The DOI matches its Crossref record; 82 of the 83 references it cites were found in a registry or an index.
Psychological health in patients with amyotrophic lateral sclerosis
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with no known effective treatment or cure. Clinicians often expect that ALS patients will experience depression following the diagnosis because ALS is a terminal disease. The objective of the current study was to examine the evidence from the literature on psychological health in ALS patients in order to determine the prevalence and severity of depression in this population. Twenty-eight studies of ALS patients, conducted over the past 20 years, were reviewed and evaluated. The cumulative evidence suggests that clinically significant depression is neither as prevalent nor as severe as might be expected. Methodological limitations that are inherent to the measurement of depression in ALS, including the lack of appropriate instruments, small sample sizes, and reliance on cross-sectional data, have contributed to the wide range of reported results. We conclude that ALS patients are more likely to present with hopelessness and end-of-life concerns than clinically significant depression. It is important to assess a broad range of potential psychological distress early in the course of ALS, rather than focus specifically on depression, because the manner in which patients cope with their disease can affect their longevity.
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In the citing paper
“MND has been reported to be the most frequent cause of assisted suicide [5–7].”
In the citing paper
“Hopelessness is one psychological aspect which presents a significant problem for patients with MND”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as Averill et al., 2007
In the citing paper
“Apart from the benefits of being connected and valued with others, interactions were also beneficial in that they provided a chance for individuals to give back or care for others (5, 16, 17, 18, 19, 27).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“Patients could also feel sadness and grief about the losses the illness had imposed on their lives (1, 5, 12).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“In a similar way, peers friends and close others became important to individuals (4, 5, 8, 12, 16, 20, 29).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“Patients highly valued maximizing the autonomy of their actions and task functions and required that they were respected within interactions (5, 7, 8, 11, 12, 14, 15, 16, 18, 19, 20, 21, 23, 24, 25, 28).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“Further to this and more generally, relationships and interaction with others was identified as important (3, 5, 11, 14, 16, 18, 19, 20, 25, 27, 29).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“Related to this, patients consistently highlighted the need for choice and autonomy given during an interaction (5, 6, 7, 9, 12, 14, 15, 20, 24, 25, 26, 28).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“Patients described the need to retain dignity and feel respected during interactions (5, 7, 12, 13, 15, 23, 25).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“The role and care given by HCPs was identified as important in that support from health care professionals influenced participants mental well-being and coping (4, 5, 12, 14, 16, 23, 26).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“Other pragmatic adaptation included individuals continuing meaningful activities (4, 5, 7, 9, 10, 12, 14, 15, 16, 17, 18, 19, 20, 25, 27, 29) or continuing being “normal” (1, 2, 5, 7, 9, 17, 18, 24) which provided access to a sense of purpose and meaning as well as valued interactions.”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“A number of studies highlighted that patients required physical assistance in increasing quantities (5, 11, 16, 18).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“(c) Focusing on what could be done or achieved (2, 5, 6, 7, 11, 12, 13, 14, 27), rather than what they couldn't or what they had lost.”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“Individuals consistently identified the need to search for information in order to feel more in control (2, 4, 5, 9, 10, 12, 13, 14, 15, 22, 25, 26)”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“but also take action as a way of controlling aspects of their life that were controllable (2, 4, 5, 11, 12, 14, 18, 19).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
In the citing paper
“(e) Using religious faith to aid acceptance, and coping, or hoping for a miracle to occur, or life after death (5, 9, 14, 16, 20, 27, 29).”
From Patients experiences of maintaining mental well-being and hope within motor neuron disease: a thematic synthesis (2015) · cites this paper as [5]
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“Twenty-nine studies with 342 (175 male) unique individuals with MND were identified.”
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PSYCHOLOGY AND SOCIAL ASPECTS OF AMYOTROPHIC LATERAL SCLEROSIS: REVIEW
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Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis
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Amyotrophic lateral sclerosis with depression, cognitive impairment, and mortality
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Patient Care and Treatment in Amyotrophic Lateral Sclerosis
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Asymmetries of Patient Autonomy and Paternalism
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Living with ALS Perspectives of patients and next of kin
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A Study on the Anxiety Experience of Disabled Person with Progressive Rare Disease
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Reply to: Amyotrophic lateral sclerosis with depression, cognitive impairment, and mortality
Marchi, F. D., & Mazzini, L. (2020) · Acta Neurologica Scandinavica · doi:10.1111/ane.13238
Metadata
- Authors
- Averill, A. J., Kasarskis, E. J., & Segerstrom, S. C.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Segerstrom, Suzanne C.
- Venue
- Amyotrophic Lateral Sclerosis
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 8
- Issue
- 4
- Pages
- 243-254
- ISSN
- 1471-180X (ISSN-L)
- 1748-2968
- OpenAlex
- W1976849761
- Cited by
- 110
- References
- 83
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 13 · 2013: 8 · 2012: 9
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Amyotrophic Lateral Sclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Nursing › Research and Theory › Nursing care and research
- Keywords
- depression, mental health, psychological distress, hopelessness, depression prevalence, depression severity, neurodegenerative diseases, coping
- MeSH terms
- Amyotrophic Lateral Sclerosis, Depression, Humans, Mental Health, Review Literature as Topic, Prevalence
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