Apoptotic caspases cut down the immunogenicity of radiation
Open accessAbstract
Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon secretion. Thus, caspase inhibitors stand out as promising combinatorial partners to improve the immunogenicity of radiation therapy in the clinic.
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Similar immune effects arise from accessing extranuclear CGAS-activating DNA via permeabilized mitochondria, through autophagy or BCL2 inhibition, and from delaying caspase-dependent apoptotic breakdown after mitochondrial permeabilization.
“Similar results have been obtained by actioning extranuclear sources of CGAS-activatory DNA such as permeabilized mitochondria (by autophagy or BCL2 inhibition) (Yamazaki et al., 2020), as well as by delaying the terminal breakdown of cancer cells undergoing caspasedependent apoptosis upon mitochondrial permeabilization (Buque ´ et al., 2019; Han et al., 2020a; Rodriguez-Ruiz et al., 2019).”
From Immunomodulation by targeted anticancer agents (2021) · cites this paper as Buque ´ et al., 2019
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References 11 · Cited by 28
- Authors
- Buqué, A., Rodriguez-Ruiz, M. E., Fucikova, J., & Galluzzi, L.
- Affiliations
- Weill Cornell Medicine (US)
- Clinica Universidad de Navarra (ES)
- Charles University (CZ)
- Yale University (US)
- Corresponding author
- Galluzzi, Lorenzo
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2019-08-20
- Volume
- 8
- Issue
- 11
- Pages
- e1655364
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC6791433
- OpenAlex
- W2969395289
- Cited by
- 28
- References
- 11
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 13 · 2019: 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- OncoImmunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Defense (#BC180476P1)
- Weill Cornell Medical College
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- caspases, radiation-induced apoptosis, type I interferon, caspase inhibitors, radiotherapy, cancer immunotherapy, cancer cell death
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