The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Junctional proteins of the blood-brain barrier: New insights into function and dysfunction
Open accessAbstract
The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability. However, such alterations are also involved in remodeling the brain endothelial cell surface and regulating brain endothelial cell phenotype. This review summarizes the characteristics of brain endothelial tight, adherens and gap junctions and highlights structural and functional alterations in junctional proteins that may contribute to BBB dysfunction.
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Cites
Structure and function of the blood–brain barrier
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Cited by
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
“112,113 Vascular endothelial-cadherin, scaffolding proteins catenins, scaffolding proteins p120, plakoprotein are the main components of adherens junctions.”
BackgroundBlood-brain barrier dysfunction and recovery after ischemic stroke
Jiang, X., Andjelkovic, A. V., Zhu, L., Yang, T., Bennett, M. V. L., Chen, J., Keep, R. F., & Shi, Y. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.001 · Cited by 936
Self-citationThe Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
Crossing the blood-brain barrier with nanoparticles
Zhou, Y., Peng, Z., Seven, E. S., & Leblanc, R. M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.015 · Cited by 837
The blood-brain barrier in aging and neurodegeneration
Knox, E. G., Aburto, M. R., Clarke, G., Cryan, J. F., & O’Driscoll, C. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01511-z · Cited by 738
“The claudins, specifically claudin-5, are considered the primary sealing component of the tight junctions [10, 11].”
BackgroundInfluential
Metadata
- Authors
- Stamatovic, S. M., Johnson, A. M., Keep, R. F., & Andjelkovic, A. V.
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2016-01-02
- Volume
- 4
- Issue
- 1
- Pages
- e1154641
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- OpenAlex
- W2337369609
- Cited by
- 428
- References
- 144
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
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