Chiò, Adriano

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 4,409

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Johnson, J. O., Mandrioli, J., Benatar, M., Abramzon, Y., Van Deerlin, V. M., Trojanowski, J. Q., Gibbs, J. R., Brunetti, M., Gronka, S., Wuu, J., et al. (2010) · Neuron

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 1,235

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Majounie, E., Renton, A. E., Mok, K., Dopper, E. G., Waite, A., Rollinson, S., Chiò, A., Restagno, G., Nicolaou, N., Simon-Sanchez, J., et al. (2012) · The Lancet Neurology

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 1,210

Prognostic factors in ALS: A critical review

Chiò, A., Logroscino, G., Hardiman, O., Swingler, R., Mitchell, D., Beghi, E., Traynor, B. G., & On Behalf of the Eurals Consortium (2009) · Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 1,172

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

Miller, T. M., Cudkowicz, M. E., Genge, A., Shaw, P. J., Sobue, G., Bucelli, R. C., Chiò, A., Van Damme, P., Ludolph, A. C., Glass, J. D., et al. (2022) · New England Journal of Medicine

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 966

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

Chiò, A., Logroscino, G., Traynor, B. J., Collins, J., Simeone, J. C., Goldstein, L. A., & White, L. A. (2013) · Neuroepidemiology

Amyotrophic Lateral Sclerosis ResearchAmyloidosis: Diagnosis, Treatment, Outcomes

Cited by 862

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N., Westra, H.-J., Bakker, O. B., Deelen, P., et al. (2021) · Nature Genetics

Amyotrophic Lateral Sclerosis ResearchGenetic Associations and Epidemiology

Cited by 542

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Chia, R., Sabir, M. S., Bandres-Ciga, S., Saez-Atienzar, S., Reynolds, R. H., Gustavsson, E., Walton, R. L., Ahmed, S., Viollet, C., Ding, J., et al. (2021) · Nature Genetics

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 438

Amyotrophic lateral sclerosis: moving towards a new classification system

Al-Chalabi, A., Hardiman, O., Kiernan, M. C., Chiò, A., Rix-Brooks, B., & van den Berg, L. H. (2016) · The Lancet Neurology

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 390

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Rubino, E., Rainero, I., Chiò, A., Rogaeva, E., Galimberti, D., Fenoglio, P., Grinberg, Y., Isaia, G., Calvo, A., Gentile, S., et al. (2012) · Neurology

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 286

Amyotrophic lateral sclerosis: translating genetic discoveries into therapies

Akçimen, F., Lopez, E. R., Landers, J. E., Nath, A., Chiò, A., Chia, R., & Traynor, B. J. (2023) · Nature Reviews Genetics

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 234

The multistep hypothesis of ALS revisited: The role of genetic mutations

Chiò, A., Mazzini, L., D'Alfonso, S., Corrado, L., Canosa, A., Moglia, C., Manera, U., Bersano, E., Brunetti, M., Barberis, M., et al. (2018) · Neurology

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 212

ALS in Italian professional soccer players: The risk is still present and could be soccer-specific

Chiò, A., Calvo, A., Dossena, M., Ghiglione, P., Mutani, R., & Mora, G. (2009) · Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis ResearchSports injuries and prevention

Cited by 180

Neurobehavioral symptoms in ALS are negatively related to caregivers’ burden and quality of life

Chiò, A., Vignola, A., Mastro, E., Giudici, A. D., Iazzolino, B., Calvo, A., Moglia, C., & Montuschi, A. (2010) · European Journal of Neurology

Amyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment Research

Cited by 157

Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

Bartolome, F., Wu, H.-C., Burchell, V. S., Preza, E., Wray, S., Mahoney, C. J., Fox, N. C., Calvo, A., Canosa, A., Moglia, C., et al. (2013) · Neuron

Mitochondrial Function and PathologyAmyotrophic Lateral Sclerosis Research

Cited by 156

Pain in amyotrophic lateral sclerosis

Chiò, A., Mora, G., & Lauria, G. (2017) · The Lancet Neurology

Amyotrophic Lateral Sclerosis ResearchPain Mechanisms and Treatments

Cited by 134

The chromosome 9 ALS and FTD locus is probably derived from a single founder

Mok, K., Traynor, B. J., Schymick, J., Tienari, P. J., Laaksovirta, H., Peuralinna, T., Myllykangas, L., Chiò, A., Shatunov, A., Boeve, B. F., et al. (2012) · Neurobiology of Aging

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 131

The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients

Cistaro, A., Pagani, M., Montuschi, A., Calvo, A., Moglia, C., Canosa, A., Restagno, G., Brunetti, M., Traynor, B. J., Nobili, F., et al. (2014) · European Journal of Nuclear Medicine and Molecular Imaging

Amyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment Research

Cited by 129

Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial)

Mandrioli, J., D’Amico, R., Zucchi, E., Gessani, A., Fini, N., Fasano, A., Caponnetto, C., Chiò, A., Dalla Bella, E., Lunetta, C., et al. (2018) · Medicine

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 128

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

Scialò, C., Tran, T. H., Salzano, G., Novi, G., Caponnetto, C., Chiò, A., Calvo, A., Canosa, A., Moda, F., Caroppo, P., et al. (2020) · Brain Communications

Amyotrophic Lateral Sclerosis ResearchPrion Diseases and Protein Misfolding

Cited by 123

Factors predicting survival in ALS: a multicenter Italian study

Calvo, A., Moglia, C., Lunetta, C., Marinou, K., Ticozzi, N., Ferrante, G. D., Scialo, C., Sorarù, G., Trojsi, F., Conte, A., et al. (2017) · Journal of Neurology

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 122

Physical activity and amyotrophic lateral sclerosis: A European population‐based case–control study

Pupillo, E., Messina, P., Giussani, G., Logroscino, G., Zoccolella, S., Chiò, A., Calvo, A., Corbo, M., Lunetta, C., Marin, B., et al. (2014) · Annals of Neurology

Amyotrophic Lateral Sclerosis ResearchPhysical Activity and Health

Cited by 105

Anxiety undermines quality of life in ALS patients and caregivers

Vignola, A., Guzzo, A., Calvo, A., Moglia, C., Pessia, A., Cavallo, E., Cammarosano, S., Giacone, S., Ghiglione, P., & Chiò, A. (2008) · European Journal of Neurology

Amyotrophic Lateral Sclerosis ResearchNursing care and research

Cited by 89

Trauma and amyotrophic lateral sclerosis: a case–control study from a population‐based registry

Pupillo, E., Messina, P., Logroscino, G., Zoccolella, S., Chiò, A., Calvo, A., Corbo, M., Lunetta, C., Micheli, A., Millul, A., et al. (2012) · European Journal of Neurology

Amyotrophic Lateral Sclerosis ResearchSpinal Cord Injury Research

Cited by 78