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Gut bacteria signaling to mitochondria in intestinal inflammation and cancer
Open accessAbstract
The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the intestine as well as in the pathophysiology of diseases including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Emerging evidence suggests that gut microbiota signal to the mitochondria of mucosal cells, including epithelial cells and immune cells. Gut microbiota signaling to mitochondria has been shown to alter mitochondrial metabolism, activate immune cells, induce inflammasome signaling, and alter epithelial barrier function. Both dysbiosis of the gut microbiota and mitochondrial dysfunction are associated with chronic intestinal inflammation and CRC. This review discusses mitochondrial metabolism of gut mucosal cells, mitochondrial dysfunction, and known gut microbiota-mediated mitochondrial alterations during IBD and CRC.
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“gut microbiota may regulate mitochondrial metabolism [21] and inflammation [22] by interacting with mitochondria”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway (2023) · cites this paper as [21]
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Metadata
- Authors
- Jackson, D. N., & Theiss, A. L.
- Affiliations
- Baylor University Medical Center (US)
- Corresponding author
- Theiss, Arianne L.
- ORCID
- Theiss, Arianne L.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2019-03-26
- Volume
- 11
- Issue
- 3
- Pages
- 285-304
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC7524274
- OpenAlex
- W2923380089
- Cited by
- 312
- References
- 149
- Citations by year
- 2026: 44 · 2025: 51 · 2024: 47 · 2023: 43 · 2022: 71 · 2021: 33 · 2020: 20 · 2019: 3
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Crohn’s and Colitis Foundation (391869)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK117001)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- gut microbiota, mitochondrial signaling, mitochondrial metabolism, mitochondrial dysfunction, intestinal inflammation, inflammatory bowel disease, colorectal cancer, mucosal epithelial cells, immune cells, inflammasome signaling, epithelial barrier function, dysbiosis
- MeSH terms
- Gastrointestinal Microbiome, Animals, Colitis, Humans, Inflammation, Intestinal Mucosa, Mitochondria, Colorectal Neoplasms, Inflammatory Bowel Diseases, Immunity, Mucosal
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