Claudins and the Modulation of Tight Junction Permeability
Open accessAbstract
Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.
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Cldn5 is a major cell adhesion molecule of endothelial cells.
“Cldn5 is a major cell adhesion molecule of endothelial cells22”
From Social stress induces neurovascular pathology promoting depression (2017) · cites this paper as [22]
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“To date, 27 members of this family have been characterized in mammals [29], one of which, claudin 11 (Cldn11), has been reported to participate in the formation of tight junctions in Sertoli cells [3,4].”
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“Members of the claudin family are major driving forces in the formation of paracellular barriers (Günzel and Yu, 2013).”
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“target affected by incubation with TNFα [10], and the molecular changes in TJ composition cause a disturbance in intestinal epithelial barrier function and provoke diarrhea [11,12].”
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- Authors
- Günzel, D., & Yu, A. S. L.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Yu, Alan S. L.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2013-04
- Volume
- 93
- Issue
- 2
- Pages
- 525-569
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC3768107
- OpenAlex
- W2000422049
- Cited by
- 1,456
- References
- 5
- Citations by year
- 2026: 113 · 2025: 111 · 2024: 134 · 2023: 144 · 2022: 134 · 2021: 120 · 2020: 138 · 2019: 124 · 2018: 101 · 2017: 112 · 2016: 84 · 2015: 78 · 2014: 47 · 2013: 12 · 2012: 1
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (U01GM094627)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-062283, R01DK062283)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- claudins, tight junctions, tight junction permeability, paracellular barrier, epithelium, paracellular permeability
- MeSH terms
- Animals, Epithelium, Gene Expression Regulation, Humans, Permeability, Signal Transduction, Tight Junctions, Claudins
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