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Total Phenolic Content, Anti-Radical property and HPLC profiles of Caralluma diffusa(Wight) N.E. Br.
Abstract
The relevance of free radical mediated degenerative diseases resulted in the investigation of total phenolic content and antioxidant potential of Caralluma diffusa. Quantification of total phenolics, tannins and flavonoids were done as they are the major antioxidant agents present in the plants. Antioxidant ability was assessed through various biochemical assays like ABTS+, FRAP, metal chelating and phosphomolybdenum reduction. HPLC analysis was done to determine the active constituents. The total phenolic, tannin and flavonoid content were found in moderate amount but could be efficient enough to act as anti radical agents. The plant extracts revealed good antioxidant activity in all the assays. In ABTS radical assay, ethyl acetate extract showed better activity (809.32 µM trolox equi/g extract). The hot water extract expressed maximum activity in FRAP (805.42 mM Fe II/mg extract) and metal chelating assays (36.93 %) compared to other extracts. Methanol extract showed highest ascorbic acid equivalence (88.88 g/100 g extract) in phosphomolybdenum assay. The methanol extract also revealed the presence of gallic acid, catechin, caffeic acid and ferulic acid or its analogues. This study put forward the efficiency of C. diffusa as a natural agent to fight against free radical and diseases associated with it.
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Similar kind of observations from other species were recorded from Caralluma diffusa (Wight.) and Caralluma adscendens (Roxb.).
“Overall MCU showed better activity as compared to rest of other extracts, similar kind of observations from other species were recorded from Caralluma diffusa (Wight.) and Caralluma. adscendens (Roxb.). 18,36”
From Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1 (2017) · cites this paper as [18]
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Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1
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Metadata
- Authors
- Chandran, R., Sajeesh, T., & Parimelazhagan, T.
- Affiliations
- Bharathiar University (IN)
- ORCID
- Chandran, Rahul
- Venue
- Journal of Biologically Active Products from Nature
- Publisher
- Informa UK Limited
- Published
- 2014-05-04
- Volume
- 4
- Issue
- 3
- Pages
- 188-195
- ISSN
- 2231-1866 (ISSN-L)
- 2231-1874
- OpenAlex
- W2054866011
- Cited by
- 12
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2015: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biologically Active Products from Nature (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- total phenolic content, antioxidant activity, free radical scavenging, tannins, flavonoids, HPLC profiling, gallic acid, catechins, caffeic acid, ferulic acid, ethyl acetate extract, methanol extract, hot water extract, degenerative diseases
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