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Cited by 145Amyotrophic Lateral Sclerosis ResearchReliability and Agreement in MeasurementPsychometric Methodologies and Testing

Excellent inter‐rater, intra‐rater, and telephone‐administered reliability of the ALSFRS‐R in a multicenter clinical trial

Kaufmann, Petra, Levy, Gilbero, Montes, Jacquelina, Buchsbaum, Richaro, Barsdorf, Alexandra I., Battista, Vanessa, Arbing, Rachel, Gordon, Paul H. +14 more·2007·Amyotrophic Lateral Sclerosis
DOI 10.1080/17482960600888156
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Abstract

We wished to determine whether the Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-R) is reliable when used as primary outcome measure in a multicenter clinical trial. To establish inter-rater reliability, we randomly assigned 19 primary raters and 11 back-up raters to score nine amyotrophic lateral sclerosis (ALS) patients using the ALSFRS-R. To assess intra-rater reliability and reliability of telephone administration, we randomly assigned consecutive participants of the Clinical Trial of High Dose Coenzyme Q10 in ALS (QALS) to have in-person ALSFRS-R interviews at both screening and baseline visits (n=41 patients) or to have the ALSFRS-R interview by telephone at screening and in person at the baseline visit (n=27). An intraclass correlation coefficient (ICC) of reliability was calculated using a one-way random effects analysis of variance model. In the inter-rater reliability assessment, the primary raters performed 54 ratings on nine patients with ICC=0.93 (95% CI 0.84-0.98). For back-up raters, 32 ratings on nine patients resulted in ICC=0.93 (95% CI 0.82-0.98). The intra-rater reliability for in-person interviews was ICC = 0.95 (95% CI 0.92-0.98). The reliability of telephone administration compared to in-person interviews was ICC=0.97 (95% CI 0.93-0.98). We conclude that the ALSFRS-R shows excellent inter- and intra-rater reliability, and reliability of telephone administration when used as primary outcome measure in a multicenter ALS trial.

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Crossref · 10.1080/17482960600888156

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  • Administration of ALSFRS-R by trained non-clinicians has been demonstrated to have exemplary inter-rater, intra-rater, and telephone-administered reliability.

    “The administration of the ALSFRS-R by trained non-clinicians has been demonstrated to have exemplary inter-rater, intra-rater, and telephone-administered reliability (21).”

    From Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort (2018) · cites this paper as [21]

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Authors
Kaufmann, P., Levy, G., Montes, J., Buchsbaum, R., Barsdorf, A. I., Battista, V., Arbing, R., Gordon, P. H., Mitsumoto, H., Levin, B., Thompson, J. L. P., Kaufmann, P., Levy, G., Montes, J., Buchsbaum, R., Barsdorf, A. I., Battista, V., Arbing, R., Gordon, P. H., Mitsumoto, H., Levin, B., & Thompson, J. L. P.
Venue
Amyotrophic Lateral Sclerosis
Publisher
Informa UK Limited
Published
2007-01
Volume
8
Issue
1
Pages
42-46
ISSN
  • 1471-180X (ISSN-L)
  • 1748-2968
DOI
10.1080/17482960600888156
OpenAlex
W2022387525
Cited by
145
References
23
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 2 · 2020: 10 · 2019: 7 · 2018: 13 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 7
FWCI
5.09
Type
journal article
Language
en
Open access
closed
Locations
  • Amyotrophic Lateral Sclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (R01 NS48555, R01 NS 48125, R01NS048125, R01NS048555)
  • National Center for Research Resources (M01 RR00109, M01RR001066, M01RR000109, K12RR017648, M01-RR01066)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
  • Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
Keywords
ALSFRS-R, functional rating scale, inter-rater reliability, intra-rater reliability, telephone administration, outcome measure reliability
MeSH terms
Activities of Daily Living, Amyotrophic Lateral Sclerosis, Coenzymes, Double-Blind Method, Humans, Retrospective Studies, Severity of Illness Index, Telephone, Ubiquinone, Vitamins, Reproducibility of Results, Caregivers, Sickness Impact Profile

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