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The global epidemiology of carbapenemase-producing Enterobacteriaceae

Open access
van Duin, David, Doi, Yohei·2017·Virulence

Abstract

Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing threat to global health. Both clonal spread and plasmid-mediated transmission contribute to the ongoing rise in incidence of these bacteria. Among the 4 classes of β-lactamases defined by the Ambler classification system, the carbapenemases that confer carbapenem resistance in Enterobacteriaceae belong to 3 of them: Class A (K. pneumoniae carbapenemases, KPC), Class B (metallo-β-lactamases, MBL including New Delhi metallo-β-lactamases, NDM) and Class D (OXA-48-like carbapenemases). KPC-producing CPE are the most commonly occurring CPE in the United States. MBL-producing CPE have been most commonly associated with the Indian Subcontinent as well as with specific countries in Europe, including Romania, Denmark, Spain, and Hungary. The epicenter of OXA-48-like-producing is in Turkey and surrounding countries. Detailed knowledge of the epidemiology and molecular characteristics of CPE is essential to stem the spread of these pathogens.

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Metadata

Authors
van Duin, D., & Doi, Y.
Venue
Virulence
Published
2016-08-11
Volume
8
Issue
4
Pages
460-469
ISSN
  • 2150-5594 (ISSN-L)
  • 2150-5608
OpenAlex
W2513238037
Cited by
1,004
References
2
FWCI
28.79
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The global epidemiology of carbapenemase-producing Enterobacteriaceae. https://app.cochat.ai/papers/10.1080/21505594.2016.1222343
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van Duin, D., & Doi, Y. (2017). The global epidemiology of carbapenemase-producing Enterobacteriaceae. Virulence. https://doi.org/10.1080/21505594.2016.1222343

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