The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Evaluation of Rapidly Disintegrating Tablets Prepared by a Direct Compression Method
Abstract
To make rapidly disintegrating tablets with sufficient mechanical integrity as well as a pleasant taste, microcrystalline cellulose (MCC), Tablettose (TT), and crosslinked sodium carboxymethyl cellulose (Ac-di-sol) or erythritol (ET) were formulated. Tablets were made by a direct compression method (I). Tablet properties such as porosity, tensile strength, and disintegration time were determined. The tensile strength and disintegration time were selected as response variables, tablet porosity and parameters representing the characteristics of formulation were selected as controlling factors, and their relation was determined by the polynomial regression method. Response surface plots and contour plots of tablet tensile strength and disintegration time were also constructed. The optimum combination of tablet porosity and formulation was obtained by superimposing the contour diagrams of tablet tensile strength and disintegration time. Rapidly disintegrating tablets with durable structure and desirable taste could be prepared within the obtained optimum region.
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In the citing paper
“Tablet porosity is a reliable and fundamental critical quality attribute which controls key mass transport mechanisms that govern disintegration and dissolution behaviour.”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [26]
In the citing paper
“However, this is not always the case for certain types of disintegrants at very high tablet porosity levels (e.g., for rapidly disintegrating or dissolving tablets).”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [26]
In the citing paper
“The swelling of disintegrant like CCS has been reported to be accompanied by gel formation that can significantly prolong the disintegration time 26 .”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [26]
Citations
Cites
The Dynamics of Capillary Flow
Washburn, E. W. (1921) · Physical Review · doi:10.1103/physrev.17.273 · Cited by 7,202
Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity.
Bi, Y., Sunada, H., Yonezawa, Y., Danjo, K., OTSUKA, A., & Iida, K. (1996) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.44.2121 · Cited by 412
Self-citationNyström, C., Alderborn, G., Duberg, M., & Karehill, P.-G. (1993) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049309047189 · Cited by 237
Nogami, H., Nagai, T., Fukuoka, E., & Sonobe, T. (1969) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.17.1450 · Cited by 102
A Comparative Evaluation of the Properties of some Tablet Disintegrants
Gissinger, D., & Stamm, A. (1980) · Drug Development and Industrial Pharmacy · doi:10.3109/03639048009068720 · Cited by 78
Noda, K., Nakayama, K., & Oku, T. (1994) · PubMed · Cited by 74
Caring for the Elderly Patient
Mallet, L. (1996) · Journal of the American Pharmaceutical Association (1996) · doi:10.1016/s1086-5802(16)30157-7 · Cited by 35
Influence of Punch Velocity on the Compressibility of Granules
Danjo, K., Kimura, H., & OTSUKA, A. (1996) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049609065923 · Cited by 14
Self-citation
Research works printed but not linked: 6
- Sugihara M, 1994, Farumashia, 30, 1396
- Kearney P., 1993, Pharm. Tech. Jpn., 9, 713
- Masaki K, 1997, 22nd Conf. Pharm. Technol., 79
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Cited by
Sorted by citations
A review of disintegration mechanisms and measurement techniques
Markl, D., & Zeitler, J. A. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2129-z · Cited by 439
Orally Disintegrating Tablets: A Review
Hirani, J. J., Rathod, D., & Vadalia, K. (2009) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v8i2.44525 · Cited by 275
Fast dispersible ibuprofen tablets
Schiermeier, S., & Schmidt, P. C. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(02)00011-8 · Cited by 211
Gryczke, A., Schminke, S., Maniruzzaman, M., Beck, J., & Douroumis, D. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.04.007 · Cited by 189
Singh, B., Dahiya, M., Saharan, V., & Ahuja, N. (2005) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v22.i3.10 · Cited by 162
Metadata
- Authors
- Bi, Y. X., Sunada, H., Yonezawa, Y., & Danjo, K.
- Affiliations
- Meijo University (JP)
- ORCID
- Bi, Y. X.
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 25
- Issue
- 5
- Pages
- 571-581
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2159269801
- Cited by
- 269
- References
- 8
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 16 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 23 · 2012: 19
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Engineering › Computational Mechanics › Granular flow and fluidized beds
- Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
- Keywords
- fast disintegrating tablets, direct compression, tablet porosity, tablet tensile strength, disintegration time, microcrystalline cellulose, erythritol, sweeteners, formulation optimization, response surface methodology
- MeSH terms
- Cellulose, Chemistry, Pharmaceutical, Tablets, Technology, Pharmaceutical, Tensile Strength
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