Neuroprotective Natural Products for Alzheimer’s Disease

Chen, Xin; Drew, Joshua; Berney, Wren; Lei, Wei

doi:10.3390/cells10061309

Cited by 236Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Neuroprotective Natural Products for Alzheimer’s Disease

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Chen, Xin, Drew, Joshua, Berney, Wren, Lei, Wei·2021·Cells

DOI 10.3390/cells10061309PMC PMC8225186

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Abstract

Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.

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Evidence on nutraceuticals allows projecting a scenario where Alzheimer's disease could have possible preventive treatments and/or a slowing palliative effect in patients who already suffer from it.
“such evidence allows us to project a scenario where AD could have possible preventive treatments and/or have a slowing palliative effect in patients who already suffer from it [73,74,75].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [73]
Mixtures of drugs or plant extracts might have advantages over single drugs by impacting different targets simultaneously, potentially being a more effective treatment option for Alzheimer's disease.
“Mixtures of drugs or plant extracts might have advantages over single drugs as they can impact different targets simultaneously, which could be a novel and more effective treatment option for AD (Chen et al., 2021).”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Chen et al., 2021
C. longa and B. monnieri have demonstrated slight clinical improvements.
“Consequently, although the use of some herbs, such as those of C. longa and B. monnieri, have demonstrated slight clinical improvements, many natural products such as polyphenols remain of interest in the treatment of neurodegenerative disorders [203].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [203]

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The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Chemistry and Biological Activities of Flavonoids: An Overview
Kumar, S., & Pandey, A. K. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/162750 · Cited by 5,178 · see citing works
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works
Oxidative stress, aging, and diseases
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979 · see citing works
The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety
Ekor, M. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00177 · Cited by 3,919 · see citing works
2013 Alzheimer's disease facts and figures
Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204 · see citing works
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828726f5 · Cited by 2,642 · cited 1× · see citing works
“About 3% of people aged 65–74, 17% of people between 75 and 84, and 32% of people 85 and over suffer from this disease [4,5].”
Background
The Traditional Medicine and Modern Medicine from Natural Products
Yuan, H.-D., Ma, Q., Li, Y., & Piao, G. (2016) · Molecules · doi:10.3390/molecules21050559 · Cited by 2,451 · see citing works
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works
2020 Alzheimer's disease facts and figures
(2020) · Alzheimer's & Dementia · doi:10.1002/alz.12068 · Cited by 2,353 · see citing works
Inflammation as a central mechanism in Alzheimer's disease
Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works
The cholinergic hypothesis of Alzheimer’s disease: A review of progress
Francis, P. T., Palmer, A. M., Snape, M., & Wilcock, G. K. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.137 · Cited by 2,198 · cited 1× · see citing works
“Therefore, the cholinergic hypothesis suggests that a dysfunction of cholinergic neurons in the brain contributes substantially to the cognitive decline in AD [25].”
Background
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185 · see citing works
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C. B., & Rahu, N. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7432797 · Cited by 2,088 · see citing works
Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development
Chen, G.-F., Xu, T.-H., Yan, Y., Zhou, Y.-R., Jiang, Y., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.28 · Cited by 1,965 · see citing works
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750 · see citing works
Donanemab in Early Alzheimer’s Disease
Mintun, M. A., Lo, A. C., Duggan Evans, C., Wessels, A. M., Ardayfio, P. A., Andersen, S. W., Shcherbinin, S., Sparks, J., Sims, J. R., Brys, M., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2100708 · Cited by 1,728 · see citing works
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works
Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research
Ali, B. H., Blunden, G., Tanira, M. O. M., & Nemmar, A. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.085 · Cited by 1,644 · see citing works
Alzheimer's disease: Targeting the Cholinergic System
H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551 · see citing works
Potential Role of Carotenoids as Antioxidants in Human Health and Disease
Fiedor, J., & Burda, K. (2014) · Nutrients · doi:10.3390/nu6020466 · Cited by 1,420 · see citing works
Propagation of Tau Misfolding from the Outside to the Inside of a Cell
Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808759200 · Cited by 1,252 · see citing works
Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Rani, V., Deep, G., Singh, R. K., Palle, K., & Yadav, U. C. S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.002 · Cited by 1,151 · see citing works
Tau in Alzheimer Disease and Related Tauopathies
Iqbal, K., Liu, F., Gong, C., & Grundke, I. (2010) · Current Alzheimer Research · doi:10.2174/156720510793611592 · Cited by 1,122 · see citing works
Tau-targeting therapies for Alzheimer disease
Congdon, E. E., & Sigurdsson, E. M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0013-z · Cited by 1,113 · see citing works
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works
Role of Glutamate and NMDA Receptors in Alzheimer’s Disease
Wang, R., & Reddy, P. H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160763 · Cited by 1,009 · see citing works
Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders
Islam, M. T. (2016) · Neurological Research · doi:10.1080/01616412.2016.1251711 · Cited by 989 · see citing works
Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake
Li, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972 · see citing works
Current and Future Treatments in Alzheimer Disease: An Update
Yiannopoulou, K. G., & Papageorgiou, S. G. (2020) · Journal of Central Nervous System Disease · doi:10.1177/1179573520907397 · Cited by 966 · cited 1× · see citing works
“With the substantial amount of evidence indicating that the primary causative factor in the pathogenesis of AD is the accumulation of Aβ [27], decreasing Aβ has become the major strategy in developing new therapeutics for AD [28].”
Background
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
Hanger, D. P., Anderton, B. H., & Noble, W. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.01.003 · Cited by 965 · see citing works
Alzheimer’s disease: risk factors and potentially protective measures
Silva, M. V. F., Loures, C. D. M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., & Ferriani, M. D. G. C. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0524-y · Cited by 962 · see citing works
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
Min, S.-W., Cho, S.-H., Zhou, Y., Schroeder, S., Haroutunian, V., Seeley, W. W., Huang, E. J., Shen, Y., Masliah, E., Mukherjee, C., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.044 · Cited by 949 · see citing works
Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2525967 · Cited by 810 · see citing works
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
Köpke, E., Tung, Y. C., Shaikh, S., Alonso, A. C., Iqbal, K., & Grundke-Iqbal, I. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80536-5 · Cited by 779 · see citing works
Bioavailability of bioactive food compounds: a challenging journey to bioefficacy.
Rein, M. J., Renouf, M., Cruz-Hernandez, C., Actis-Goretta, L., Thakkar, S. K., & Pinto, M. I. D. S. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04425.x · Cited by 763 · see citing works
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
Liu, F., Grundke‐Iqbal, I., Iqbal, K., & Gong, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04391.x · Cited by 759 · see citing works
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723 · see citing works
Randomized trial of verubecestat for mild-to-moderate Alzheimer's disease
Egan, M. F., Kost, J., Tariot, P. N., Aisen, P. S., Cummings, J. L., Vellas, B., Sur, C., Mukai, Y., Voss, T., Furtek, C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1706441 · Cited by 685 · see citing works
Herbal extracts and phytochemicals: Plant secondary metabolites and the enhancement of human brain function
Kennedy, D. O., & Wightman, E. L. (2011) · Advances in Nutrition · doi:10.3945/an.110.000117 · Cited by 684 · see citing works
Current and future treatments for Alzheimer's disease
Yiannopoulou, K. G., & Papageorgiou, S. G. (2013) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285612461679 · Cited by 677 · see citing works
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Fusco, G., Chen, S. W., Williamson, P. T. F., Cascella, R., Perni, M., Jarvis, J. A., Cecchi, C., Vendruscolo, M., Chiti, F., Cremades, N., et al. (2017) · Science · doi:10.1126/science.aan6160 · Cited by 665 · see citing works
Microglial cell dysregulation in brain aging and neurodegeneration
von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works
Curcumin and Health
Pulido‐Moran, M., Moreno‐Fernández, J., Ramírez-Tortosa, C. L., & Ramírez-Tortosa, M. C. (2016) · Molecules · doi:10.3390/molecules21030264 · Cited by 555 · see citing works
The Alzheimer's disease Beta-secretase enzyme, BACE1
Cole, S. L., & Vassar, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-22 · Cited by 550 · see citing works
The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review
Manoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8590578 · Cited by 523 · see citing works
The discovery of Alzheimer's disease
Hippius, H., & Neundörfer, G. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.1/hhippius · Cited by 516 · see citing works
Curcumin Inhibits LPS-Induced Neuroinflammation by Promoting Microglial M2 Polarization via TREM2/TLR4/NF-Κb Pathways in BV2 Cells
Zhang, J., Zheng, Y., Luo, Y., Du, Y., Zhang, X., & Fu, J. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.09.020 · Cited by 464 · see citing works
Alcohol, dementia and cognitive decline in the elderly: a systematic review
Peters, R., Peters, J., Warner, J., Beckett, N., & Bulpitt, C. (2008) · Age and Ageing · doi:10.1093/ageing/afn095 · Cited by 453 · see citing works
REVIEW: Curcumin and Alzheimer’s disease
Hamaguchi, T., Ono, K., & Yamada, M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00147.x · Cited by 450 · see citing works
Acetylcholine modulation of neural systems involved in learning and memory
Gold, P. E. (2003) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2003.07.003 · Cited by 448 · see citing works
Bacopa monniera, a reputed nootropic plant: An overview
Russo, A., & Borrelli, F. (2005) · Phytomedicine · doi:10.1016/j.phymed.2003.12.008 · Cited by 447 · see citing works
The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics
Kent, S. A., Spires-Jones, T. L., & Durrant, C. S. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02196-w · Cited by 446 · see citing works
Challenges for Research on Polyphenols from Foods in Alzheimer’s Disease: Bioavailability, Metabolism, and Cellular and Molecular Mechanisms
Singh, M., Arseneault, M., Sanderson, J. T., Murthy, V., & Ramassamy, C. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0735073 · Cited by 438 · see citing works
Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders
Howes, M. R., Perry, N. S. L., & Houghton, P. J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1280 · Cited by 418 · see citing works
Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders
Singh, S. K., Srivastav, S., Castellani, R. J., Plascencia‐Villa, G., & Perry, G. L. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00767-8 · Cited by 402 · see citing works
Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects
Singh, R., Parihar, P., Singh, M., Bajguz, A., Kumar, J., Singh, S., Singh, V. P., & Prasad, S. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00515 · Cited by 399 · see citing works
Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications
Cosme, P., Rodríguez, A. B., Espino, J., & Garrido, M. (2020) · Antioxidants · doi:10.3390/antiox9121263 · Cited by 392 · see citing works
NRF2-regulation in brain health and disease: Implication of cerebral inflammation
Sandberg, M., Patil, J., D’Angelo, B., Weber, S. G., & Mallard, C. E. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.11.004 · Cited by 389 · see citing works
Galantamine
Scott, L. J., & Goa, K. L. (2000) · Drugs · doi:10.2165/00003495-200060050-00008 · Cited by 383 · see citing works
Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection
Singh, M., Kaur, M., Kukreja, H., Chugh, R., Silakari, O., & Singh, D. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.09.050 · Cited by 364 · see citing works
Contribution of Alzheimer disease to mortality in the United States
James, B. D., Leurgans, S. E., Hebert, L. E., Scherr, P. A., Yaffe, K. S., & Bennett, D. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000240 · Cited by 364 · see citing works
Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease
Hartman, R. E., Shah, A., Fagan, A. M., Schwetye, K. E., Parsadanian, M., Schulman, R. N., Finn, M. B., & Holtzman, D. M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.006 · Cited by 358 · see citing works
Curry Consumption and Cognitive Function in the Elderly
Ng, T. P., Chiam, P., Lee, T. M., Chua, H.-C., Lim, L. E. C., & Kua, E. H. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj267 · Cited by 353 · see citing works
Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy
Murray, A. P., Faraoni, M. B., Castro, M., Alza, N. P., & Cavallaro, V. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040004 · Cited by 352 · see citing works
Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors
Salminen, A., Ojala, J. O., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.001 · Cited by 350 · see citing works
Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease
Loureiro, J. A., Andrade, S., Duarte, A., Neves, A. R., Queiroz, J. F., Nunes, C., Sevin, E., Fénart, L., Gosselet, F., Coelho, M. A. N., et al. (2017) · Molecules · doi:10.3390/molecules22020277 · Cited by 342 · see citing works
Apolipoprotein E Polymorphism and Alzheimer Disease
Ganguli, M., Chandra, V., Kamboh, M. I., Johnston, J. M., Dodge, H. H., Thelma, B. K., Juyal, R. C., Pandav, R. S., Belle, S. H., & DeKosky, S. T. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.824 · Cited by 337 · see citing works
Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties
Lee, J., Hou, M., Huang, H., Chang, F., Yeh, C.-C., Tang, J., & Chang, H. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-55 · Cited by 334 · see citing works
Carotenoids—Antioxidant Properties
Young, A. J., & Lowe, G. (2018) · Antioxidants · doi:10.3390/antiox7020028 · Cited by 333 · see citing works
Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
Yu, M., Li, H., Liu, Q., Liu, F., Tang, L., Li, C., Yuan, Y., Zhan, Y., Xu, W., Li, W., et al. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.01.014 · Cited by 319 · see citing works
Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model
Zhao, L., Wang, J., Liu, R., Li, X., Li, J., & Zhang, L. (2013) · Molecules · doi:10.3390/molecules18089949 · Cited by 311 · see citing works
Cognitive enhancement and neuroprotective effects of Bacopa monnieri in alzheimer’s disease model
Uabundit, N., Wattanathorn, J., Mucimapura, S., & Ingkaninan, K. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.09.056 · Cited by 282 · see citing works
Nanolipidic particles improve the bioavailability and α-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease
Smith, A., Giunta, B., Bickford, P. C., Fountain, M., Tan, J., & Shytle, R. D. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.012 · Cited by 280 · see citing works
Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation
Abe, K., & Saito, H. (2000) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(200005)14:3 · Cited by 271 · see citing works
Potential medicinal plants for CNS disorders: an overview
Kumar, V. (2006) · Phytotherapy Research · doi:10.1002/ptr.1970 · Cited by 268 · see citing works
Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's β-amyloid fibrils in vitro
Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.008 · Cited by 264 · see citing works
Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
Sairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 250 · see citing works
Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats
Veerendra Kumar, M., & Gupta, Y. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03842.x · Cited by 249 · see citing works
The NLRP3 Inflammasome in Alzheimer’s Disease
Tan, M., Yu, J., Jiang, T., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8475-x · Cited by 249 · see citing works
Self-Assembly of Phenylalanine Oligopeptides: Insights from Experiments and Simulations
Tamamis, P., Adler‐Abramovich, L., Reches, M., Marshall, K. E., Sikorski, P., Serpell, L. C., Gazit, E., & Archontis, G. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.03.026 · Cited by 248 · see citing works
Ginkgo biloba Extracts: A Review of the Pharmacokinetics of the Active Ingredients
Ude, C., Schubert‐Zsilavecz, M., & Wurglics, M. (2013) · Clinical Pharmacokinetics · doi:10.1007/s40262-013-0074-5 · Cited by 244 · see citing works
Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats
Schmatz, R., Mazzanti, C. M. D. A., Spanevello, R. M., Stefanello, N., Gutierres, J. M., Corrêa, M., da Rosa, M. M., Rubin, M. A., Schetinger, M. R. C., & Morsch, V. M. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.032 · Cited by 241 · see citing works
Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies
Andrade, S., Ramalho, M. J., Loureiro, J. A., & Pereira, M. D. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092313 · Cited by 240 · see citing works
Kaempferol acts through mitogen‐activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells
Park, S. E., Sapkota, K., Kim, S. H., Kim, H., & Kim, S. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01389.x · Cited by 235 · see citing works
Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease
Shal, B., Ding, W., Ali, H., Kim, Y. S., & Khan, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00548 · Cited by 234 · see citing works
Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation
Kim, J.-E., You, D., Lee, C., Ahn, C., Seong, J. Y., & Hwang, J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.06.004 · Cited by 223 · see citing works
Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites
Yuan, T., Ma, H., Liu, W., Niesen, D. B., Shah, N., Crews, R., Rose, K. N., Vattem, D. A., & Seeram, N. P. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00260 · Cited by 219 · see citing works
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
Rezai-Zadeh, K. P., Ehrhart, J. C., Bai, Y., Sanberg, P. R., Bickford, P. C., Tan, J. R., & Shytle, R. D. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-41 · Cited by 217 · see citing works
Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: A comprehensive review
Venkatesan, R., Ji, E., & Kim, S. Y. (2015) · BioMed Research International · doi:10.1155/2015/814068 · Cited by 212 · see citing works
Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture
Limpeanchob, N., Jaipan, S., Rattanakaruna, S., Phrompittayarat, W., & Ingkaninan, K. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.07.039 · Cited by 206 · see citing works
It’s all about tau
Tapia‐Rojas, C., Cabezas-Opazo, F., Deaton, C. A., Vergara, E. H., Johnson, G. V. W., & Quintanilla, R. A. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.005 · Cited by 195 · see citing works
Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences
Teles, R. B. D. A., Diniz, T. C., Pinto, T. C. C., Júnior, R. G. D. O., Silva, M. G. E., de Lavor, É. M., Fernandes, A. W. C., de Oliveira, A. P., Ribeiro, F. P. R. D. A., da Silva, A. A. M., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7043213 · Cited by 193 · see citing works
Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways
Ladiwala, A. R. A., Dordick, J. S., & Tessier, P. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173856 · Cited by 190 · see citing works
Saffron as a Source of Novel Acetylcholinesterase Inhibitors: Molecular Docking and in Vitro Enzymatic Studies
Geromichalos, G. D., Lamari, F. N., Papandreou, M. A., Trafalis, D. T., Margarity, M., Papageorgiou, T., & Sinakos, Z. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300589c · Cited by 189 · see citing works
α- and β-secretase: profound changes in Alzheimer’s disease
Tyler, S., Dawbarn, D., Wilcock, G. K., & Allen, S. J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02635-9 · Cited by 188 · see citing works
Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures
Ferreira, I. L., Bajouco, M., Mota, S. I., Auberson, Y. P., Oliveira, C. R., & Rego, A. C. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.11.008 · Cited by 185 · see citing works
Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway
Thapa, A., Jett, S. D., & Chi, E. Y. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00214 · Cited by 185 · see citing works
Effects of medicinal plants on Alzheimer's disease and memory deficits
Akram, M., & Nawaz, A. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.205108 · Cited by 185 · see citing works
Neuronal Cell Death in Alzheimers Disease and a Neuroprotective Factor, Humanin
Niikura, T., Tajima, H., & Kita, Y. (2006) · Current Neuropharmacology · doi:10.2174/157015906776359577 · Cited by 184 · see citing works
NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease
Hwang, C. J., Choi, D., Park, M. H., & Hong, J. T. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527316666170807130011 · Cited by 178 · see citing works
Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model
Dhanasekaran, M., Holcomb, L. A., Hitt, A. R., Tharakan, B., Porter, J. W., Young, K. A., & Manyam, B. V. (2009) · Phytotherapy Research · doi:10.1002/ptr.2405 · Cited by 175 · see citing works
Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease
Vergallo, A., Mégret, L., Lista, S., Cavedo, E., Zetterberg, H., Blennow, K., Vanmechelen, E., Vos, A. D., Habert, M., Potier, M., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.03.009 · Cited by 173 · see citing works
Green tea catechins as a BACE1 (β-Secretase) inhibitor
Jeon, S.-Y., Bae, K., Seong, Y.-H., & Song, K. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.09.018 · Cited by 168 · see citing works
Protective Effects of Walnut Extract Against Amyloid Beta Peptide-Induced Cell Death and Oxidative Stress in PC12 Cells
Muthaiyah, B., Essa, M. M., Chauhan, V. P. S., & Chauhan, A. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0533-z · Cited by 168 · see citing works
Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners.
Wollen, K. A. (2010) · PubMed · Cited by 168 · see citing works
Anti-inflammatory Effects of Curcumin in Microglial Cells
Yu, Y., Shen, Q., Lai, Y., Park, S. Y., Ou, X., Lin, D., Jin, M., & Zhang, W. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00386 · Cited by 166 · see citing works
Erratum: NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri968 · Cited by 165 · see citing works
Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline.
Shi, J., Yu, J., Chen, X., & Xu, R.-X. (2003) · PubMed · Cited by 164 · see citing works
Self-citation
Panax ginseng as an adjuvant treatment for Alzheimer's disease
Kim, H.-J., Jung, S.-W., Kim, S.-Y., Cho, I., Kim, H., Rhim, H., Kim, M., & Nah, S.-Y. (2018) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.12.008 · Cited by 162 · see citing works
Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances
Niu, X.-Q., Chen, J.-J., & Gao, J.-Q. (2018) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2018.09.005 · Cited by 161 · see citing works
Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model
Fang, F., Chen, X., Huang, T., Lue, L., Luddy, J. S., & Yan, S. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.004 · Cited by 160 · see citing works
Self-citation
Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer’s disease: A neuropharmacological review of their bioactive constituents
Gorji, N., Moeini, R., & Memariani, Z. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.003 · Cited by 154 · see citing works
Nuclear translocation of NF-κB in cholinergic neurons of patients with Alzheimerʼs disease
Boissière‐Michot, F., Hunot, S., Faucheux, B. A., Duyckaerts, C. J., Hauw, J., Agid, Y., & Hirsch, É. C. (1997) · Neuroreport · doi:10.1097/00001756-199709080-00009 · Cited by 152 · see citing works
Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes
Kang, T.-H., Murakami, Y., Matsumoto, K., Takayama, H., Kitajima, M., Aimi, N., & Watanabe, H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02581-5 · Cited by 152 · see citing works
Effects of several quinones on insulin aggregation
Gong, H., He, Z., Peng, A., Zhang, X., Cheng, B., Sun, Y., Zheng, L., & Huang, K. (2014) · Scientific Reports · doi:10.1038/srep05648 · Cited by 150 · see citing works
6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia
Moon, M., Kim, H. G., Choi, J. G., Oh, H., Lee, P. K. J., Ha, S. K., Kim, S. Y., Park, Y., Huh, Y., & Oh, M. S. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.121 · Cited by 150 · see citing works
Pomegranate Polyphenols and Extract Inhibit Nuclear Factor of Activated T-Cell Activity and Microglial Activation In Vitro and in a Transgenic Mouse Model of Alzheimer Disease
Rojanathammanee, L., Puig, K. L., & Combs, C. K. (2013) · Journal of Nutrition · doi:10.3945/jn.112.169516 · Cited by 150 · see citing works
Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera
Dhanasekaran, M., Tharakan, B., Holcomb, L. A., Hitt, A. R., Young, K. A., & Manyam, B. V. (2007) · Phytotherapy Research · doi:10.1002/ptr.2195 · Cited by 148 · see citing works
Beneficial Effects of Walnuts on Cognition and Brain Health
Chauhan, A., & Chauhan, V. P. S. (2020) · Nutrients · doi:10.3390/nu12020550 · Cited by 147 · see citing works
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Perez‐Nievas, B. G., Bertrand, H. C., Martinez, P., Callard, R., Snoeren, I., Cochemé, H. M., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006593 · Cited by 146 · see citing works
Natural product for the treatment of Alzheimer’s disease
Bui, T. T., & Nguyễn, T. H. (2017) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2016-0147 · Cited by 146 · see citing works
Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases
Cho, K. S., Shin, M., Kim, S., & Lee, S. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4120458 · Cited by 142 · see citing works
Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK 3β Pathway in Streptozotocin‐Induced A lzheimer Rat Model
Gao, C., Liu, Y., Jiang, Y., Ding, J., & Li, L. (2013) · Brain Pathology · doi:10.1111/bpa.12116 · Cited by 141 · see citing works
Quercetin Inhibits Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglial Cells by Suppressing the NF-Κb Pathway and Activating the Nrf2-dependent HO-1 Pathway
Kang, C.-H., Choi, Y. H., Moon, S.-K., Kim, W.-J., & Kim, G.-Y. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.09.009 · Cited by 138 · see citing works
Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device
Eyjolfsdottir, H., Eriksdotter, M., Linderoth, B., Lind, G., Juliusson, B., Kusk, P., Almkvist, O., Andreasen, N., Blennow, K., Ferreira, D., et al. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0195-9 · Cited by 137 · see citing works
Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway
Kim, H., Kang, C., Jayasooriya, R. G. P. T., Dilshara, M. G., Lee, S., Choi, Y. H., Seo, Y. T., & Kim, G. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.03.022 · Cited by 136 · see citing works
Antioxidant Therapies for Neuroprotection—A Review
Teleanu, R. I., Chircov, C., Grumezescu, A. M., Volceanov, A., & Teleanu, D. M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101659 · Cited by 135 · see citing works
Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells
Bermejo-Bescós, P., Piñero-Estrada, E., & Villar del Fresno, Á. M. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.05.004 · Cited by 134 · see citing works
Ginkgo Biloba for Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Yang, G., Wang, Y., Sun, J., Zhang, K., & Liu, J. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150813143520 · Cited by 131 · see citing works
Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats
Zhao, H., Li, N., Wang, Q.-N., Cheng, X., Li, X. M., & Liu, T. T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.006 · Cited by 131 · see citing works
Protection by EGb 761 against β-amyloid-induced neurotoxicity: Involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
Longpré, F., Garneau, P., Christen, Y., & Ramassamy, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.08.015 · Cited by 131 · see citing works
Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
Ansari, N., & Khodagholi, F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040005 · Cited by 131 · see citing works
Exploring the Role of “Brahmi” (Bacopa monnieri and Centella asiatica) in Brain Function and Therapy
G.K., S., Muralidhara, & M.S. Bharath, M. (2011) · Recent Patents on Endocrine, Metabolic & Immune Drug Discovery · doi:10.2174/187221411794351833 · Cited by 131 · see citing works
Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice
Eckert, A., Hauptmann, S., Scherping, I., Meinhardt, J., Rhein, V. F., Dröse, S., Brandt, U., Fändrich, M., Müller, W. E., & Götz, J. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0391-6 · Cited by 129 · see citing works
Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale).
Oboh, G., Ademiluyi, A., & Akinyemi, A. J. (2012) · Experimental and Toxicological Pathology · doi:10.1016/j.etp.2010.09.004 · Cited by 128 · see citing works
Treatment Strategies Targeting Amyloid -ProteinPreprint
Schenk, D., Basi, G. S., & Pangalos, M. N. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006387 · Cited by 128 · see citing works
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β-amyloid proteins
Fujiwara, H., Iwasaki, K., Furukawa, K., Seki, T., He, M. T., Maruyama, M., Tomita, N., Kudo, Y., Higuchi, M., Saido, T. C., et al. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20891 · Cited by 127 · see citing works
An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine
Sethiya, N. K. (2009) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20091101 · Cited by 127 · see citing works
Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells.
Choi, S. K., Park, Y. S., Choi, D., & Chang, H. I. (2008) · PubMed · Cited by 127 · see citing works
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works
Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach
Thomas, S. N., Funk, K. E., Wan, Y., Liao, Z., Davies, P., Kuret, J., & Yang, A. J. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0893-0 · Cited by 123 · see citing works
Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases
Renaud, J., & Martinoli, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081883 · Cited by 122 · see citing works
Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer’s Disease: Present Status and Future Opportunities
Ovais, M., Zia, N., Ahmad, I., Khalil, A., Raza, A., Ayaz, M., Sadiq, A., Ullah, F., & Shinwari, Z. K. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00284 · Cited by 120 · see citing works
Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease
Sharma, A., Weber, D., Raupbach, J., Dakal, T. C., Fließbach, K., Ramirez, A., Grune, T., & Wüllner, U. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101546 · Cited by 120 · see citing works
Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease.
Calabrese, V., Butterfield, D. A., & Stella, A. M. G. (2003) · PubMed · Cited by 119 · see citing works
MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models
Du, Y., Du, Y., Zhang, Y., Huang, Z., Fu, M., Li, J., Pang, Y., Lei, P., Wang, Y. T., Song, W., et al. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0091-4 · Cited by 117 · see citing works
An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients
Liu, H., Ye, M., & Guo, H. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01688 · Cited by 116 · see citing works
Carotenoids and Alzheimer’s Disease: An insight into therapeutic role of retinoids in animal models
Obulesu, M., Dowlathabad, M. R., & Bramhachari, P. V. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.04.004 · Cited by 115 · see citing works
Effects of turmeric on Alzheimer′s disease with behavioral and psychological symptoms of dementia
Hishikawa, N., Takahashi, Y., Amakusa, Y., Tanno, Y., Tuji, Y., Niwa, H., Murakami, N., & Krishna, U. (2012) · AYU (An International Quarterly Journal of Research in Ayurveda) · doi:10.4103/0974-8520.110524 · Cited by 115 · see citing works
Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer’s Disease Target
Kaufmann, D., Dogra, A. K., Tahrani, A., Herrmann, F., & Wink, M. (2016) · Molecules · doi:10.3390/molecules21091161 · Cited by 115 · see citing works
Salvia miltiorrhiza: A source for anti-Alzheimer’s disease drugs
Zhang, X., Qian, S., Zhang, Y.-J., & Wang, R. L. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2015.1027408 · Cited by 114 · see citing works
Alzheimers and Dementia in the Oldest-Old: A Century of Challenges
Kawas, C. H., & Corrada, M. M. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025233 · Cited by 112 · see citing works
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway
Frandsen, J. R., & Narayanasamy, P. (2017) · Redox Biology · doi:10.1016/j.redox.2017.10.015 · Cited by 112 · see citing works
Neuroprotective potency of some spice herbs, a literature review
Khazdair, M. R., Anaeigoudari, A., Hashemzehi, M., & Mohebbati, R. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2018.01.002 · Cited by 112 · see citing works
Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease
Anandhan, A., Tamilselvam, K., Radhiga, T., Rao, S., Essa, M. M., & Manivasagam, T. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.021 · Cited by 111 · see citing works
Antibacterial and antifungal activities of extracts of Zanthoxylum chalybeum and Warburgia ugandensis, Ugandan medicinal plants.
Olila, D., Olwa‐Odyek, & Opuda‐Asibo, J. (2001) · African Health Sciences · Cited by 109 · see citing works
SpirulinaandC-phycocyaninreduce cytotoxicity and inflammation-related genes expression of microglial cells
Chen, J.-C., Liu, K. S., Yang, T.-J., Hwang, J.-H., Chan, Y., & Lee, I. (2012) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000020 · Cited by 109 · see citing works
Exploring the Effect of Phyllanthus emblica L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer's Disease
Uddin, M. S., Mamun, A. A., Hossain, M. S., Akter, F., Iqbal, M. A., & Asaduzzaman, M. (2016) · Annals of Neurosciences · doi:10.1159/000449482 · Cited by 109 · see citing works
Supplementation of Convolvulus pluricaulis attenuates scopolamine-induced increased tau and Amyloid precursor protein (AβPP) expression in rat brain
Bihaqi, S. W., Singh, A., & Tiwari, M. (2012) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.100383 · Cited by 108 · see citing works
Exploring the efficacy of natural products in alleviating Alzheimer’s disease
Singh, A., Deshpande, P., & Gogia, N. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.253509 · Cited by 108 · see citing works
Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: A brief overview
Leone, S., Recinella, L., Chiavaroli, A., Orlando, G., Ferrante, C., Leporini, L., Brunetti, L., & Menghini, L. (2018) · Phytotherapy Research · doi:10.1002/ptr.6181 · Cited by 106 · see citing works
Effects of walnut consumption on cognitive performance in young adults
Pribis, P., Bailey, R. N., Russell, A. A., Kilsby, M., Hernandez, M., Craig, W. J., Grajales, T., Shavlik, D. J., & Sabaté, J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004302 · Cited by 105 · see citing works
Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophylla (Miq) jack and Gastrodia elata Bl., in kainic acid-treated rats
Hsieh, C., Tang, N.-Y., Chiang, S., Hsieh, C.-T., & Lin, J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00473-7 · Cited by 104 · see citing works
Improvement of Cognitive Deficit in Alzheimer's Disease Patients by Long Term Treatment with Korean Red Ginseng
Heo, J., Lee, S., Oh, M.-J., Park, H.-J., Shim, J.-Y., Chu, K., & Kim, M. (2011) · Journal of Ginseng Research · doi:10.5142/jgr.2011.35.4.457 · Cited by 102 · see citing works
Minocycline reduces inflammatory parameters in the brain structures and serum and reverses memory impairment caused by the administration of amyloid β (1-42) in mice
Garcez, M. L., Mina, F., Bellettini-Santos, T., Carneiro, F. G., Luz, A. P., Schiavo, G. L., Andrighetti, M. S., Scheid, M. G., Bolfe, R. P., & Budni, J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.03.010 · Cited by 102 · see citing works
Molecular basis for induction of ocular dominance plasticity
Bear, M. F., & Rittenhouse, C. D. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199910)41:1 · Cited by 99 · see citing works
Repeated administration of almonds increases brain acetylcholine levels and enhances memory function in healthy rats while attenuates memory deficits in animal model of amnesia
Batool, Z., Sadir, S., Liaquat, L., Tabassum, S., Madiha, S., Rafiq, S., Tariq, S., Batool, T. S., Saleem, S., Naqvi, F. F., et al. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.11.001 · Cited by 99 · see citing works
Neuroprotective Effects of Aged Garlic Extract on Cognitive Dysfunction and Neuroinflammation Induced by β-Amyloid in Rats
Nillert, N., Pannangrong, W., Welbat, J. U., Chaijaroonkhanarak, W., Sripanidkulchai, K., & Sripanidkulchai, B. (2017) · Nutrients · doi:10.3390/nu9010024 · Cited by 99 · see citing works
A critical review on grape polyphenols for neuroprotection: Strategies to enhance bioefficacy
Zhao, D., Simon, J. E., & Wu, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1546668 · Cited by 99 · see citing works
Therapeutic impact of grape leaves polyphenols on certain biochemical and neurological markers in AlCl3-induced Alzheimer’s disease
Borai, I. H., Ezz, M. K., Rizk, M. Z., Aly, H. F., El-Sherbiny, M., Matloub, A. A., & Fouad, G. I. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.038 · Cited by 98 · see citing works
Punicalagin inhibits neuroinflammation in LPS‐activated rat primary microglia
Olajide, O. A., Kumar, A., Velagapudi, R., Okorji, U. P., & Fiebich, B. L. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400163 · Cited by 94 · see citing works
Dietary Modulation of Oxidative Stress in Alzheimer’s Disease
Thapa, A., & Carroll, N. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071583 · Cited by 94 · see citing works
Neuroprotective Effects of Garlic A Review
Mathew, B., & Biju, R. S. (2008) · Libyan Journal of Medicine · doi:10.4176/071110 · Cited by 93 · see citing works
Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
He, X., Li, Z., Rizak, J. D., Wu, S., Wang, Z., He, R., Su, M., Qin, D., Wang, J., & Hu, X. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00598 · Cited by 93 · see citing works
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de Oliveira, M. R., Ferreira, G. C., & Schuck, P. F. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.12.005 · Cited by 92 · see citing works
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Yuan, C., Chen, H., Wang, Y., Schneider, J. A., Willett, W. C., & Morris, M. C. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa303 · Cited by 91 · see citing works
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Subash, S., Essa, M. M., Al-Asmi, A. R., Al‐Adawi, S., Vaishnav, R., Braidy, N., Manivasagam, T., & Guillemin, G. J. (2014) · Journal of Traditional and Complementary Medicine · doi:10.4103/2225-4110.139107 · Cited by 90 · see citing works
Nootropic, anxiolytic and CNS-depressant studies on different plant sources ofshankhpushpi
Malik, J., Karan, M., & Vasisht, K. (2011) · Pharmaceutical Biology · doi:10.3109/13880209.2011.584539 · Cited by 89 · see citing works
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Abulfadl, Y., El‐Maraghy, N. N., Ahmed, A. A. E., Nofal, S., Abdel–Mottaleb, Y., & Badary, O. A. (2018) · Human & Experimental Toxicology · doi:10.1177/0960327118755256 · Cited by 89 · see citing works
Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats
Kulkarni, K., Kasture, S., & Mengi, S. (2010) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.66841 · Cited by 88 · see citing works
Clinical Development of Aducanumab, an Anti-Aβ Human Monoclonal Antibody Being Investigated for the Treatment of Early Alzheimer's Disease.
Haeberlein, S. B., O'Gorman, J. T., Chiao, P.-C., Bussière, T., von Rosenstiel, P., Tian, Y., Zhu, Y., von Hehn, C., Gheuens, S., Skordos, L., et al. (2017) · PubMed · doi:10.14283/jpad.2017.39 · Cited by 88 · see citing works
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Szurpnicka, A., Kowalczuk, A. P., & Szterk, A. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01247-w · Cited by 88 · see citing works
Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia.
Ma, X., Sun, Z., Liu, Y., Jia, Y., Zhang, B., & Zhang, J. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.22.004 · Cited by 87 · see citing works
Preserved neurogenesis in non-demented individuals with AD neuropathology
Briley, D., Ghirardi, V., Woltjer, R. L., Renck, A., Zolochevska, O., Taglialatela, G., & Micci, M. (2016) · Scientific Reports · doi:10.1038/srep27812 · Cited by 87 · see citing works
Intracerebroventricular administration of colchicine produces cognitive impairment associated with oxidative stress in rats
Kumar, M. V. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00838-9 · Cited by 86 · see citing works
Neuroprotective strategies in Alzheimer’s disease
Longo, F. M., & Massa, S. M. (2004) · NeuroRx · doi:10.1602/neurorx.1.1.117 · Cited by 83 · see citing works
Bioassay-Guided Isolation of Neuroprotective Compounds fromUncaria rhynchophyllaagainst Beta-Amyloid-Induced Neurotoxicity
Xian, Y., Lin, Z.-X., Mao, Q., Hu, Z. J., Zhao, M., Che, C., & Ip, S. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/802625 · Cited by 82 · see citing works
Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-κB signaling pathway in mice
Seong, K.-J., Lee, H.-G., Kook, M. S., Ko, H.-M., Jung, J., & Kim, W.-J. (2016) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2016.20.1.41 · Cited by 82 · see citing works
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Rajaram, S., Valls‐Pedret, C., Cofán, M., Sabaté, J., Serra‐Mir, M., Pérez-Heras, A., Aréchiga, A. E., Casaroli-Marano, R. P., Alforja, S., Sala‐Vila, A., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00333 · Cited by 79 · see citing works
Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice
El‐Shiekh, R. A., Ashour, R. M. S., El-Haleim, E. A. A., Ahmed, K. A., & Abdel-Sattar, E. A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110303 · Cited by 78 · see citing works
A β-Secretase (BACE1) Inhibitor Hispidin from the Mycelial Cultures ofPhellinus linteus
Park, I., Jeon, S.-Y., Lee, H.-J., Kim, S., & Song, K. (2004) · Planta Medica · doi:10.1055/s-2004-815491 · Cited by 77 · see citing works
Alzheimer Disease: Clues from traditional and complementary medicine
Cooper, E. L., & Ma, M. J. (2017) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2016.12.003 · Cited by 76 · see citing works
Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells
Ahn, B. R., Moon, H. E., Kim, H. R., Jung, H. A., & Choi, J. S. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-1116-5 · Cited by 75 · see citing works
Multiple Antioxidants in the Prevention and Treatment of Alzheimer Disease: Analysis of Biologic Rationale
Prasad, K. N., Hovland, A. R., Cole, W. C., Prasad, K. C., Nahreini, P., Edwards‐Prasad, J., & Andreatta, C. P. (2000) · Clinical Neuropharmacology · doi:10.1097/00002826-200001000-00002 · Cited by 74 · see citing works

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[58]Vuolo M.M. Lima V.S. Maróstica Junior M.R. Chapter 2—Phenolic Compounds: Structure, Classification, and Antioxidant Power Bioactive Compounds Campos M.R.S. Woodhead Publishing Cambridge, UK 2019 33 50

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Jiménez, M. T. B., Rivas‐García, L., Sánchez‐González, C., Grosso, G., Lipari, V., Ramírez, L. V., Battino, M. A., Giampieri, F., Quiles, J. L., & Forbes-Hernández, T. Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110631 · Cited by 17 · see citing works
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Wan, H., Wang, S., Li, C., Zeng, B., Wu, H., Liu, C., Chen, L., Jin, M., Huang, W., Zang, Y., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082157 · Cited by 14 · see citing works
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Kopalli, S., Behl, T., Kyada, A., Rekha, M., Kundlas, M., Rani, P., Nathiya, D., Naidu, K., Gulati, M., Bhise, M., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.007 · Cited by 11 · see citing works
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Onaolapo, O. J., Olofinnade, A. T., Ojo, F. O., & Onaolapo, A. Y. (2021) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523021666220815151559 · Cited by 12 · see citing works
Multi-target regulatory mechanism of Yang Xin Tang − a traditional Chinese medicine against dementia
Lo, T. Y., Chan, A. S. L., Cheung, S. T., Yung, L. Y., Leung, M. M. H., & Wong, Y. H. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00813-w · Cited by 13 · see citing works
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Suresh, S., & Vellapandian, C. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116953 · Cited by 13 · see citing works
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Yin, B., Li, X., Li, Z., Zhu, X., Zhang, L., Zhou, X., Xu, J., Chen, F., Tang, P., & Gao, F. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202306326 · Cited by 13 · see citing works
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Lee, W. S., Lee, H., Yang, J. Y., Shin, H.-L., Choi, S., Kim, J.-K., Seo, W. D., & Kim, E. H. (2022) · Nutrients · doi:10.3390/nu14194103 · Cited by 12 · see citing works
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Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2025) · Molecules · doi:10.3390/molecules30040922 · Cited by 13 · see citing works
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Wu, M., Li, Y., Miao, Y., Qiao, H., & Wang, Y. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2245582 · Cited by 9 · see citing works
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Li, K., Wang, Y., & Ni, H. (2023) · Journal of Molecular Neuroscience · doi:10.1007/s12031-023-02160-9 · Cited by 9 · see citing works
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Pang, L., Li, J., Liu, Z., Quan, Y., Sui, H., Jia, Y., Chen, F., Lee, J. J., Liu, P., Quan, Z., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114825 · Cited by 9 · see citing works
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Ryu, M. S., Yu, Y., Li, C., Yang, H.-J., Zhang, T., Wu, X., Jeong, D., & Park, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117091 · Cited by 8 · see citing works
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Zhang, Q., Li, Y., Jin, Q., Liu, Z., Chen, H., Huang, J., Liu, T., Liu, X., Tan, Z., Huang, S., et al. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.110964 · Cited by 8 · see citing works
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Júnior, A. Q. D. S., Rodrigues, G. D. S., Barroso, A. D. S., Figueiredo, P. L. B., Machado, F. P., Ferreira, M. A. J. F., Fernandes, C. P., dos Santos, G. B., & Mourão, R. H. V. (2025) · Molecules · doi:10.3390/molecules30071554 · Cited by 8 · see citing works
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Anyanwu, G. E., Umeano, A., Ojiakor, V. O., Katchy, A. U., Anyanwu, C. N., & Fakorede, S. (2025) · Journal of Experimental Pharmacology · doi:10.2147/jep.s498984 · Cited by 8 · see citing works
Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase
Cui, X., Deng, S., Li, G., Zhang, Y., Wang, L., Wu, C., & Deng, Y. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1063284 · Cited by 8 · see citing works
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Bhanukiran, K., & Priya, V., V (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156108 · Cited by 8 · see citing works
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Ittiyavirah, S. P., Kannan, R., Sathyan, A., Rajasree, R. S., Kuruniyan, M. S., Quadri, S. A., Elayadeth‐Meethal, M., & Naseef, P. P. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.10.007 · Cited by 9 · see citing works
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Go, M. J., Kim, J. M., Lee, H. L., Kim, T. Y., Joo, S. G., Kim, J. H., Lee, H. S., Kim, D., & Heo, H. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814084 · Cited by 8 · see citing works
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Zeng, J., Zhang, R., Xu, H., Zhang, C., & Li, L. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100097 · Cited by 7 · see citing works
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Hossain, M. M., Adhikari, J., & Shibly, A. Z. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100095 · Cited by 7 · see citing works
Total alkaloids from the seed embryo of Nelumbo nucifera Gaertn. improve cognitive impairment in APP/PS1 mice and protect Aβ-damaged PC12 cells
Meng, X., Xue, J., Su, S.-J., Gou, J., Lu, J., Chen, C.-L., & Xu, C. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2145426 · Cited by 7 · see citing works
Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies
Chear, N. J., Ching-Ga, T. A. F., Khaw, K. Y., León, F., Tan, W., Yusof, S. R., McCurdy, C. R., Murugaiyah, V., & Ramanathan, S. (2023) · Metabolites · doi:10.3390/metabo13030390 · Cited by 7 · see citing works
Intraperitoneal pretreatment of ellagic acid and chrysin alleviate ifosfamide-induced neurotoxicity, but betanin induces death in male wistar rats
Salimi, A., Shabani, M., Mohammadi, H., & Sudi, V. (2023) · Human & Experimental Toxicology · doi:10.1177/09603271221147883 · Cited by 7 · see citing works

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López-Romero, J. C., Moreno, H. T., Tapia-Rodríguez, M. R., Vidal-Gutiérrez, M., & Reyna-Urrutia, V. A. (2025) · CRC Press eBooks · doi:10.1201/9781003467304-10
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Ansari, N., & Khodagholi, F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040005 · Cited by 131 · see citing works
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Islam, F., Khadija, J. F., Harun-Or-Rashid, M., Rahaman, M. S., Nafady, M. H., Islam, M. R., Akter, A., Emran, T. B., Wilairatana, P., & Mubarak, M. S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5100904 · Cited by 85 · see citing works

Authors: Chen, X., Drew, J., Berney, W., & Lei, W.
Affiliations: Campbell University (US)
Presbyterian College (US)
Corresponding author: Chen, Xin
ORCID: Chen, Xin
Lei, Wei
Venue: Cells
Publisher: MDPI AG
Published: 2021-05-25
Volume: 10
Issue: 6
Pages: 1309
ISSN: 2073-4409 (ISSN-L)
DOI: 10.3390/cells10061309
PMC: PMC8225186
OpenAlex: W3165481569
Cited by: 236
References: 314
Citations by year: 2026: 41 · 2025: 53 · 2024: 54 · 2023: 54 · 2022: 30 · 2021: 4
FWCI: 8.15
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cells (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords: Alzheimer's disease, neuroprotection, natural products, natural product mixtures, plant extracts, neuroprotection mechanism
MeSH terms: Alzheimer Disease, Animals, Biological Products, Humans, Neuroprotective Agents, Drug Discovery

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