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When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions

Bradbury, Andrew R. M., Trinklein, Nathan D., Thie, Holger, Wilkinson, Ian C., Tandon, Atul K., Anderson, Stephen, Bladen, Catherine L., Jones, Brittany +17 more·2018·mAbs
DOI 10.1080/19420862.2018.1445456PMC PMC5973764
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Authors
Bradbury, A. R. M., Trinklein, N. D., Thie, H., Wilkinson, I. C., Tandon, A. K., Anderson, S., Bladen, C. L., Jones, B., Aldred, S. F., Bestagno, M., Burrone, O., Maynard, J., Ferrara, F., Trimmer, J. S., Görnemann, J., Glanville, J., Wolf, P., Frenzel, A., Wong, J., Koh, X. Y., Eng, H.-Y., Lane, D., Lefranc, M.-P., Clark, M., & Dübel, S.
Affiliations
  • Specifica Inc., 1512 Pacheco St, Santa Fe, NM, USA
  • SwitchGear Genomics, 1914 Palomar Oaks Way, Carlsbad, CA USA
  • Miltenyi Biotec GmbH, Friedrich-Ebert-Str. 68, Bergisch Gladbach, Germany
  • Absolute Antibody, Wilton Centre, Redcar, Cleveland TS10 4RF, United Kingdom
  • NeoBiotechnologies, 2 Union Square, Union City, CA, USA
  • International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste, Italy
  • The University of Texas at Austin, Cockrell School of Engineering, McKetta Department of Chemical Engineering, 200 E Dean Keeton St. Stop C0400, Austin, Texas, USA
  • Department of Physiology and Membrane Biology, University of California, Davis, One Shields Avenue, Davis, CA, USA
  • Institute for Molecular Genetics, University of Heidelberg, Im Neuenheimer Field 260, Heidelberg, Germany
  • Stanford University, School of Medicine, Stanford, California, USA
  • Department of Urology, Medical Center, University of Freiburg, Breisacher Str. 66, Freiburg, Germany
  • Yumab GmbH, Inhoffenstr. 7, Braunschweig, Germany
  • A*Star p53 laboratory, 06-06 Immunos, Singapore, Singapore
  • IMGT®, the international ImMunoGeneTics information system®, Laboratoire d'ImmunoGénétique Moléculaire LIGM, Institut de Génétique Humaine IGH, UPR CNRS 1142, Montpellier University, Montpellier cedex 5, France
  • Clark Antibodies Ltd, 10 Wellington Street, Cambridge, CB1 1HW, United Kingdom
  • Technische Universität Braunschweig, Institute of Biochemistry, Biotechnology and Bioinformatics, Spielmannstr. 7, Braunschweig, Germany
ORCID
Venue
mAbs
Publisher
Informa UK Limited
Published
2018-03-29
Volume
10
Issue
4
Pages
539-546
ISSN
  • 1942-0862
  • 1942-0870
DOI
10.1080/19420862.2018.1445456
PMC
PMC5973764
Cited by
115
References
2
Language
en

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