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Cited by 91Pregnancy and preeclampsia studiesBirth, Development, and HealthNeonatal and fetal brain pathology

Prognostic role of umbilical artery Doppler velocimetry in growth-restricted fetuses

Soregaroli, M., Bonera, R., Danti, L., Dinolfo, D., Taddei, F., Valcamonico, A., Frusca, T.·2002·The Journal of Maternal-Fetal & Neonatal Medicine
DOI 10.1080/jmf.11.3.199.203
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Abstract

OBJECTIVE: To correlate umbilical artery Doppler velocimetry with perinatal outcome in a group of growth-restricted fetuses. DESIGN: The study was a retrospective analysis of 578 singleton pregnancies with diagnosis of intrauterine growth restriction (IUGR), delivered in a single obstetric unit, at the Spedali Civili, Brescia, Italy, a university and teaching hospital with 3500 deliveries a year and neonatal intensive care unit (NICU). METHODS: During 1991-99 we studied 578 pregnancies with a diagnosis of IUGR referred for Doppler velocimetry. From this population, four subsets were formed: normal umbilical artery pulsatility index (NUAPI; 334 fetuses); increased pulsatility index but with telediastolic flow (abnormal umbilical artery pulsatility index AUAPI; 137 fetuses); absent end-diastolic flow (AEDF; 70 fetuses); reverse telediastolic flow (RF; 37 fetuses). Fetal biometry, amniotic fluid and fetal-maternal Doppler velocimetry were evaluated in all patients, with biophysical profile and routine non-stress test, when indicated. The following outcomes were examined: mean gestational age at delivery, number of preterm deliveries (< 34 weeks), mean neonatal weight, Apgar score at 5 min < 7, prenatal and neonatal deaths (within the first 28 days of life), admission to the NICU and number of days spent after birth in hospital. Neonatal morbidity was analyzed, including respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH, grade 2-3), necrotizing enterocolitis (NEC) and retinopathy of prematurity. Long-term neurological follow-up is still ongoing and will not be presented in this paper. RESULTS: Out of 578 fetuses with IUGR, 547 were born alive. There were 26 neonatal deaths. The mean gestational age at delivery was 35.6 +/- 4 weeks and mean birth weight 1844 +/- 612 g. There were 28 intrauterine deaths and three elective terminations of pregnancy. A total of 60 cases (11%) were complicated by RDS, 13 cases (2.4%) by retinopathy of prematurity, IVH was present in nine cases (1.6%) and NEC in seven cases (1.3%). Total perinatal mortality was 9.8%; in the 26 cases of neonatal death, the mean week at delivery was 29.6 +/- 4 with a mean weight of 840 +/- 425 g. Patients with NUAPI had a mean week at delivery of 37 +/- 3, those with AUAPI delivered at 34 +/- 3.2, those with AEDF delivered at 31 +/- 3 and those with RF delivered at 29 +/- 2 weeks. In progressively worsening umbilical velocimetry, we observed an increase of incidence of low Apgar score. Days of admission to the NICU and incidence of perinatal mortality increased with the worsening of Doppler velocimetry. CONCLUSIONS: Our study underlines the existence of a strict correlation between umbilical Doppler velocimetry and an increased incidence of perinatal complications in IUGR fetuses.

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Crossref · 10.1080/jmf.11.3.199.203

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  • The effect on the developing heart will be exaggerated in pathological pregnancies, where poor placental development is associated with absent-or reversed-end diastolic umbilical arterial flow.

    “The effect on the developing heart will be exaggerated in pathological pregnancies, where poor placental development is associated with absent-or reversed-end diastolic umbilical arterial flow (513).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [513]

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Authors
Soregaroli, M., Bonera, R., Danti, L., Dinolfo, D., Taddei, F., Valcamonico, A., & Frusca, T.
Affiliations
University of Brescia (IT)
ORCID
Venue
The Journal of Maternal-Fetal & Neonatal Medicine
Publisher
Informa UK Limited
Published
2002-01
Volume
11
Issue
3
Pages
199-203
ISSN
  • 1476-4954 (ISSN-L)
  • 1476-7058
DOI
10.1080/jmf.11.3.199.203
OpenAlex
W2022942921
Cited by
90
References
33
Citations by year
2026: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 7
FWCI
3.34
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
fetal growth restriction, umbilical artery Doppler, pulsatility index, absent end-diastolic flow, perinatal outcomes, neonatal morbidity, respiratory distress syndrome, intraventricular hemorrhage, retinopathy of prematurity, necrotizing enterocolitis, preterm birth, fetal biometry, amniotic fluid
MeSH terms
Blood Flow Velocity, Female, Fetal Growth Retardation, Humans, Pregnancy, Pregnancy Outcome, Retrospective Studies, Sensitivity and Specificity, Umbilical Arteries, Ultrasonography, Prenatal, Ultrasonography, Doppler

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