The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition
Open accessAbstract
Tumor metastasis is not only a sign of disease severity but also a major factor causing treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms of tumor metastasis are critical for the development of treatments and for the improvement of survival. The epithelial-mesenchymal transition (EMT) is an orderly, polygenic biological process that plays an important role in tumor cell invasion, metastasis and chemoresistance. The complex, multi-step process of EMT involves multiple regulatory mechanisms. Specifically, the PI3K/Akt signaling pathway can affect the EMT in a variety of ways to influence tumor aggressiveness. A better understanding of the regulatory mechanisms related to the EMT can provide a theoretical basis for the early prediction of tumor progression as well as targeted therapy.
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1 retracted
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RetractedThe basics of epithelial-mesenchymal transition
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
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Plasticity of cell migration: a multiscale tuning model
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Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
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Wei, R., Cortez Penso, N. E., Hackman, R. M., Wang, Y., & Mackenzie, G. G. (2019) · Nutrients · doi:10.3390/nu11081856 · Cited by 78
Recent advances in targeted drug delivery systems for resistant colorectal cancer
Sharifi-Azad, M., Fathi, M., Cho, W. C., Barzegari, A., Dadashi, H., Dadashpour, M., & Jahanban-Esfahlan, R. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02605-y · Cited by 65
Zhang, H., Steed, A., Co, M., & Chen, X. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2021.32 · Cited by 50
GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling
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Metadata
- Authors
- Xu, W., Yang, Z., & Lu, N.
- Venue
- Cell Adhesion & Migration
- Publisher
- Informa UK Limited
- Published
- 2015-07-04
- Volume
- 9
- Issue
- 4
- Pages
- 317-324
- ISSN
- 1933-6918 (ISSN-L)
- 1933-6926
- OpenAlex
- W1849856438
- Cited by
- 608
- References
- 85
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xu, W., Yang, Z., & Lu, N. (2015). A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition. Cell Adhesion & Migration. https://doi.org/10.1080/19336918.2015.1016686
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
