The Relationship of adiponectin level and ADIPOQ gene variants with BMI among young adult women
Open accessAbstract
The current study examined the effect of single nucleotide (SNPs) polymorphisms in the ADIPOQ gene (I146T and G276T) on body mass index (BMI) of young adult women. The women were divided into underweight, normal, overweight and obese according to BMI. The circulating levels of adiponectin were measured using commercially available ELISA kits. Genetic polymorphisms were genotyped using the PCR-RFLP method. G276T and I164T SNPs are common in the examined population as the frequency of G allele of 276 SNP was 54.8% and for the T allele of 164 SNP it was 41.7%. Circulating adiponectin levels were related to BMI and were lowest in the obese versus overweight, normal weight and underweight groups (p<0.01). However, ADIPOQ gene SNPs (I146T and G276T) showed no association with BMI groups. In conclusion, the results may suggest that adiponectin level, but not ADIPOQ gene SNPs, is a good indicator to BMI in young adult women.
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Adiponectin enhances fatty acid oxidation and improves insulin sensitivity.
“Adiponectin, secreted by adipocytes, enhances fatty acid oxidation and improves insulin sensitivity.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [77]
In that study, there was no association between ADIPOQ polymorphisms G276T and I164T and BMI categories.
“However, there was no association between the ADIPOQ polymorphisms and BMI categories, suggesting that while adiponectin levels are linked to BMI, the ADIPOQ gene variants G276T and I164T may not significantly influence BMI or adiponectin levels in this population [77].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [77]
During caloric restriction, higher adiponectin levels promote fat mobilization and utilization in muscle tissue, contributing to sustained fat loss.
“During caloric restriction, higher adiponectin levels promote fat mobilization and utilization in muscle tissue, contributing to sustained fat loss.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [77]
In young adult women in Jordan, circulating adiponectin levels were inversely related to BMI, with lower levels in obese participants.
“The results showed that circulating adiponectin levels were inversely related to BMI, with lower levels in obese participants compared to other groups.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [77]
ADIPOQ gene variants G276T and I164T may not significantly influence BMI or adiponectin levels in this population.
“However, there was no association between the ADIPOQ polymorphisms and BMI categories, suggesting that while adiponectin levels are linked to BMI, the ADIPOQ gene variants G276T and I164T may not significantly influence BMI or adiponectin levels in this population [77].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [77]
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Cites
The role of the novel adipocyte-derived hormone adiponectin in human disease
Díez, J. J., & Iglesias, P. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480293 · Cited by 1,113 · see citing works
Adipose tissue in control of metabolism
Luo, L., & Liu, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0211 · Cited by 708 · see citing works
Combs, T. P., Pajvani, U. B., Berg, A. H., Lin, Y., Jelicks, L. A., Laplante, M., Nawrocki, A. R., Rajala, M. W., Parlow, A. F., Cheeseboro, L., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1068 · Cited by 545 · see citing works
Vasseur, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2607 · Cited by 489 · see citing works
Liu, C., Feng, X., Li, Q., Wang, Y., Li, Q., & Hua, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.028 · Cited by 470 · see citing works
Shklyaev, S., Aslanidi, G., Tennant, M., Prima, V., Kohlbrenner, E., Kroutov, V., Campbell‐Thompson, M., Crawford, J. M., Shek, E. W., Scarpace, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2333912100 · Cited by 244 · see citing works
Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
Ohashi, K., Ouchi, N., Kihara, S., Funahashi, T., Nakamura, T., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Nagaretani, H., Kumada, M., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.049 · Cited by 203 · see citing works
Adiponectin: A potential therapeutic target for metabolic syndrome
Ghadge, A. A., Khaire, A. A., & Kuvalekar, A. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.01.004 · Cited by 188 · see citing works
Exercise Physiology Laboratory Manual
Adams, G. M., & Beam, W. C. (1997) · Medical Entomology and Zoology · Cited by 168 · see citing works
Hivert, M., Manning, A. K., McAteer, J. B., Florez, J. C., Dupuis, J., Fox, C. S., O’Donnell, C. J., Cupples, L. A., & Meigs, J. B. (2008) · Diabetes · doi:10.2337/db08-0700 · Cited by 157 · see citing works
Association of the human adiponectin gene and insulin resistance
Filippi, E., Sentinelli, F., Trischitta, V., Romeo, S., Arca, M., Leonetti, F., Mario, U. D., & Baroni, M. G. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201120 · Cited by 141 · see citing works
Gianfrancesco, M. A., Acuna, B., Shen, L., Briggs, F. B. S., Quach, H., Bellesis, K. H., BERNSTEIN, A. L., Hedström, A. K., Kockum, I. S., Alfredsson, L. S., et al. (2014) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2014.01.002 · Cited by 124 · see citing works
Filippi, E., Sentinelli, F., Romeo, S., Arca, M., Berni, A., Tiberti, C., Verrienti, A., Fanelli, M., Fallarino, M., Sorropago, G., et al. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0667-z · Cited by 124 · see citing works
Adipose Tissue and Adipokines: The Association with and Application of Adipokines in Obesity
Khan, M. A., & Joseph, F. (2014) · Scientifica · doi:10.1155/2014/328592 · Cited by 115 · see citing works
Slack, T., Myers, C. A., Martin, C. K., & Heymsfield, S. B. (2013) · Obesity · doi:10.1002/oby.20502 · Cited by 113 · see citing works
Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes
Fang, X., & Sweeney, G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340798 · Cited by 109 · see citing works
Cottam, D. R., Schaefer, P. A., Shaftan, G. W., Velcu, L. M., & Angus, L. D. G. (2002) · Obesity Surgery · doi:10.1381/096089202321088101 · Cited by 99 · see citing works
Xita, N. V., Georgiou, I. A., Chatzikyriakidou, A., Vounatsou, M., Papassotiriou, G.-P., Papassotiriou, I., & Tsatsoulis, A. A. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.043109 · Cited by 89 · see citing works
Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly
Yang, W., Yang, Y., Chen, C., Wu, I.-J. U., Lu, J., Lu, F.-H., Tai, T., & Chang, C.-J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.509 · Cited by 82 · see citing works
Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes
Yang, C., Kong, A. P. S., Cai, Z., & Chung, A. C. K. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0966-0 · Cited by 81 · see citing works
Developmental and Transmittable Origins of Obesity-Associated Health Disorders
Oestreich, A. K., & Moley, K. H. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.03.008 · Cited by 70 · see citing works
Reue, K. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.02.040 · Cited by 68 · see citing works
Panagiotopoulos, C., Ronsley, R. J., & Davidson, J. (2009) · The Canadian Journal of Psychiatry · doi:10.1177/070674370905401104 · Cited by 67 · see citing works
Implications of adiponectin in linking metabolism to testicular function
Martin, L. J. (2013) · Endocrine · doi:10.1007/s12020-013-0102-0 · Cited by 59 · see citing works
Lack of association between body mass index and plasma adiponectin levels in healthy adults
Kuo, S.-M., & Halpern, M. M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.20 · Cited by 57 · see citing works
Okauchi, Y., Kishida, K., Funahashi, T., Noguchi, M., Ogawa, T., Ryo, M., Okita, K., Iwahashi, H., Imagawa, A., Nakamura, T., et al. (2009) · Diabetes Care · doi:10.2337/dc09-1130 · Cited by 53 · see citing works
Serum Adiponectin in Relation to Body Mass Index and Other Correlates in Black and White Women
Cohen, S. S., Gammon, M. D., Signorello, L. B., North, K. E., Lange, E. M., Fowke, J. H., Hargreaves, M. K., Cai, Q., Zheng, W., Blot, W. J., et al. (2010) · Annals of Epidemiology · doi:10.1016/j.annepidem.2010.10.011 · Cited by 51 · see citing works
Relationship of Serum Adiponectin Levels and Metformin Therapy in Patients with Type 2 Diabetes
Su, J.-R., Lu, Z.-H., Su, Y., Zhao, N., Dong, C., Sun, L., Zhao, S., & Li, Y.-N. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0035-1569287 · Cited by 50 · see citing works
Cohen, S. S., Gammon, M. D., North, K. E., Millikan, R. C., Lange, E. M., Williams, S. M., Zheng, W., Cai, Q., Long, J., Smith, J. R., et al. (2011) · Obesity · doi:10.1038/oby.2010.346 · Cited by 48 · see citing works
Rega‐Kaun, G., Kaun, C., & Wojta, J. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-03-0212 · Cited by 46 · see citing works
Measurement of salivary adiponectin levels
Toda, M., Tsukinoki, R., & Morimoto, K. (2007) · Acta Diabetologica · doi:10.1007/s00592-007-0236-8 · Cited by 45 · see citing works
Exercise physiology laboratory manual
Pettott, R. (2009) · Medical Entomology and Zoology · Cited by 44 · see citing works
Prader-Willi Syndrome as a Model of Human Hyperphagia
Tauber, M., Diene, G., Mimoun, E., Çabal-Berthoumieu, S., Mantoulan, C., Molinas, C., Muscatelli, F., & Salles, J. (2014) · Frontiers of hormone research · doi:10.1159/000358317 · Cited by 44 · see citing works
Role of adiponectin in obesity related gastrointestinal carcinogenesis
Nagaraju, G. P., Aliya, S., & Alese, O. B. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.06.007 · Cited by 44 · see citing works
Li, Y., Li, X., Shi, L., Yang, M., Yang, Y., Tao, W., Shi, L., Xiong, Y., Zhang, Y., & Yao, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019686 · Cited by 38 · see citing works
Li, P., Jiang, R., Li, L., Liu, C., Yang, F., & Qiu, Y. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.152 · Cited by 37 · see citing works
Tsuzaki, K., Kotani, K., Sano, Y., Fujiwara, S., Gazi, I. F., Elisaf, M., & Sakane, N. (2011) · Metabolism · doi:10.1016/j.metabol.2011.06.021 · Cited by 25 · see citing works
Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration
Khabour, O. F., ABU-RUMEH, L., Al-Jarrah, M. D., Jamous, M., & Alhashimi, F. H. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1909 · Cited by 21 · see citing works
Self-citationYoshioka, K., Yoshida, T., Umekawa, T., Kogure, A., Takakura, Y., Toda, H., & Yoshikawa, T. (2004) · Metabolism · doi:10.1016/j.metabol.2004.03.021 · Cited by 21 · see citing works
Pereira, R. I., Wang, C. C., Hosokawa, P. W., Dickinson, L. M., Chonchol, M., Krantz, M. J., Steiner, J. F., Bessesen, D. H., Havranek, E. P., & Long, C. S. (2011) · BMC Endocrine Disorders · doi:10.1186/1472-6823-11-13 · Cited by 19 · see citing works
Association of Adiponectin with Hypertension in Type 2 Diabetic Patients: the Gender Effect
Khabour, O. F., Wehaibi, S. H., Al-Azzam, S. I., Alzoubi, K. H., & El-Akawi, Z. J. (2012) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2012.732645 · Cited by 17 · see citing works
Self-citationXu, L., & Lam, T. H. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12647 · Cited by 17 · see citing works
Association of adiponectin and metabolic syndrome in women.
Sanjari, M., Khodashahi, M., Gholamhoseinian, A., & Shokoohi, M. (2011) · PubMed Central · Cited by 13 · see citing works
Kotani, K., Sakane, N., Saiga, K., Tsuzaki, K., Hamada, T., & Kurozawa, Y. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.06.006 · Cited by 11 · see citing works
[Polymorphisms of adiponectin and resistin genes in patients with obesity and anorexia nervosa].
Dolinkova, M., Křížová, J., Lacinová, Z., Doležalová, R., Housova, J., Krajickova, J., Bošanská, L., Papežová, H., & Haluzı́k, M. (2006) · PubMed · Cited by 10 · see citing works
The role of adiponectin gene variants in glycemic control in patients with Type 2 diabetes
Al-Azzam, S. I., Khabour, O. F., Alzoubi, K. H., Mukattash, T. L., Ghanma, M. W., & Saleh, H. (2013) · Endocrine Research · doi:10.3109/07435800.2013.794427 · Cited by 10 · see citing works
Self-citationKim, B., Jang, Y., Paik, J. K., Kim, O. Y., Lee, S., Ordovás, J. M., & Lee, J. H. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0391 · Cited by 10 · see citing works
Cao, J., Su, S., Huang, H., Ding, N., Yin, M., Huang, M., & Zhang, X. (2012) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 49 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Theodorakis, N., Kreouzi, M., Pappas, A., & Nikolaou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413438 · Cited by 43 · see citing works
Transcriptomic landscaping of core genes and pathways of mild and severe psoriasis vulgaris
Choudhary, S., Anand, R., Pradhan, D., Bastia, B., Kumar, S. N., Singh, H., Puri, P., Thomas, G., & Jain, A. K. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4771 · Cited by 39 · see citing works
Yang, S., Zhu, T., Wakefield, J. S., Mauro, T. M., Elias, P. M., & Man, M. (2023) · Experimental Dermatology · doi:10.1111/exd.14801 · Cited by 30 · see citing works
Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence
Wong, S. K., Ramli, F. F., Ali, A., & Ibrahim, N. ‘. (2022) · Biomedicines · doi:10.3390/biomedicines10123239 · Cited by 27 · see citing works
Jack, B. U., Mamushi, M., Viraragavan, A., Dias, S. C., & Pheiffer, C. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120422 · Cited by 23 · see citing works
Natural and chemical compounds as protective agents against cardiac lipotoxicity
Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112413 · Cited by 16 · see citing works
Garba, M., Khabour, O. F., Alzoubi, K. H., Abu-Siniyeh, A. A., & Al‐Qarqaz, F. (2020) · Dermatology Research and Practice · doi:10.1155/2020/3176521 · Cited by 9 · see citing works
Self-citationArianti, R., Ariani, N. L., Muhammad, A. A., Sadewa, A. H., Farmawati, A., Sunarti, S., Hastuti, P., & Kristóf, E. (2021) · Life · doi:10.3390/life11060552 · Cited by 8 · see citing works
Obesity and the role of genetic polymorphism: A review of genes as the risk of obesity
Hastuti, P. (2022) · Journal of the Medical Sciences (Berkala Ilmu Kedokteran) · doi:10.19106/jmedsci005402202209 · Cited by 5 · see citing works
Role of Adiponectin in Cervical Cancer
Dakshinamurthy, S., Swetha, D., Momin, S., Racherla, R. G., Dakshinamurthy, E., Bharathi, T., & Gopal, D. V. R. S. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200103113330 · Cited by 3 · see citing works
Elnemr, R., Hamid, M. M. A., Taleb, R. S. Z., Khalil, N. F. W., & El-Sherif, S. M. (2024) · Human Genomics · doi:10.1186/s40246-024-00670-0 · Cited by 3 · see citing works
Associations between rs2241766 and rs3774261 polymorphisms in ADIPOQ gene and atopic dermatitis
Al-Shaheri, F. N., & Khabour, O. F. (2022) · Acta Biochimica Polonica · doi:10.18388/abp.2020_6157 · Cited by 3 · see citing works
Self-citationAl-Awad, R., Elamassie, I. T. A., Khabour, M. O., Alquraan, K. M., & Khabour, O. F. (2025) · Journal of Taibah University for Science · doi:10.1080/16583655.2025.2473763 · Cited by 2 · see citing works
Self-citationAlharbi, M. S., Khabour, O. F., & Alomari, M. A. (2023) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2023.102655 · Cited by 1 · see citing works
Self-citationMa, P. T., Tran, N. Q., Le, L. H. G., & Lam, N. V. (2025) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-031-90197-3_53 · Cited by 1 · see citing works
Ma, P. T., Tran, N. Q., Vu, M. P. H., Linh, L. G. H., & Lam, N. V. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27041780 · Cited by 1 · see citing works
Singh, C., Sharma, A., Bishnoi, M., Kondepudi, K. K., & Singh, R. P. (2020) · Springer eBooks · doi:10.1007/978-981-15-2874-3_12 · Cited by 1 · see citing works
Study of the Role of Adiponectin Gene Polymorphism in Patients with Thyroid Disorders
Kamar, M. A. G. A., Awad, M. M., Mousa, M. M., & Ragab, S. M. (2020) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2020.132882
The Complexities of Metabolic Flexibility and Precision Approaches to Sustainable Weight Management
Theodorakis, N., Kreouzi, M., Pappas, A., Feretzakis, G., Sakagianni, A., Kalodanis, K., Αναστασίου, Α., Nikolaou, M., & Koumpouros, Y. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5787-3.ch005
Saleh, R. A., Khabour, O. F., & BaniHani, M. N. (2025) · Biomedical and Biotechnology Research Journal (BBRJ) · doi:10.4103/bbrj.bbrj_311_25
Self-citationHernández‐Ramírez, S., & Guzmán-Ramos, K. R. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-7000-3_6 · Cited by 1 · see citing works
- Authors
- Khabour, O. F., Alomari, M. A., & Abu Obaid, A. A.
- Affiliations
- Jordan University of Science and Technology (JO)
- Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan 22110
- Corresponding author
- Khabour, Omar F.
- Venue
- Dermato-Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2018-01
- Volume
- 10
- Issue
- 1
- Pages
- e1477902
- ISSN
- 1938-1972 (ISSN-L)
- 1938-1980
- PMC
- PMC6298696
- OpenAlex
- W2809473516
- Cited by
- 21
- References
- 49
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 5
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Dermato-Endocrinology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Jordan University of Science and Technology (111-2014)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- adiponectin, ADIPOQ gene, single nucleotide polymorphisms, body mass index, obesity, overweight, young adult women, genetic association, circulating adiponectin levels
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