selective and disease subtype‐independent mechanistic targets of withaferin A in human breast cancer cells

Hahm, E., Kim, S., Singh, K. B., & Singh, S. V. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23266 · Cited by 23 · see citing works

Screening active components of modified Xiaoyao powder as NRF2 agonists

Yang, Y., Wang, Y., Wang, T., Jiang, X., & Wang, L. (2017) · Cell Biochemistry and Function · doi:10.1002/cbf.3309 · Cited by 20 · see citing works

Betulin ameliorates 7,12‐dimethylbenz(a)anthracene‐induced rat mammary cancer by modulating MAPK and AhR/Nrf‐2 signaling pathway

Zhang, J., Zhou, B., Sun, J., Chen, H., & Yang, Z. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22779 · Cited by 18 · see citing works

Molecular changes associated with the anticancer effect of sulforaphane against Ehrlich solid tumour in mice

Abouzed, T. K., Beltagy, E. R., Kahilo, K. A., & Ibrahim, W. M. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22655 · Cited by 5 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway

He, W., Lv, C., Chen, Z., Shi, M., Zeng, C., Hou, D., & Qin, S. (2023) · Antioxidants · doi:10.3390/antiox12020236 · Cited by 76 · see citing works

Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin

Kanwugu, O. N., & Glukhareva, T. V. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109601 · Cited by 65 · see citing works

The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis

Occhiuto, C. J., Moerland, J. A., Leal, A. S., Gallo, K. A., & Liby, K. T. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.2191 · Cited by 40 · see citing works

Deciphering the roles of aryl hydrocarbon receptor (AHR) in regulating carcinogenesis

Chong, Z. X., Yong, C. Y., Ong, H. K., Yeap, S. K., & Ho, W. Y. (2023) · Toxicology · doi:10.1016/j.tox.2023.153596 · Cited by 32 · see citing works

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

Hayakawa, S., Ohishi, T., Oishi, Y., Isemura, M., & Miyoshi, N. (2022) · Antioxidants · doi:10.3390/antiox11122352 · Cited by 31 · see citing works

Hypoxia inducible factor-1α (HIF-1α) in breast cancer: The crosstalk with oncogenic and onco-suppressor factors in regulation of cancer hallmarks

Mirzaei, S., Ranjbar, B., Tackallou, S. H., & Aref, A. R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154676 · Cited by 28 · see citing works

Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new horizon in brain tumor management

Dewanjee, S., Bhattacharya, H., Bhattacharyya, C., Chakraborty, P., Fleishman, J. S., Alexiou, A. T., Papadakis, M., & Jha, S. K. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01878-2 · Cited by 29 · see citing works

The Role of Nrf2/sMAF Signalling in Retina Ageing and Retinal Diseases

Zhang, J., Zhang, T., Zeng, S., Zhang, X., Zhou, F., Gillies, M. C., & Zhu, L. (2023) · Biomedicines · doi:10.3390/biomedicines11061512 · Cited by 23 · see citing works

Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health

Shannar, A., Chou, P. J., Peter, R. M., Dave, P. D., Patel, K., Pan, Y., Xu, J., Sarwar, M. S., & Kong, A. T. (2024) · Current Pharmacology Reports · doi:10.1007/s40495-024-00388-6 · Cited by 19 · see citing works

Interplay between Nrf2 and ROS in regulating epithelial-mesenchymal transition: implications for cancer metastasis and therapy

Xu, Y., Hu, S., Chen, R., Xu, S., Yu, G., & Ji, L. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10731-9 · Cited by 18 · see citing works

Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway

Wang, P., Ma, Y., Rao, X., Luo, Q., Xiao, X., Wang, T., & Long, F. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156701 · Cited by 13 · see citing works

Chemopreventive effects of atractylenolide-III on mammary tumorigenesis via activation of the Nrf2/ARE pathway through autophagic degradation of Keap1

Long, F., Wang, P., Ma, Y., Zhang, X., & Wang, T. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116852 · Cited by 11 · see citing works

How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy

Tang, Y.-C., Chuang, Y., Chang, H.-H., Juang, S., Yen, G., Chang, J.-Y., & Kuo, C. (2023) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.3463 · Cited by 9 · see citing works

Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1–NRF2 Pathway

Li, Y., Wang, X., Li, S., Wang, L., Ding, N., She, Y., & Li, C. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x25500041 · Cited by 9 · see citing works

Hollow Spherical Curcumin Nanomicelles CUR@PLA@PF127: A New Trial on Breast Cancer Cells

El-banna, F. S., Hanafy, N. A. N., Mahfouz, M. E., & El-Kemary, M. A. (2023) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-023-0075-7 · Cited by 8 · see citing works

Treatment strategies targeting the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin pathway against triple-negative breast cancer

Ni, C.-X., Xu, J.-J., Pang, Y., & Xu, J.-J. (2025) · World Journal of Clinical Oncology · doi:10.5306/wjco.v16.i5.104623 · Cited by 4 · see citing works

Modulation of carcinogenesis with selected GRAS nutraceuticals via Keap1‐Nrf2 signaling pathway

Nair, B., Adithya, J., Chandrababu, G., Lakshmi, P. K., Koshy, J. J., Manoj, S. V., Ambiliraj, D. B., Balachandran, V., Sethi, G., & Nath, L. R. (2023) · Phytotherapy Research · doi:10.1002/ptr.7940 · Cited by 4 · see citing works

Mechanistic role of Nrf2 modulators in lipid peroxidation: a perspective towards carcinogenesis

Singh, A., Kukreti, R., Saso, L., & Kukreti, S. (2025) · Exploration of Medicine · doi:10.37349/emed.2025.1001372 · Cited by 2 · see citing works

Induction of apoptosis by ethanol extract of sapodilla leaf in HGT-1 cells involved caspase-independent signal transduction pathway and activation of Nrf2/HO-1

Tan, B. L., & Chan, L. C. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1803513 · Cited by 1 · see citing works

Antioxidant Activities of Plant Extracts (Ammannia multiflora, Ammannia coccinea, and Salix gracilistyla) Activate the Nrf2/HO-1 Signaling Pathway

Jayasingha, J. A. C. C., Choi, Y. H., Kang, C., Lee, M., Heo, M., & Kim, G. (2023) · Applied Sciences · doi:10.3390/app13116701 · Cited by 1 · see citing works

Bixin alleviates radiation-induced intestinal damage via inflammation regulation and barrier recovery

Kim, H. B., Kim, H., Oh, S., Kang, M., Park, J. H., Lee, S. B., Shim, S., Lee, H.-J., Yoo, K.-C., & Jang, H. (2025) · International Journal of Radiation Biology · doi:10.1080/09553002.2025.2505523 · Cited by 1 · see citing works

Mitigating Effect of Dietary Dioclea reflexa (Hook F) Seed Inclusion in Experimental Colon Carcinogenesis

Iliemene, U. D., & Atawodi, S. E.-O. (2023) · Journal of Food Biochemistry · doi:10.1155/2023/2823143

Association of serum carotenoids and SII among general people, based on NHANES 2001–2006

Yan, S., Nai, W., Peng, L., & Wang, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-94594-x

Milk-derived exosomes in breast cancer therapy: Mechanisms and therapeutic potential

Zhang, D., Xing, S., Wang, C., Wang, X., Rong, Y., Gan, Y., Yang, X., & Xie, N. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107953

Bioactive profiles and antimicrobial efficacy of common vegetable extracts: A review

Swain, C. K., Pradhan, M., Mohanty, P. K., Mohapatra, K. K., Beria, M., & Mohanty, S. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100592

Prognostic Potential of the NRF2 Transcription Factor in Canine Mammary Neoplasms

de Carvalho, V. D. M. P., Hielm-Björkman, A. K., Damasceno, K. A., Fontes, T. N., Vieira-Filho, C. H. D. C., Nunes, S., dos Reis, D. C., Moore, R., Barrouin‐Melo, S. M., Cassali, G. D., et al. (2026) · Cancers · doi:10.3390/cancers18071107

NRF2‐Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities

Al-Hawary, S. I. S., Vasudevan, A., Rodrigues, S. R., Turakulov, R., R.Baig, M., Nematov, O., Tailor, N. K., Singhal, D., & Nayak, P. P. (2026) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.70195

A Review on some dietary phytochemicals as potential cancer chemoprevention and chemotherapeutic agents

Aliyu, M., & Abdullahi, S. U. (2023) · Dutse Journal of Pure and Applied Sciences · doi:10.4314/dujopas.v9i2a.5

Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals

Fuentes, F., Shu, L., Lee, J. H., Su, Z., Lee, K., & Kong, A. T. (2013) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4614-9227-6_3 · Cited by 6 · see citing works

Dissecting the prevention of estrogen-dependent breast carcinogenesis through Nrf2-dependent and independent mechanisms

Giudice, A., Barbieri, A., Bimonte, S., Cascella, M., Cuomo, A., Crispo, A., D'Arena, G. F., Galdiero, M., Pepa, M. E. D., Botti, G., et al. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s183192 · Cited by 21 · see citing works

Chemopreventive effects of diverse dietary phytochemicals against DMBA-induced hamster buccal pouch carcinogenesis via the induction of Nrf2-mediated cytoprotective antioxidant, detoxification, and DNA repair enzymes

Kavitha, K., Thiyagarajan, P., Nandhini, J. R., Mishra, R., & Nagini, S. (2013) · Biochimie · doi:10.1016/j.biochi.2013.05.004 · Cited by 74 · see citing works

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression

Lee, J. H., Khor, T. O., Shu, L., Su, Z., Fuentes, F., & Kong, A. T. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.008 · Cited by 248 · see citing works