The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Bile acids as modulators of gut microbiota composition and function
Open accessAbstract
Changes in the composition of gut-associated microbial communities are associated with many human illnesses, but the factors driving dysbiosis remain incompletely understood. One factor governing the microbiota composition in the gut is bile. Bile acids shape the microbiota composition through their antimicrobial activity and by activating host signaling pathways that maintain gut homeostasis. Although bile acids are host-derived, their functions are integrally linked to bacterial metabolism, which shapes the composition of the intestinal bile acid pool. Conditions that change the size or composition of the bile acid pool can trigger alterations in the microbiota composition that exacerbate inflammation or favor infection with opportunistic pathogens. Therefore, manipulating the composition or size of the bile acid pool might be a promising strategy to remediate dysbiosis.
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Metadata
- Authors
- Larabi, A. B., Masson, H. L. P., & Bäumler, A. J.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2023-02-05
- Volume
- 15
- Issue
- 1
- Pages
- 2172671-2172671
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- OpenAlex
- W4319294868
- Cited by
- 401
- References
- 194
- FWCI
- 30.26
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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