The serine protease Pic as a virulence factor of atypical enteropathogenic Escherichia coli

Abreu, Afonso G.; Abe, Cecilia M.; Nunes, Kamila O.; Moraes, Claudia T. P.; Chavez-Dueñas, Lucia; Navarro-Garcia, Fernando; Barbosa, Angela S.; Piazza, Roxane M. F.; Elias, Waldir P.

doi:10.1080/19490976.2015.1136775

Cited by 39Escherichia coli research studiesBacterial Genetics and BiotechnologyEnterobacteriaceae and Cronobacter Research

The serine protease Pic as a virulence factor of atypical enteropathogenic Escherichia coli

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Abreu, Afonso G., Abe, Cecilia M., Nunes, Kamila O., Moraes, Claudia T. P., Chavez-Dueñas, Lucia, Navarro-Garcia, Fernando, Barbosa, Angela S., Piazza, Roxane M. F. +1 more·2016·Gut Microbes

DOI 10.1080/19490976.2015.1136775PMC PMC4856457

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Abstract

Autotransporter proteins (AT) are associated with bacterial virulence attributes. Originally identified in enteroaggregative Escherichia coli (EAEC), Shigella flexneri 2a and uropathogenic E. coli, the serine protease Pic is one of these AT. We have previously detected one atypical enteropathogenic E. coli strain (BA589) carrying the pic gene. In the present study, we characterized the biological activities of Pic produced by BA589 both in vitro and in vivo. Contrarily to other Pic-producers bacteria, pic in BA589 is located on a high molecular weight plasmid. PicBA589 was able to agglutinate rabbit erythrocytes, cleave mucin and degrade complement system molecules. BA589 was able to colonize mice intestines, and an intense mucus production was observed. The BA589Δpic mutant lost the capacity to colonize as well as the above-mentioned in vitro activities. Thus, Pic represents an additional virulence factor in aEPEC strain BA589, associated with adherence, colonization and evasion from the innate immune system.

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The serine protease Pic produced by E. coli (EAEC), Citrobacter and Shigella flexneri is a virulence factor associated with adherence, colonization and evasion of the innate immune system.
“the serine protease Pic produced by E. coli (EAEC), Citrobacter and Shigella flexneri is a virulence factor associated with adherence, colonization and evasion of the innate immune system.68–71”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [69]
Proteases from infectious agents such as Pic in diarrheagenic E. coli and Shigella, or vibriolysin in V. cholera, degrade colonic mucus, which is a key step facilitating epithelium invasion.
“Proteases from different infectious agents such as Pic in diarrheagenic E. coli and Shigella, or vibriolysin in V. cholera, degrade the colonic mucus, which is a key step facilitating epithelium invasion.10,68,69,71”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [69]

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Authors: Abreu, A. G., Abe, C. M., Nunes, K. O., Moraes, C. T. P., Chavez-Dueñas, L., Navarro-Garcia, F., Barbosa, A. S., Piazza, R. M. F., & Elias, W. P.
Affiliations: Instituto Butantan (BR)
Corresponding author: Elias, Waldir P.
ORCID: Abreu, Afonso G.
Abe, Cecilia M.
Barbosa, Angela S.
Piazza, Roxane M. F.
Elias, Waldir P.
Venue: Gut Microbes
Publisher: Informa UK Limited
Published: 2016-03-03
Volume: 7
Issue: 2
Pages: 115-125
ISSN: 1949-0976 (ISSN-L)
1949-0984
DOI: 10.1080/19490976.2015.1136775
PMC: PMC4856457
OpenAlex: W2341787842
Cited by: 39
References: 53
Citations by year: 2026: 2 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2017: 4 · 2016: 4
FWCI: 3.54
Type: journal article
Language: en
Update notices: correction (2016-04-14)
Open access: gold
doi.org
Locations: Gut Microbes (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Enterobacteriaceae and Cronobacter Research
Keywords: atypical enteropathogenic Escherichia coli, autotransporter proteins, bacterial virulence factors, hemagglutination, intestinal colonization, mucus production, innate immune evasion
MeSH terms: Animals, Bacterial Adhesion, Escherichia coli Infections, Female, Humans, Mice, Inbred BALB C, Mucins, Rabbits, Serine Endopeptidases, Escherichia coli Proteins, Virulence Factors, Mice, Enteropathogenic Escherichia coli

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The serine protease Pic as a virulence factor of atypical enteropathogenic Escherichia coli

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