The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Intestinal Cetobacterium and acetate modify glucose homeostasis via parasympathetic activation in zebrafish
Open accessAbstract
The capability of carbohydrate utilization in fish is limited compared to mammals. It has scientific and practical significance to improve the ability of fish to use carbohydrates. The efficiency of dietary carbohydrate utilization varies among fish with different feeding habits, which are associated with differential intestinal microbiota. In this study, we found that zebrafish fed with omnivorous diet (OD) and herbivorous diet (HD) showed better glucose homeostasis compared with carnivorous diet (CD) fed counterpart and the differential glucose utilization efficiency was attributable to the intestinal microbiota. The commensal bacterium Cetobacterium somerae, an acetate producer, was enriched in OD and HD groups, and administration of C. somerae in both adult zebrafish and gnotobiotic larval zebrafish models resulted in improved glucose homeostasis and increased insulin expression, supporting a causative role of C. somerae enrichment in glucose homeostasis in fish. The enrichment of C. somerae was constantly associated with higher acetate levels, and dietary supplementation of acetate promotes glucose utilization in zebrafish, suggesting a contribution of acetate in the function of C. somerae. Furthermore, we found that the beneficial effect of both acetate and C. somerae on glucose homeostasis was mediated through parasympathetic activation. Overall, this work highlights the existence of a C. somerae-brain axis in the regulation of glucose homeostasis in fish and suggests a role of acetate in mediating the axis function. Our results suggest potential strategies for improvement of fish carbohydrate utilization.
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Cites
Gut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
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“While starch is the only digestible polysaccharide, the gut microbiota synthesizes a broad spectrum of hydrolases that help the fermentation of complex dietary carbohydrates to short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate,(17) which play a pivotal role in microbiotagut-brain crosstalk.(18)…”
BackgroundGut microbiota functions: metabolism of nutrients and other food components
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Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
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Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
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Cited by
Environmental factors shaping the gut microbiome in a Dutch population
Gacesa, R., Kurilshikov, A., Vich Vila, A., Sinha, T., Klaassen, M. A. Y., Bolte, L. A., Andreu-Sánchez, S., Chen, L., Collij, V., Hu, S., et al. (2022) · Nature · doi:10.1038/s41586-022-04567-7 · Cited by 735
Bile acids as modulators of gut microbiota composition and function
Larabi, A. B., Masson, H. L. P., & Bäumler, A. J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2172671 · Cited by 401
Metadata
- Authors
- Wang, A., Zhang, Z., Ding, Q., Yang, Y., Bindelle, J., Ran, C., & Zhou, Z.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2021-01
- Volume
- 13
- Issue
- 1
- Pages
- 1-15
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- OpenAlex
- W3155171346
- Cited by
- 473
- References
- 45
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, A., Zhang, Z., Ding, Q., Yang, Y., Bindelle, J., Ran, C., & Zhou, Z. (2021). Intestinal Cetobacterium and acetate modify glucose homeostasis via parasympathetic activation in zebrafish. Gut Microbes. https://doi.org/10.1080/19490976.2021.1900996
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