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Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study
Abstract
Objective To assess the prognostic influence of pre-morbid type 2 diabetes mellitus, arterial hypertension and cardiovascular (CV) risk profile on ALS phenotype and outcome in a population-based cohort of Italian patients. Methods A total of 650 ALS patients from the Piemonte/Valle d'Aosta Register for ALS, incident in the 2007-2011 period, were recruited. Information about premorbid presence of type 2 diabetes mellitus, arterial hypertension was collected at the time of diagnosis. Patients' CV risk profile was calculated according to the Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice (JBS2). Results At the univariate analysis, the presence of pre-morbid arterial hypertension was associated with a higher age at onset of ALS and a shorter survival, and patients with a high CV risk profile had a worse prognosis than those with a low CV risk profile. The Cox multivariable analysis did not confirm such findings. Type 2 diabetes mellitus did not modify either the phenotype or the prognosis of ALS patients. Conclusions This study performed on a large population-based cohort of ALS patients has demonstrated that arterial hypertension, type 2 diabetes and CV risk factors, calculated using the Framingham equation, do not influence ALS phenotype and prognosis.
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A history of hypertension was previously linked to a higher risk of death among ALS patients.
“In line with our results, history of hypertension was previously linked to a higher risk of death among ALS patients [43, 44].”
From Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study (2024) · cites this paper as [43]
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Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Study
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Chourpiliadis, C., Seitz, C., Lovik, A., Joyce, E. E., Pan, L., Hu, Y., Kläppe, U., Samuelsson, K., Press, R., Ingre, C., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12496-w · Cited by 10
“In line with our results, history of hypertension was previously linked to a higher risk of death among ALS patients [43, 44].”
Result
Metadata
- Authors
- Moglia, C., Calvo, A., Canosa, A., Bertuzzo, D., Cugnasco, P., Solero, L., Grassano, M., Bersano, E., Cammarosano, S., Manera, U., Parals, Pisano, F., Mazzini, L., Dalla Vecchia, L. A., Mora, G., & Chiò, A.
- Affiliations
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University of Turin (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Fondazione Salvatore Maugeri (IT)
- Salvatore Maugeri Foundation, IRCSS, Scientific Institute of Milano, Milano, Italy, and
- Corresponding author
- Chiò, Adriano
- ORCID
- Venue
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Publisher
- Informa UK Limited
- Published
- 2017-06-15
- Volume
- 18
- Issue
- 7-8
- Pages
- 590-597
- ISSN
- 2167-8421 (ISSN-L)
- 2167-9223
- OpenAlex
- W2625713378
- Cited by
- 37
- References
- 2
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 1
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- Ministero della Salute
- Seventh Framework Programme
- Joint Programme - Neurodegenerative Disease Research (Sophia,Strenght)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Internal Medicine › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- amyotrophic lateral sclerosis, hypertension, type 2 diabetes, cardiovascular risk factors, prognosis, survival, age of onset, ALS phenotypes, Framingham risk equation
- MeSH terms
- Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Diabetes Mellitus, Type 2, Female, Heart Diseases, Humans, Hypertension, Italy, Male, Middle Aged, Prognosis, Registries, Risk Factors, Sensitivity and Specificity, Reproducibility of Results, Comorbidity, Prevalence, Survival Rate, Survival Analysis, Age of Onset
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