The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Role of IL-2 in cancer immunotherapy
Open accessAbstract
Interleukin-2 (IL-2) is one of the key cytokines with pleiotropic effects on immune system. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma. Recent progress has been made in our understanding of IL-2 in regulating lymphocytes that has led to exciting new directions for cancer immunotherapy. While improved IL-2 formulations might be used as monotherapies, their combination with other anticancer immunotherapies, such as adoptive cell transfer regimens, antigen-specific vaccination, and blockade of immune checkpoint inhibitory molecules, for example cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) mono-antibodies, would held the promise of treating metastatic cancer. Despite the comprehensive studies of IL-2 on immune system have established the application of IL-2 for cancer immunotherapy, a number of poignant obstacles remain for future research. In the present review, we will focus on the key biological features of IL-2, current applications, limitations, and future directions of IL-2 in cancer immunotherapy.
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1 retracted
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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
Galon, J., & Bruni, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0007-y · Cited by 3,409
Next generation of immune checkpoint therapy in cancer: new developments and challenges
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CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions
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mRNA therapeutics in cancer immunotherapy
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Metadata
- Authors
- Jiang, T., Zhou, C., & Ren, S.
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2016-04-25
- Volume
- 5
- Issue
- 6
- Pages
- e1163462
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- OpenAlex
- W2343077206
- Cited by
- 549
- References
- 83
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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