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Gut microbiota remodeling reverses aging-associated inflammation and dysregulation of systemic bile acid homeostasis in mice sex-specifically
Open accessAbstract
Aging is usually characterized with inflammation and disordered bile acids (BAs) homeostasis, as well as gut dysbiosis. The pathophysiological changes during aging are also sexual specific. However, it remains unclear about the modulating process among gut microbiota, BA metabolism, and inflammation during aging. In this study, we established a direct link between gut microbiota and BA profile changes in the liver, serum, and four intestinal segments of both sexes during aging and gut microbiota remodeling by co-housing old mice with young ones. We found aging reduced Actinobacteria in male mice but increased Firmicutes in female mice. Among the top 10 altered genera with aging, 4 genera changed oppositely between male and female mice, and most of the changes were reversed by co-housing in both sexes. Gut microbiota remodeling by co-housing partly rescued the systemically dysregulated BA homeostasis induced by aging in a sex- and tissue-specific manner. Aging had greater impacts on hepatic BA profile in females, but intestinal BA profile in males. In addition, aging increased hepatic and colonic deoxycholic acid in male mice, but reduced them in females. Moreover, muricholic acids shifted markedly in the intestine, especially in old male mice, and partially reversed by co-housing. Notably, the ratios of primary to secondary BAs in the liver, serum, and all four intestinal segments were increased in old mice and reduced by co-housing in both sexes. Together, the presented data revealed that sex divergent changes of gut microbiota and BA profile in multiple body compartments during aging and gut microbiota remodeling, highlighting the sex-specific prevention and treatment of aging-related disorders by targeting gut microbiota-regulated BA metabolism should particularly be given more attention.
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“metabolites previously associated with beneficial effects in aging [74, 94]”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [74]
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Metadata
- Authors
- Ma, J., Hong, Y., Zheng, N., Xie, G., Lyu, Y., Gu, Y., Xi, C., Chen, L., Wu, G., Li, Y., Tao, X., Zhong, J., Huang, Z., Wu, W., Yuan, L., Lin, M., Lu, X., Zhang, W., Jia, W., Sheng, L., & Li, H.
- Affiliations
- Shanghai University of Traditional Chinese Medicine (CN)
- Human Metabolomics Institute, Inc, Shenzhen, Guangdong, China
- University of California, Davis (US)
- Shanghai Medical College of Fudan University (CN)
- Huzhou Normal University (CN)
- Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Second Military Medical University (CN)
- Hong Kong Baptist University (HK)
- Corresponding author
- Jia, Wei
- Sheng, Lili
- Li, Houkai
- ORCID
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2020-06-09
- Volume
- 11
- Issue
- 5
- Pages
- 1450-1474
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC7524276
- OpenAlex
- W3033881211
- Cited by
- 171
- References
- 92
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 32 · 2023: 23 · 2022: 38 · 2021: 15 · 2020: 3
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (No. 81873059 & 81673662)
- National Key Research and Development Program of China (No. 2017YFC1700200)
- Program for Professor of Special Appointment (Eastern Scholar) & Shuguang Scholar
- Shanghai Institutions of Higher Learning from Shanghai Municipal Education Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- gut microbiota, aging, bile acid homeostasis, sex differences, cohousing, deoxycholic acid, muricholic acids, actinobacteria, Firmicutes, gut dysbiosis, anti-aging interventions
- MeSH terms
- Bacillota, Gastrointestinal Microbiome, Aging, Animals, Bacteria, Bile Acids and Salts, Female, Homeostasis, Housing, Animal, Inflammation, Intestine, Large, Intestine, Small, Liver, Male, Mice, Inbred C57BL, Sex Characteristics, Splenomegaly, Actinobacteria, Mice
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